The chapter is on ICT skills training for the deaf to enhance employability prospects to improve social-economic development. Deaf employment is a global issue. ICT skills training might reduce the challenge. Little is known about ICT skills training for the deaf. The author interviewed 5 parents and 15 ICT skills training for the deaf graduates at the Open University of Tanzania. Data were collected using an interview guide with support from an experienced sign language interpreter. Findings indicated that ICT skills training increased participation in learning, employment, networking, and social inclusion. However, they faced challenges related to community perception, resources availability, affordability, connectivity, funding, and availability of ICT skills training opportunities that met their special learning needs. Based on the results, people with disabilities have to learn ICT skills that meet their unique special needs to reduce the negative effects of the impact of disruptive technologies and employability in the 4th Industrial Revolution.