In-utero and childhood chemical exposome in six European mother-child cohorts

Haug, Line Småstuen; Sakhi, Amrit Kaur; Cequier, Enrique; Casas, Maribel; Maitre, Léa; Basagaña, Xavier; Andrušaitytė, Sandra; Chalkiadaki, Georgia; Chatzi, Leda; Coen, Muireann; Bont, Jeroen de; Dėdelė, Audrius; Ferrand, Joane; González, Juan R.; Gützkow, Kristine B.; Keun, Hector C.; McEachan, Rosemary; Meltzer, Helle Margrete; Petravičienė, Inga; Robinson, Oliver; Saulnier, Pierre‐Jean; Slama, Rémy; Sunyer, Jordi; Urquiza, José; Vafeiadi, Marina; Wright, John; Vrijheid, Martine; Thomsen, Cathrine

doi:10.1016/j.envint.2018.09.056

Cited by 148 publications

(105 citation statements)

References 57 publications

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“…( 33 ) A ratio of 1:1 was assumed for serum and plasma, whereas 1:2 ratios were assumed for whole‐blood versus serum/plasma. ( 33 ) The limit of detection (LOD) was 0.02 μg/L for samples assessed at NIPH, whereas for samples assessed at RWTH Aachen University, LODs were 0.05 µg/L for PFNA and 0.1 µg/L for the other PFAS. We used all available PFAS measures and applied quantile regression imputation of left‐censored data (QRILC) to obtain singly imputed values for samples with concentration below LOD (ranging from 0.3% to 4.7% across PFAS).…”

Section: Participants and Methodsmentioning

confidence: 99%

Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children

et al. 2020

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Background and Aims Per‐ and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children. Approach and Results We used data from 1,105 mothers and their children (median age, 8.2 years; interquartile range, 6.6‐9.1) from the European Human Early‐Life Exposome cohort (consisting of six existing population‐based birth cohorts in France, Greece, Lithuania, Norway, Spain, and the United Kingdom). We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluorononanoate, perfluorohexane sulfonate, and perfluoroundecanoate in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gamma‐glutamyltransferase in child serum. Using Bayesian kernel machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confidence interval, 1.21‐1.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branched‐chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine [PC] aa C36:1 and Lyso‐PC a C18:1). Conclusions Developmental exposure to PFAS can contribute to pediatric liver injury.

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Section: Participants and Methodsmentioning

confidence: 99%

Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children

et al. 2020

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“…Approximately a third of the retained exposome studies had a prospective longitudinal design (n = 30, 37%), of which 26 were based on nine large population-based cohorts; the rest four longitudinal studies were relatively small in size, including between 6 and 378 subjects [46][47][48][49]. Out of the 26 studies, eleven were published as part of the Human Early-Life Exposome (HELIX) project using data from six European birth cohorts ( [50][51][52][53][54][55][56]), and among these studies, four belonged to the Spanish INMA (INfancia y Medio Ambiente) [57][58][59][60][61]. Four studies (of the 26) were published as part of the Avon Longitudinal Study of Parents and Children (ALSPAC), a 20-year population-based cohort designed to determine the influence of environmental (physical and psychological) and genetic factors on the health status and development of the offspring.…”

Section: Description Of the Selected Articlesmentioning

confidence: 99%

A Scoping Review on the Characteristics of Human Exposome Studies

2019

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Embraced as a breaking through methodological framework, the exposome is accompanied by novel exposure assessment methods and data processing tools or models. However, systematic mapping of the landscape of exposome studies, including their characteristics, components, tools and language has not been done so far. We conducted a scoping review to answer the question: "Which main domains of the human exposome have been included in the literature and which metrics of exposure(s)/ outcome(s) have been used?" We performed a comprehensive search of human studies containing the word "exposom*" and published up to March 8, 2019. We screened 1133 records and 82 studies were included in the analysis. Most studies took place in Europe. Data analysis showed the non-systematic use of the exposome term. Most studies had a longitudinal design (n = 30, 37%), were conducted on adults (n = 40, 51%), and had a clearly defined health outcome in methodology (n = 48, 61%). Omics tools, such as metabolomics were used in 38 studies (49%), while environment-wide association analysis was used in 9 studies (11%). Thirty-seven (48%) studies included all three exposome domains (general external, specific external and internal) while 33 (42%) studies included two. Despite the large number of environmental components that comprise each of the exposome domains, only a subset has been currently studied. An optimized consideration of the components from all exposome domains, as well as the standardization of the exposure and outcome assessment methods is warranted to advance the utility of the human exposome concept.

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“…OCs and PBDEs were adjusted for serum lipid concentrations, and phthalate metabolites, phenols, OP pesticide metabolites and cotinine were adjusted for urinary creatinine. Details on the laboratories, limits of quantification, limits of detection and quality control can be found in Haug et al (2018). Table A1.5 in the Annex shows the percent of quantifiable samples, which were higher than 90% for 77% of the childhood exposures and for 82% of the pregnancy exposures.…”

Section: Exposome Variablesmentioning

confidence: 99%

“…A2.2 for childhood). Further details on chemical exposure biomarkers are found in Haug et al (2018). In order to summarize these data, we computed a single principal component separately for each exposure group.…”

Section: Exposure Levelsmentioning

confidence: 99%

“…were also small for phenols and OP pesticides (between 0 and 0.20). The temporal changes for chemicals in HELIX have been reported by Haug et al (2018), with slight differences due to different imputation methods used. Diet variables showed low correlations (r < 0.1) with the exception of fish and cereal intake with somewhat greater values (r = 0.22 and 0.35 respectively).…”

Section: Correlations Between Pregnancy and Childhood Exposuresmentioning

confidence: 99%

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