In utero exposure to gestational diabetes and adiposity: does breastfeeding make a difference?

Hui, Lucas Chi Kwong; Li, A M; Nelson, E. A. S.; Leung, Gabriel M.; Lee, So Lun; Schooling, CM

doi:10.1038/s41366-018-0077-2

Cited by 10 publications

(6 citation statements)

References 43 publications

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“…In this environment-wide and epigenome-wide association study, we systematically examined associations of over four hundred exposures with adiposity in a unique Chinese birth cohort, as well as the association of DNA methylation with adiposity. Building on the previous studies in this birth cohort (19)(20)(21)23), we not only confirmed established risk factors, such as maternal second-hand smoking (48), but also added by identifying novel exposures not reported in previous EWAS in western settings (8,9), such as consumption of ASB and soymilk. The comparison with RCTs or MR studies support a role of higher birth weight, dairy intake, binge eating and possibly earlier puberty in adiposity.…”

Section: Discussionsupporting

confidence: 66%

“…For example, in the "Children of 1997" birth cohort, a large cohort in Hong Kong, the associations of sugar-sweetened beverages (19), breastfeeding (20), milk consumption frequency (21), sleep duration (22) and parental smoking (23) with childhood and adolescent adiposity have been examined, with some important differences detected. The associations for breastfeeding in Hong Kong are much more similar to those seen in randomized controlled trials (RCTs) than those typically seen in western settings (20). To take advantage of this unique setting, we conducted an environment-wide and epigenome-wide association study, to identify further potential drivers of adiposity.…”

Section: Introductionmentioning

confidence: 99%

“…As such, a study in young Chinese people in Hong Kong, a different setting provides “a sentinel for populations currently experiencing very rapid economic development” (17), may help identify whether these associations reflect SEP within a specific context or are biologically based as well as having the potential to identify any attributes relevant to the majority of the global population but not necessarily evident in more commonly studied Western populations, such as maternal birthplace (18). For example, in the “Children of 1997” birth cohort, a large cohort in Hong Kong, the associations of sugar-sweetened beverages (19), breastfeeding (20), milk consumption frequency (21), sleep duration (22) and parental smoking (23) with childhood and adolescent adiposity have been examined, with some important differences detected. The associations for breastfeeding in Hong Kong are much more similar to those seen in randomized controlled trials (RCTs) than those typically seen in western settings (20).…”

Section: Introductionmentioning

confidence: 99%

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Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Zhao

Fan

Huang

et al. 2022

Preprint

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Background: Increasing childhood adiposity is a global issue requiring potentially local solutions to ensure it does not continue into adulthood. We systematically identified potentially modifiable targets of adiposity at the onset and end of puberty in Hong Kong the most economically developed major Chinese city. Methods:We conducted an environment-wide association study (EWAS) and an epigenome-wide association study of adiposity to systematically assess associations with body mass index (BMI) and waist-hip ratio (WHR) in Hong Kong's population-representative "Children of 1997" birth cohort.Univariable linear regression was used to select exposures related to adiposity at ~11.5 years (BMI n≤7,119, WHR n=5,691) and ~17.6 years (n = 3,618) at Bonferroni-corrected significance, and multivariable linear regression to adjust for potential confounders followed by replication (n=308) and CpG by CpG analysis (n=286) at ~23 years. Findings were compared with evidence from randomized controlled trials (RCTs) and Mendelian randomization (MR) studies.Results: At ~11.5 and ~17.6 years the EWAS identified 14 and 37 exposures associated with BMI, as well as seven and 12 associated with WHR respectively. Most exposures had directionally consistent associations at ~23 years. Maternal second-hand smoking, maternal weight, and birth weight were consistently associated with adiposity. Diet (including dairy intake and artificially sweetened beverages), physical activity, snoring, binge eating, and earlier puberty were positively associated with BMI at ~17.6 years, while eating before sleep was inversely associated with BMI at ~17.6 years. Findings for birth weight, dairy intake, binge eating, and possibly earlier puberty are consistent with available evidence from RCTs or MR studies We found 21 CpGs related to BMI and 18 to WHR. Conclusions:These novel insights into potentially modifiable factors associated with adiposity at the outset and the end of puberty could, if causal, inform future interventions to improve population health in Hong Kong and similar Chinese settings..

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Zhao

Fan

Huang

et al. 2022

Preprint

Self Cite

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“…Two studies were eligible for inclusion (Hui et al, 2018; Martens et al, 2016). The details for both studies are included in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…BMI: One study reported on BMI z-score. Hui et al, in a prospective birth cohort, reported that breastfeeding does not attenuate the association between GDM exposure in utero and BMI in the offspring at 3 months of age (Table 1; Hui et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Protective Influence of Breastfeeding on Cardiovascular Risk Factors in Women With Previous Gestational Diabetes Mellitus and Their Children: A Systematic Review and Meta-Analysis

et al. 2021

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Background: There is evidence that breastfeeding may provide protection against cardiovascular risk factors in mothers with a history of gestational diabetes mellitus and their children who were exposed in utero. Research Aim: To perform a systematic review and meta-analysis of observational studies to ascertain the effects of breastfeeding on cardiovascular risk factors in women with previous gestational diabetes mellitus and their children exposed in utero. Methods: Studies assessing conventional cardiovascular risk factors in women with previous gestational diabetes mellitus and children exposed in utero stratified by breastfeeding/no breastfeeding or breastfed/not breastfed were included. Gestational diabetes mellitus was defined based on the International Association of Diabetes in Pregnancy Study Group definition or previous accepted definitions. Breastfeeding was defined as reported in each study. Results: The literature search yielded 260 titles, of which 17 studies were selected to be in the review. Women with previous gestational diabetes mellitus who did not breastfeed had higher blood glucose ( SMD: 0.32, 95% CI [0.12, 0.53]) and a greater risk of developing Type 2 diabetes mellitus ( RR: 2.08 95% CI [1.44, 3.00]) compared to women with no history. There were not enough studies to conduct a meta-analysis on the effects of breastfeeding on risk factors for cardiovascular disease among children exposed to gestational diabetes mellitus in utero. Conclusion: Breastfeeding appears to be protective against cardiovascular risk factors among women who experience gestational diabetes mellitus.

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Diabetes in Pregnancy and Breastfeeding

Armeni

Lambrinoudaki

2022

Comprehensive Clinical Approach to Diabetes During Pregnancy

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In utero exposure to gestational diabetes and adiposity: does breastfeeding make a difference?

Abstract: In utero GDM exposure was associated with greater adiposity during childhood and adolescence. Breastfeeding in early infancy from mothers with GDM was not associated with greater adiposity in children and thus should still be encouraged.

Cited by 10 publications

References 43 publications

Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Protective Influence of Breastfeeding on Cardiovascular Risk Factors in Women With Previous Gestational Diabetes Mellitus and Their Children: A Systematic Review and Meta-Analysis

Diabetes in Pregnancy and Breastfeeding

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