In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species

Badham, Helen J.; Winn, Louise M.

doi:10.1016/j.taap.2010.01.002

Cited by 44 publications

(31 citation statements)

References 57 publications

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“…The commonly used cell line is the human promyelocytic leukaemia cell line HL-60, used in 19 out of 52 identified in vitro studies. Other human leukaemic cell lines include K562, MEG-01, TK6, CEM and Jurkat, and immortalised cell lines from other species such as CHO (Chinese hamster ovary) (Pandey et al, 2009;Winn, 2003), IAR6.1 and IAR20 (rat liver epithelial cells) (Rivedal & Leithe, 2008;Rivedal & Witz, 2005a, HD3 (chicken erythroblast) (Badham & Winn, 2010a;Wan & Winn, 2007), mouse hepatoma 1c1c7 (Badham & Winn, 2007) and myeloblastic 32D cells have been used in a few studies as well.…”

Section: Supporting Publications 2016: En-955 128mentioning

confidence: 99%

“…Then it is followed by oxidative stress as an early key event associated with benzene and its metabolites (Badham & Winn, 2010a;Goldman et al, 1999;Ishihama et al, 2008;Kolachana et al, 1993;Li & Trush, 1993;Nishikawa et al, 2012;Oikawa et al, 2001;Ruiz-Ramos et al, 2005;Wan & Winn, 2007;Wiemels & Smith, 1999;Zhang et al, 1993). The metabolites most involved in the benzeneinduced oxidative stress are HQ (Badham & Winn, 2010a;Ishihama et al, 2008;Kolachana et al, 1993;Li & Trush, 1993;Wiemels & Smith, 1999), 1,4-BQ (Ishihama et al, 2008; Ruiz-Ramos et al,…”

Section: Supporting Publications 2016: En-955 129mentioning

confidence: 99%

“…The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Winn, 2010aWinn, , 2010bLau et al, 2009). For inhalation studies, a range of 10-400 ppm has been used for subchronic/chronic exposure studies (i.e.…”

Section: Supporting Publications 2016: En-955 130mentioning

confidence: 99%

“…fluctuations of myeloid or erythroid colonies) is the most commonly reported downstream key event associated with benzene exposure (6 out of 24 studies) regardless of the exposure route Badham & Winn, 2010a, 2010bNiculescu & Kalf, 1995;Sun et al, 2015;Yoon et al, 2002). In particular, in utero exposure of benzene altered the foetal liver and erythroid colony numbers in the offspring, which might have increased susceptibility of developing haematopoietic as well as hepatic tumours later in life Badham & Winn, 2010a, 2010b. Genotoxicity (e.g.…”

Section: Supporting Publications 2016: En-955 130mentioning

confidence: 99%

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Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Choi¹,

Polcher²,

Joas³

2016

EFSA Supporting Publications

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This report presents the outcomes of a systematic review (SR) identifying the mechanisms and chemicals involved in the pathogenesis of Parkinson's disease (PD) and childhood leukaemia (CL). This work serves as a basis for defining and mapping the causal linkages between a molecular initiating event (MIE) and a final adverse outcome (AO) that are relevant for the development of a prototype adverse outcome pathway (AOP) for assessing risk factors for PD and CL. Search for literature from 1990 to present was conducted using Web of Science, PubMed and TOXNET, and relevant references were selected using established inclusion/exclusion criteria and ranked using a set of quality control factors.For PD, 7,384 individual references were identified to be relevant for PD pathogenesis and chemicals associated with PD. Dopaminergic neurodegeneration in the substantia nigra leading to locomotor deficits was identified as the AO in PD. Other identified key events in PD pathogenesis include mitochondrial dysfunction, cellular accumulation of alpha-synuclein and oxidative stress. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, rotenone and paraquat are some chemicals identified to be associated with PD pathogenesis.For CL, 1,988 individual references were identified to be relevant for CL pathogenesis and chemicals associated with CL. Chromosomal translocation, genetic damage/mutation and hyperdiploidy are considered as driving forces of CL. Except for infant leukaemia, CL pathogenesis requires a 'two-hit' model with an initiating event occurring in utero followed by a secondary hit potentially occurring after birth. Potential MIEs leading to these driving mechanisms include aberrant DNA topoisomerase II activity and erroneous DNA repair. Epigenetics appears to also play an influential role in CL pathogenesis. Benzene, bioflavonoids and organophosphates are some chemicals identified to be implicated in CL pathogenesis.The challenges of developing AOPs for these two diseases and the data gaps identified from the outcomes of this SR are also elaborated in this report. The present document has been produced and adopted by the bodies identified above as authors. This task has been carried out exclusively by the authors in the context of a contract between the European Food Safety Authority and the authors, awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. KEY WORDSSystematic Review, Parkinson Disease, Childhood Leukaemia, Pathogenesis, Chemicals, Pesticides, Adverse Outcome Pathway SUMMARYThe aim of this project was to perform a systematic review (SR) to collect relevant publications related to the mechanisms involved in the pathogenesis of Parkinson's disease (PD)...

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Section: Supporting Publications 2016: En-955 128mentioning

confidence: 99%

Section: Supporting Publications 2016: En-955 129mentioning

confidence: 99%

Section: Supporting Publications 2016: En-955 130mentioning

confidence: 99%

Section: Supporting Publications 2016: En-955 130mentioning

confidence: 99%

See 2 more Smart Citations

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Choi¹,

Polcher²,

Joas³

2016

EFSA Supporting Publications

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show abstract

“…Together with BZ, HQ is also achieved as a component of tobacco, and high concentrations are released during smoking . In addition, HQ is a relevant BZ endogenous metabolite and it has been clearly demonstrated that HQ is a key determinant for immune suppression and leukemias development in human exposed to BZ (Badham et al, 2010;Bi et al, 2010;Atkinson, 2009). These effects have been partially associated to DNA lesions, as HQ exposure causes oxidative DNA damage in a variety of cells, including circulating leukocytes and lung tissue (Melikian et al, 2008;Várkonyi et al, 2006;Leanderson, 1993).…”

Section: Introductionmentioning

confidence: 99%

Caracterização dos efeitos da exposição à hidroquinona sobre o recrutamento leucocitário para o pulmão inflamado

Ribeiro¹

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An Overview of the Effects of Organic Compounds on Women's Reproductive Health and Birth Outcomes

Reutman¹,

Meadows²

2013

Effects of Persistent and Bioactive Organic Pollutants on Human Health

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In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species

Cited by 44 publications

References 57 publications

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Caracterização dos efeitos da exposição à hidroquinona sobre o recrutamento leucocitário para o pulmão inflamado

An Overview of the Effects of Organic Compounds on Women's Reproductive Health and Birth Outcomes

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