In vitro activation of human monocytes by silicones

Naim, John O.; Oss, Carel J. van; Ippolito, K. M. L.; Zhang, J.-W; Jin, Linhua; Fortuna, R; Buehner, Norene

doi:10.1016/s0927-7765(98)00023-x

Cited by 28 publications

(40 citation statements)

References 18 publications

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“…Silicone oil, silicone gel, and pristane all appear to prime these cells to overproduce IL-6 and IL-1␤ in response to LPS. This result is consistent with previous observations that silicones preabsorbed with protein activate monocytes in vitro (13). We ascribed this activation to the very hydrophobic nature of silicones, since polystyrene, preadsorbed with protein, also can activate monocytes in vitro (13).…”

Section: Discussionsupporting

confidence: 82%

“…Because low-MW silicone oils are poor adjuvants, we had assumed that only ruptured silicone gel-filled implants may pose a health risk. More recently, however, we demonstrated that both silicone gel and silicone oil (1,000 cs) can activate monocytes in vitro to overproduce proinflammatory cytokines (IL-6, IL-1␤, and TNF-␣) (13). Thus, our revised working hypothesis is that both silicone gels and silicone oils incite a chronic inflammation both locally and systemically.…”

Section: Discussionmentioning

confidence: 97%

“…Since we had previously observed that silicones activate monocytes/macrophages in vitro (13), this experiment afforded us an opportunity to study the effects of silicone on macrophages in vivo. The production of IL-6 and IL-1␤ by pooled peritoneal macrophages from mice treated with silicone oil, silicone gel, pristane, or PBS are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Silicone gel when mixed with bovine type II collagen is arithritogenic in female DA rats (11). Silicone elastomer, preadsorbed with plasma proteins, activates human monocytes/macrophages in vitro to secrete interleukin-1␤ (IL-1␤), IL-6, and tumor necrosis factor alpha (TNF-␣) (13). Also, recent work by McDonald et al has demonstrated that silicone gel enhances the development of autoimmune disease in NZB mice and has little effect on BALB/c mice (8).…”

mentioning

confidence: 99%

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Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Naim¹,

Satoh

Buehner³

et al. 2000

Clin Diagn Lab Immunol

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Although most published epidemiological studies have found little evidence of systemic autoimmune disease associated with silicone breast implants, there still remains a question of whether silicones can cause local and/or systemic immune dysfunction. This study further investigates the effects of silicones on autoantibody and immunoglobulin production and macrophage activation in female A.SW mice. Sixty mice were divided among four treatment groups receiving a 0.5-ml intraperitoneal injection of either phosphate-buffered saline (PBS), pristane, silicone gel, or silicone oil. Test bleeds were taken periodically for 6 months. In contrast to pristane, neither silicone gel nor silicone oil induced lupus-associated antinuclear autoantibodies (immunoglobulin G [IgG] anti-nRNP/Sm, Su, and ribosomal P) or lupus nephritis. However, serum IgM became elevated persistently within 1 month of silicone gel or silicone oil administration. Also, the level of IgG3 was clearly elevated in silicone oil-treated mice. In contrast, IgG1, IgG2a, and IgG2b levels were not affected greatly by either silicone gel or oil. Furthermore, peritoneal macrophages from silicone-and pristane-treated mice produced higher levels of interleukin-1␤ (IL-1␤) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation. These results suggest that silicone gels and oils are capable of inducing hypergammaglobulinemia and activating macrophages in female A.SW mice.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Naim¹,

Satoh

Buehner³

et al. 2000

Clin Diagn Lab Immunol

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“…Известно, что накопление и длительное активное функционирование макрофа-гов и лимфоцитов в тканях приводит к развитию хронического воспаления [9]. Выявлено, что при контакте с поверхностью капель жидкого силикона моноциты/макрофаги экспрессируют в 2 раза боль-ше провоспалительных цитокинов, таких как интерлейкин-1β, интерлейкин-6 и фактор некроза опухоли, в сравнении с силиконовыми эластомера-ми, из-за значительной площади поверхности ка-пель силиконового масла [10]. Как известно, сили-кон является синтетическим недеградируемым по-лимером, поэтому реакция макрофагов оканчивает-ся незавершенным фагоцитозом [8].…”

Section: рис 3 пациентка мunclassified

Clinical and morphological changes in the skin after lip contour correction using injections of silicone and hyaluronic acid

Гурьянов¹,

Соловьева²,

Муслимов³

et al. 2015

Klin. dermatol. venerol.

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Biocompatibility of poly(ether)urethane‐gold nanocomposites

Hsu

Tang

Tseng

2006

J Biomedical Materials Res

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We have prepared the nanocomposites of a polyether-type waterborne polyurethane (PU) incorporated with different amounts (17.4-174 ppm) of gold (Au) nanoparticles ( approximately 5 nm). The nanocomposite containing a certain amount (43.5 ppm) of gold was previously demonstrated to possess the optimal thermal and mechanical properties, as well as much reduced foreign body reactions in subcutaneous rats. In this study, the surface morphology, biocompatibility, oxidative degradation, and free radical scavenging ability of the nanocomposites were characterized in vitro. The nanocomposite at 43.5 ppm of gold ("PU-Au 43.5 ppm") exhibited different surface morphology confirmed by the atomic force microscope. PU-Au 43.5 ppm also showed enhanced cellular proliferation, reduced platelet and monocyte activation, and much less bacterial adhesion, relative to PU alone or nanocomposites at the other Au contents, in general. This better biocompatibility was associated with the surface morphological change in the presence of Au. The oxidative degradation in PU-Au 43.5 ppm was also inhibited. The increased oxidative stability corresponded to the greater free radical scavenging ability of the nanocomposites.

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In vitro activation of human monocytes by silicones

Cited by 28 publications

References 18 publications

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Clinical and morphological changes in the skin after lip contour correction using injections of silicone and hyaluronic acid

Biocompatibility of poly(ether)urethane‐gold nanocomposites

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