In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Nadeau, Kari; Li, Zhigang; Farzan, Shohreh F.; Koestler, Devin C.; Robbins, David J.; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden T.; Enelow, Richard I.; Korrick, Susan A.; Karagas, Margaret R.

doi:10.1016/j.clim.2014.09.004

Cited by 78 publications

(51 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The European Food Safety Authority Panel 3 estimated that children younger than 3 years consume 2 to 3 times the amount of inorganic As from food than adults per kilograms of body weight. In addition to being more highly exposed to As, children appear to be far more sensitive to the potential carcinogenic effects of As 49,50 and have a heightened risk for adverse growth, adverse immune response, and adverse neurodevelopmental outcomes, 25,51–53 even at relatively low levels of exposure. 24,54 Our results indicate that consumption of rice and rice products increases infants’ exposure to As and that regulation could reduce As exposure during this critical phase of development.…”

Section: Discussionmentioning

confidence: 99%

Association of Rice and Rice-Product Consumption With Arsenic Exposure Early in Life

et al. 2016

Self Cite

View full text Add to dashboard Cite

IMPORTANCE Rice-a typical first food and major ingredient in various infant foods-contains inorganic arsenic (As), but the extent of As exposure from these foods has not been well characterized in early childhood.OBJECTIVE To determine the types and frequency of rice and rice-containing products consumed by infants in the first year of life and the association with As biomarker concentrations.DESIGN, SETTING, AND PARTICIPANTS Included were infants from singleton births of pregnant women enrolled in the New Hampshire Birth Cohort Study from 2011 to 2014 whose parents were interviewed during their first year of life. Enrolled women from selected clinics were aged 18 to 45 years, living in the same residence since their last menstrual period, in households served by a private water system, and had no plans to move during pregnancy. Data on infants' intake of rice and rice products were collected from interviews with their parents at 4, 8, and 12 months' follow-up and from a 3-day food diary at 12 months from March 2013 to August 2014.EXPOSURES Infants' intake of rice and rice products. MAIN OUTCOMES AND MEASURESTotal urinary As and the sum of As species measured using inductively coupled mass spectrometry and high-performance liquid chromatography with inductively coupled mass spectrometry. Commonly reported infant rice snacks were tested for As. RESULTSWe obtained dietary data on 759 of 951 infants (79.8% participation rate). Of these, 391 infants (51.7%) were male, and the mean (SD) gestational age was 39.4 (1.7) weeks. An estimated 80% were introduced to rice cereal during their first year. At 12 months, 32.6% of infants (42 of 129) were fed rice snacks. Among infants aged 12 months who did not eat fish or seafood, the geometric mean total urinary As concentrations were higher among those who ate infant rice cereal (9.53 μg/L) or rice snacks (4.97 μg/L) compared with those who did not eat rice or rice products (2.85 μg/L; all P < .01). Infant rice snacks contained between 36 and 568 ng/g of As and 5 to 201 ng/g of inorganic As. CONCLUSIONS AND RELEVANCEOur findings indicate that intake of rice cereal and other rice-containing foods, such as rice snacks, contribute to infants' As exposure and suggest that efforts should be made to reduce As exposure during this critical phase of development.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Rice and Rice-Product Consumption With Arsenic Exposure Early in Life

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Arsenic is known to cause suppression of the immune system in multiple systems (Ahmed et al, 2014; Biswas et al, 2008; Nadeau et al, 2014; Soto-Peña et al, 2006; Vahter et al, 2008). However, the mechanism of arsenic induced immunosuppression is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells

Lauer

Liu

et al. 2016

Toxicology Letters

View full text Add to dashboard Cite

Environmental arsenic exposure is a public health issue. Immunotoxicity induced by arsenic has been reported in humans and animal models. The purpose of this study was to evaluate mechanisms of As+3 and MMA+3 toxicity in mouse thymus cells. Because we know that MMA+3 inhibits IL-7 signaling in mouse bone marrow pre-B cells, we studied the influence of As+3 and MMA+3 on T cell development in the thymus at the earliest stage of T cell development (CD4− CD8−, double negative, DN) which requires IL-7 dependent signaling. We found in a DN thymus cell line (D1) that a low concentration of MMA+3 (50 nM) suppressed IL-7 dependent JAK1, 3 and STAT5 signaling. As+3 suppressed STAT5 and Jak3 activations at higher concentrations (500 nM). Cell surface expression of the IL-7 receptor (CD127) was also suppressed by 50 nM MMA+3, but was increased by 500 nM As+3, indicating possible differences in the mechanisms of action of these agents. A decrease in cyclin D1 protein expression was observed in D1 cells exposed to As+3 at 500 nM and MMA+3 starting at 50 nM, suggesting that arsenic at these environmentally-relevant doses suppresses early T cell development through the inhibition of IL-7 signaling pathway.

show abstract

“…Arsenic induced immunotoxicity has been studied by many groups both in vitro and in vivo (Ahmed et al, 2014; Nadeau et al, 2014; Biswas et al, 2008; Vahter et al, 2008; Soto-Peña et al, 2006; Gonsebatt et al, 1994). However, only a few studies have addressed the toxicity of As exposure to immune cells at environmentally relevant concentrations.…”

Section: Introductionmentioning

confidence: 99%

Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite

McClain

Medina

et al. 2016

Toxicology Letters

View full text Add to dashboard Cite

It is known in humans and mouse models, that drinking water exposures to arsenite (As+3) leads to immunotoxicity. Previously, our group showed that certain types of immune cells are extremely sensitive to arsenic induced genotoxicity. In order to see if cells from different immune organs have differential sensitivities to As+3, and if the sensitivities correlate with the intracellular concentrations of arsenic species, male C57BL/6J mice were dosed with 0, 100 and 500 ppb As+3 via drinking water for 30 d. Oxidation State Specific Hydride Generation-Cryotrapping- Inductively Coupled Plasma- Mass Spectrometry (HG- CT- ICP- MS) was applied to analyze the intracellular arsenic species and concentrations in bone marrow, spleen and thymus cells isolated from the exposed mice. A dose-dependent increase in intracellular monomethylarsonous acid (MMA+3) was observed in both bone marrow and thymus cells, but not spleen cells. The total arsenic and MMA+3 levels were correlated with an increase in DNA damage in bone marrow and thymus cells. An in vitro treatment of 5, 50 and 500 nM As+3 and MMA+3 revealed that bone marrow cells are most sensitive to As+3 treatment, and MMA+3 is more genotoxic than As+3. These results suggest that the differential sensitivities of the three immune organs to As+3 exposure are due to the different intracellular arsenic species and concentrations, and that MMA+3 may play a critical role in immunotoxicity.

show abstract

In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Cited by 78 publications

References 71 publications

Association of Rice and Rice-Product Consumption With Arsenic Exposure Early in Life

Association of Rice and Rice-Product Consumption With Arsenic Exposure Early in Life

Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells

Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite

Contact Info

Product

Resources

About