In vitro activity of levamisole on the infective larvae, microfilariae and adult worms of Breinlia sergenti

Natarajan, P; Zaman, V.; Yeoh, T. S.

doi:10.1016/0020-7519(74)90107-6

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…Levamisole appears to have a paralysing action on adult worms and probably acts as a neuromuscular blocking agent like its dextro-isomcr, tctramisolc (Gaitoude 1971). The sustained contracture of the somatic muscles of S. cervi results in the irreversible paralysis of the worm-a condition similarly reported in another filarial worm, Breinlia sergenti and Ascaris following in vitro treatmen t with levamisole (Natarajan et al 1974;Van den Bosschc 1972).…”

Section: Disclissiodmentioning

confidence: 63%

Histochemical changes inSetaria cervi caused by certain anthelmintics

Baqui

1982

Proc Ani Sci

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The present study deals with the preliminary ill vivo screening of suramin and Ievamisole 1Il rei-Setaria cervi system with special reference to the histochemical changes in the adult worms caused by the drugs. Levamisole proved to be highly effective as a micro-and macro-filaricidal agent. It also appears to be interfering with the normal activity of alkaline phosphatase and' glycogen of the adult worms with no apparent effect on its protein content. The drug also causes irreversible paralysis in adult worms. Suramin, though an active pharmacological agent, proved to be completely ineffective 011 microfilariae as wcll as on adult worms of Setaria cervi. Consequently, no notable alterations in the histochemistry of the parasite following suramin treatment were observed.

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