In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test

Zotov, Arsen K.; Gavdush, A. A.; Katyba, Gleb M.; Safonova, Larisa P.; Chernomyrdin, Nikita V.; Dolganova, Irina N.

doi:10.1117/1.jbo.26.4.043003

Cited by 9 publications

(4 citation statements)

References 60 publications

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“…Since THz waves are non-ionizing, they represent a suitable option for noninvasive spectroscopy, imaging [161,162] and insitu monitoring [163,164]. Since THz radiation is highly sensitive to polar molecules, it has been successfully used to determine the hydration levels in skin tissue [159], both in vitro and in-vivo [161,165], in order to discern between tumoral and healthy tissues for cancer diagnosis [166][167][168].…”

Section: Molecular Dynamics Structural Biology and Bio-medical Applic...mentioning

confidence: 99%

Multi-Pass Free Electron Laser Assisted Spectral and Imaging Applications in the Terahertz/Far-IR Range Using the Future Superconducting Electron Source BriXSinO

et al. 2022

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Free-Electron Lasers are a rapidly growing field for advanced science and applications, and worldwide facilities for intense field generation, characterization and usage are becoming increasingly popular due to their peculiarities, including extremely bright, coherent, wide band tunable ultra-short pulses which are not achievable with other techniques up to now. In this review we give a thorough survey of the latest advances in the Free-Electron Laser-based field generation and detection methodologies and then present the main characteristics of a future THz/IR source, named TerRa@BriXSinO, based on a superconducting linear accelerator. The foreseen source is strongly monochromatic, with a bandwidth of 1% or smaller, highly coherent both transversally and longitudinally, with extreme versatility and high frequency tunability. After introducing the most recent and novel FEL-assisted scientific investigations, including fundamental explorations into complex systems and time-dependent interactions and material dynamics, we present our vision on the potential use of the TerRa facility and analyze some possible applications, ranging from non-linear physics under extreme conditions to polarization sensitive imaging and metamaterial-based sensing.

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Section: Molecular Dynamics Structural Biology and Bio-medical Applic...mentioning

confidence: 99%

Multi-Pass Free Electron Laser Assisted Spectral and Imaging Applications in the Terahertz/Far-IR Range Using the Future Superconducting Electron Source BriXSinO

et al. 2022

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“…To solve the stated problem of monitoring the cryosurgical process, it is attractive to use optical sensors and methods, such as analysis of the opto-acoustic signal [ 28 , 29 , 30 ], terahertz monitoring [ 31 ], and diffuse reflectance analysis [ 32 , 33 ]. The latter can be implemented with optical fibers and, thus, be considered as a part of a cryosurgical instrument.…”

Section: Introductionmentioning

confidence: 99%

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

Zotov,

Pushkarev,

Alekseeva

et al. 2024

Sensors

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This work describes a sapphire cryo-applicator with the ability to sense tissue freezing depth during cryosurgery by illumination of tissue and analyzing diffuse optical signals in a steady-state regime. The applicator was manufactured by the crystal growth technique and has several spatially resolved internal channels for accommodating optical fibers. The method of reconstructing freezing depth proposed in this work requires one illumination and two detection channels. The analysis of the detected intensities yields the estimation of the time evolution of the effective attenuation coefficient, which is compared with the theoretically calculated values obtained for a number of combinations of tissue parameters. The experimental test of the proposed applicator and approach for freezing depth reconstruction was performed using gelatin-based tissue phantom and rat liver tissue in vivo. It revealed the ability to estimate depth up to 8 mm. The in vivo study confirmed the feasibility of the applicator to sense the freezing depth of living tissues despite the possible diversity of their optical parameters. The results justify the potential of the described design of a sapphire instrument for cryosurgery.

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“…Поэтому часто криохирургические манипуляции сопровождаются дополнительными методами мониторинга, а именно ультразвуковой диагностикой, магнитно-резонансной и компьютерной томографией, термометрией [12][13][14][15]. Наряду с этим показана перспективность методов оптического мониторинга [16][17][18], в частности применение акустооптических систем [16,17]. Однако указанные методы не позволяют решить задачу совмещения функции криоаппликатора и мониторинга в одном компактном инструменте.…”

Section: Introductionunclassified

Определение Эффективных Рассеивающих Свойств Среды В Процессе Криодеструкции С Помощью Сапфирового Криоаппликатора

Долганова¹,

Zotov²,

Safonova³

et al. 2023

Оптика И Спектроскопия

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The task of monitoring the condition of the tissue during its cryodestruction is extremely relevant for cryosurgery. Previously, the concept of a sapphire cryoprobe was proposed, which makes it possible to detect diffusely scattered light from a tissue during an ice ball formation. This probe combines the advantages of sapphire as a promising material for cryosurgery, as well as the possibility of assessing the depth of tissue freezing in the contact area. The use of several light source channels inside the applicator, spaced at different distances from the detector channel, makes it possible to analyze the scattering properties of the medium using the methods of diffusion theory. In this paper, we consider the influence of the position and number of analyzed source channels on the signals recorded by the detector channel and the determined effective scattering coefficient of a two-component medium consisting of an iceball and unfrozen tissue. Differences in the scattering coefficient obtained for various channel configurations are shown, as well as the advantages of analyzing a large number of channels to describe the effective properties of the medium with a complex iceball boundary.

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In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test

Cited by 9 publications

References 60 publications

Multi-Pass Free Electron Laser Assisted Spectral and Imaging Applications in the Terahertz/Far-IR Range Using the Future Superconducting Electron Source BriXSinO

Multi-Pass Free Electron Laser Assisted Spectral and Imaging Applications in the Terahertz/Far-IR Range Using the Future Superconducting Electron Source BriXSinO

Optical Sensing of Tissue Freezing Depth by Sapphire Cryo-Applicator and Steady-State Diffuse Reflectance Analysis

Определение Эффективных Рассеивающих Свойств Среды В Процессе Криодеструкции С Помощью Сапфирового Криоаппликатора

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