In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum

Ndjonka, Dieudonné; Bergmann, Bärbel; Agyare, Christian; Zimbres, Flávia M.; Lüersen, Kai; Hensel, Andreas; Wrenger, Carsten; Liebau, Eva

doi:10.1007/s00436-012-2905-y

Cited by 36 publications

(20 citation statements)

References 27 publications

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“…Moderate antiplasmodial activity of gallic acid was reported [ 33 ], and authors concluded that the activity was linked to its very strong antioxidant capacity [ 33 ]. In our study, β-sitosterol-3- O -β- d -glucopyranoside showed no activity, contrary to the reports of other authors who claimed appreciable potency for the same compound isolated from the bark of Dacryodes edulis (Burseraceae) [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

et al. 2015

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The aim of this work was to screen extracts from Annona muricata and Annona reticulata in vitro against Plasmodium falciparum. Crude ethanolic extracts, methylene chloride fractions, aqueous fractions, subfractions and isolated compounds (stigmasterol-3-O-β-d-glucopyranoside, lichexanthone, gallic acid and β-sitosterol-3-O-β-d-glucopyranoside) were tested for cytotoxicity on erythrocytes and Human Foreskin Fibroblasts cells and against the W2 strain of P. falciparum in culture. Results indicated that none of the extracts was cytotoxic at concentrations up to 10 µg/mL. Most of the extracts, fractions and subfractions inhibited the growth of P. falciparum with IC50 values ranging from 0.07 to 3.46 µg/mL. The most potent was the subfraction 30 from A. muricata stem bark (IC50 = 0.07 µg/mL) with a selectivity index of ˃ 142. Subfraction 3 from A. muricata root also exhibited very good activity (IC50 = 0.09 µg/mL) with a high selectivity index (SI ˃ 111). Amongst the isolated compounds, only gallic acid showed activity with IC50 of 3.32 µg/mL and SI > 10. These results support traditional claims for A. muricata and A. reticulata in the treatment of malaria. Given their limited cytotoxicity profile, their extracts qualify as promising starting points for antimalarial drug discovery.

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Section: Resultsmentioning

confidence: 99%

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

et al. 2015

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“…Ellagitannins (232–270) are the largest group of hydrolyzable tannins. Corilagin and geraniin are most extensively obtained from this genus and are characteristic compounds of ellagitannins, which exhibited multiple activities such as antioxidant, anti-HIV, antitumor, and antihyperalgesic activities [ 6 , 111 , 188 , 195 , 196 , 199 , 201 , 202 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…P. amarus presented protection effect on human RBCs damage caused by the virus [ 322 ]. The SI of P. muellerianus was higher than 5.3 for L-6 and MRC-5 cell lines [ 25 , 202 ].…”

Section: Biological Activitymentioning

confidence: 99%

The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review

Mao

Guo

et al. 2016

Evidence-Based Complementary and Alternative Medicine

109

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The plants of the genus Phyllanthus (Euphorbiaceae) have been used as traditional medicinal materials for a long time in China, India, Brazil, and the Southeast Asian countries. They can be used for the treatment of digestive disease, jaundice, and renal calculus. This review discusses the ethnopharmacological, phytochemical, and pharmacological studies of Phyllanthus over the past few decades. More than 510 compounds have been isolated, the majority of which are lignins, triterpenoids, flavonoids, and tannins. The researches of their remarkable antiviral, antioxidant, antidiabetic, and anticancer activities have become hot topics. More pharmacological screenings and phytochemical investigations are required to support the traditional uses and develop leading compounds.

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“…43 Ellagic acid (1) is considered an important bioactive compound in plants presenting antimalarial activity. 44,45 However, there is a controversy about the activity of this molecule in different in vitro antimalarial studies. Reddy et al 46 did not observe any activity for ellagic acid in a p-LDH assay against Plasmodium falciparum (D6 and W2).…”

mentioning

confidence: 99%

Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

Souza¹,

Nascimento²,

Borsodi³

et al. 2017

J. Braz. Chem. Soc.

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Poincianella pluviosa is a tree whose stem bark is reputed to have antidiarrheal, wound healing, antitumoral and antimalarial properties. Considering that the leaves of the tree are a more abundant and renewable source than the stem bark, we chose to study the antimalarial potential of this organ part. The aqueous leaf extract exhibited a rich phenolic profile. It was active (IC 50 = 6.88 ± 1.64 µg mL -1 ) against chloroquine resistant Plasmodium falciparum (W2) without toxicity to HepG2 A16 cells. The organic fraction was more active (IC 50 = 1.83 µg mL -1 ) than the aqueous leaf extract itself. Ten phenolic compounds were obtained from the latter. This is the first report on the phenolic composition of P. pluviosa leaves. Ellagic acid (IC 50 = 0.215 ± 0.007 µg mL -1 ) proved to be 32 fold more active than the aqueous leaf extract itself. Considering their renewable aspect, leaves of P. pluviosa appear to be a more interesting source of antimalarial compounds than stem bark.Keywords: Poincianella pluviosa var. peltophoroides, leaves, ellagic acid, malaria, Plasmodium falciparum (W2) IntroductionA reduction in the incidence of tropical diseases such as malaria in poor countries is considered a major goal of the international community.1,2 In 2013, malaria was reported to be a threat to 198 million people causing 584,000 deaths in the world, mostly children under 5 years old in Africa. The impact of this disease is a major risk with the growth of world's population, mainly in regions without access to health services. The lack of sufficient financial resources and public health capacities in poor endemic countries led to the use of inefficient medicines and/or protocols resulting in an increase of mortality rate and spread of parasite resistance. 2,3 Malaria is an infectious disease caused by protozoa of the genus Plasmodium, which is transmitted by female Anopheles sp. mosquitoes. Five species of Plasmodium are able to infect humans, Plasmodium falciparum being considered the most dangerous. 4 Some clinical manifestations such as fever, chills, mild anemia and diarrheas are associated with malaria. 3,5 According to World Health Organization (WHO)-established protocols, 2 the treatment of uncomplicated Plasmodium falciparum malaria involves artemisininbased combination therapy with drugs such as mefloquine, piperaquine or the sulfadoxine/pyrimethamine combination. Nowadays, antimalarial therapy in endemic regions is more difficult to manage since the parasite has become resistant to most antimalarial drugs. 3,6 The resistance to artemisinin emerged in regions where this drug was used in a monotherapy protocol. 2,7 This situation continuously stimulates the search for new antimalarial drugs, especially from natural sources. 1de Souza et al. 1319 Vol. 29, No. 6, 2018 Plants showing proven antimalarial activity still represent a promising source of new medicines. It is important to note that some antimalarial drugs such as artemisinin and quinine have plant origin. 1,6,8 Poincianella pluviosa (DC.) L. P. Queiroz ...

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In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum

Cited by 36 publications

References 27 publications

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review

Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

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