In Vitro Activity of the Essential Oil of <i>Cinnamomum zeylanicum</i> and Eugenol in Peroxynitrite-Induced Oxidative Processes

Chericoni, Silvio; Prieto, José M.; Iacopini, P.; Cioni, P. L.; Morelli, Ivano

doi:10.1021/jf050183e

Cited by 107 publications

(64 citation statements)

References 31 publications

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“…CAR has shown anti-tumorigenic activity in hepatocellular carcinoma, both in vitro and in vi o [33,34]. Additional anti-in ammatory and antitumor activities of CAR have been reported [16,[18][19][20][21]. Jayakumar et al [33] showed that CAR pretreatment had protective e ect against diethylnitrosamine-induced hepatocellular carcinoma in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have indicated that CAR exhibits antiin ammatory [15], anti-microbial [16] and anti-viral activities [17]. Anti-carcinogenic and anti-tumorigenic activity [16,18], and antioxidant properties [19][20][21] have also been attributed to CAR. A recent study conducted in rats demonstrated that CAR was not hepatotoxic at the applied dosage and, in fact, protected against ischemia/reperfusion-associated damage to the liver [22].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Bozkurt¹,

Em²,

Oktayoğlu³

et al. 2014

CIM

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TurkeyCarvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats AbstractPurpose: e purpose of this study was to investigate the e ect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats.Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the rst day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens.Results: MDA, TOS and OSI levels were signi cantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was signi cantly reduced in the MTX group compared with the control group. e administration of CAR was associated with signi cantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the di erence in histological scores did not meet the threshold of statistical signi cance. e folic acid antagonist methotrexate (MTX) is used clinically to inhibit the synthesis of purines and pyrimidines [1]. MTX is commonly used at high doses to limit the growth of malignancies, but may also be used at low doses in in ammatory diseases, including psoriasis and rheumatoid arthritis, to inhibit the proliferation of in ammatory leukocytes [2][3][4]. MTX remains an essential component of modern clinical therapy for acute lymphoblastic leukemia and is the primary treatment for malignant gestational trophoblastic disease [5]. In addition to anti-proliferative activity, MTX has antiin ammatory and immunomodulatory properties; however, cytotoxic e ects and other side e ects limit the e cacy of MTX as an anti-in ammatory. Signi cant side e ects of MTX have been described in several organ systems. In particular, MTX has a detrimental e ect on kidney function [6]; however, the mechanism of MTX-induced toxicity remains unclear. More than 90% of MTX is ltered by the kidneys [7] and MTX treatment is known to cause renal failure at high doses [8]. Renal impairment can result in altered metabolism of MTX, delayed drug excretion and, subsequently, systemic toxicity. e toxic e ects of MTX are typically treated through hydration and alkalinization of the patient; however, these methods are insu cient to prevent all instances of MTX toxicity. Reactive oxygen species (ROS) have been implicated in the pathogenesis of MTX-induced renal damage [9,10]. MTX produces free oxygen radicals, resulting in enhanced li...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Bozkurt¹,

Em²,

Oktayoğlu³

et al. 2014

CIM

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“…Eugenol Main component of clove -Syzygium aromaticum (Jirovetz et al 2006) and cinnamon -Cinnamomum zeylanicum oils (Chericoni et al 2005). Used as a flavor, in dentistry as a local anesthetic, in the manufacture of vanillin and clandestine production of phenyllamines (Hunter 2009), and in perfumery for oriental and spicy notes (Bauer and Garbe 2001).…”

Section: Phenylpropanoidsmentioning

confidence: 99%

Essential Oils Chemistry

Zuzarte

Salgueiro

2015

Bioactive Essential Oils and Cancer

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“…It has traditionally been used to treat toothache, fight bad breath and treatment common cold [6][7][8][9] . The bark of tree consists of volatile oil, possesses many medicinal properties like antibacterial, anti-oxidant, anti-ulcer, antidiabetic [10][11][12] and antifungal (Bruneton et al, 1998). Cinnamaldehye is the most prevalent with concentration of 6,000 -30,000 ppm 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antifungal and Antibacterial Activity and Analysis of Bioactive Phytochemical Compounds of Cinnamomum Zeylanicum (Cinnamon Bark) using Gas Chromatography-Mass Spectrometry

Hameed¹,

Al-Tameme²,

Mohammed³

2016

Orient. J. Chem

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Phytochemicals are chemical compounds often referred to as secondary metabolites. Thirty nine bioactive phytochemical compounds were identified in the methanolic extract of Cinnamon bark. The identification of phytochemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC-MS analysis of Cinnamomum zeylanicum revealed the existence of the 6 -Oxa-bicyclo[3

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In Vitro Activity of the Essential Oil of Cinnamomum zeylanicum and Eugenol in Peroxynitrite-Induced Oxidative Processes

Cited by 107 publications

References 31 publications

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats

Essential Oils Chemistry

Evaluation of Antifungal and Antibacterial Activity and Analysis of Bioactive Phytochemical Compounds of Cinnamomum Zeylanicum (Cinnamon Bark) using Gas Chromatography-Mass Spectrometry

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