In vitro activity of selected natural products against Eimeria tenella sporozoites using reproduction inhibition assay

Green Synthesis of ZnO/CuO Nanocomposites Using Parsley Extract for Potential In Vitro Anticoccidial Application

“…At the highest concentration of 1 mg/mL, after 5 days, 15.9 ± 0.1% of the oocysts were damaged, while only 38.6 ± 0.17% of them were sporulated. The results in this study are supported by the most recent work by Thabet, Alzuheir, Alnassan, Daugschies, and Bangoura as a preliminary to in vivo investigations that will aid in the development of new anticoccidial candidates; RIA was found suitable to evaluate the anticoccidial activity displayed by the tested natural compounds. Also, the potent anticoccidial activities of zinc oxide nanoparticles have been studied previously. , Furthermore, ultrastructural damage to the oocysts was seen at concentrations of 0.5 and 0.1 mg/mL.…”

Review on the Diverse Biological Effects of Glabridin

“…Glabridin has been screened to inhibit the replication of E. tenella by 75%, 50%, and 30% at the doses of 21.43 μg/mL, 5.28μg/mL, and 0.96μg/mL, respectively. At the dose of 21.43 μg/mL, glabridin significantly augments the expression of stress-induced factors NADPH and EtPP5 in E. tenella sporozoites 86 ( Table 1 ).…”

“… [ 84 ] E. tenella Inhibits the replication of by 75%, 50%, and 30% at the doses of 21.43 μg/mL, 5.28μg/mL, and 0.96μg/mL, respectively. [ 86 ] Bone protection RAW264.7 cells were exposed to 1, 2, and 5 μM glabridin Increases the activity of TRAF6, GAB2, ERK2, JNK1, and MKK7, enhances the expression of c-FOS and NFATc1, and elevates the productions of MMP-9, cathepsin K, CAII, TCIRG1, OSTM1, and CLCN7. [ 87 ] C2C12 cells were exposed to 10 μM glabridin Abolishes dexamethasone-stimulated protein degradation [ 88 ] L6 myotubes were exposed to 3, 10, and 30 μM glabridin Stimulates AMPK-dependent GLUT4 translocation [ 89 ] MC3T3-E1 cells were exposed to 0.01, 0.1, and 1 μM glabridin Inhibits MG-induced cytotoxicity and cell death [ 90 ] MC3T3-E1 cells were exposed to 5 μM glabridin Ameliorates dRib-induced oxidative damage and increases ALP, OPN, OPG, OC, and BMPs expression by up regulating the expression of PI3K/AKT2 signaling pathway [ 91 ] MSCs were exposed to 1, 10, and 50 μM glabridin Increases the expression of Oct4, Dlx5, Runx5, Osteocalcin, and Osteopontin [ 96 ] Cardiovascular protection Male New Zealand Rabbits receive 2 mg/kg glabridin by oral catheter for 6 weeks Down regulation of MLCK/phosphorylated MLC system through MAPK signaling [ 21 ] ECV-304 cells were exposed to 30 and 3000 nM glabridin Increases DNA synthesis, exhibits a bi-phasic effect on the proliferation of VSMC [ 100 ] Colonic macrophages from DOX-treated male C57BL/6 mice were exposed to 15 and 30 μM glabridin Prevents against DOX-induced dysbiosis by modulating LPS/NF-κB and butyrate-STAT6 signaling …”