In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus

Yu, Xinguang; Song, Xingguo; Cai, Yun; Liang, Beibei; Lin, Ding; Wang, Rui

doi:10.1038/ja.2010.105

Cited by 19 publications

(13 citation statements)

References 24 publications

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“…Finally, fosfomycin was bacteriostatic against vancomycin-resistant enterococci (VRE) in urinary stents biofilms. The MIC 90 of VRE strains increased from 64 mg/liter in planktonic cultures to 128 mg/liter in biofilm cultures (36).…”

Section: Activity In Biofilmsmentioning

confidence: 99%

“…Table 2 shows the susceptibility of contemporary bacteria to fosfomycin from the larger studies published from 2010 onwards (36,56,57,61,. Regarding Gram-positive bacteria, contemporary studies showed that fosfomycin is active against the majority of S. aureus strains (Ͼ90%), including MRSA, as well as coagulase-negative staphylococci (CoNS) (36,56,61,72,75,82,83,87,88,90). However, one study reported that only 33.2% of MRSA strains were susceptible to fosfomycin (90).…”

Section: Susceptibility Reports (Gram-negative and Gram-positive Isolmentioning

confidence: 99%

“…Regarding Gram-positive bacteria, contemporary studies showed that fosfomycin is active against the majority of S. aureus strains (Ͼ90%), including MRSA, as well as coagulase-negative staphylococci (CoNS) (36,56,61,72,75,82,83,87,88,90). However, one study reported that only 33.2% of MRSA strains were susceptible to fosfomycin (90). Similarly, fosfomycin activity against enterococci, including VRE strains, varied in the available studies, with some of the studies reporting activity as low as 30% (36,91,92).…”

Section: Susceptibility Reports (Gram-negative and Gram-positive Isolmentioning

confidence: 99%

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Fosfomycin

et al. 2016

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SUMMARYThe treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new antibiotics active against such MDR and XDR bacteria. As a result, physicians have turned to older antibiotics, such as polymyxins, tetracyclines, and aminoglycosides. Lately, due to development of resistance to these agents, fosfomycin has gained attention, as it has remained active against both Gram-positive and Gram-negative MDR and XDR bacteria. New data of higher quality have become available, and several issues were clarified further. In this review, we summarize the available fosfomycin data regarding pharmacokinetic and pharmacodynamic properties, thein vitroactivity against susceptible and antibiotic-resistant bacteria, mechanisms of resistance and development of resistance during treatment, synergy and antagonism with other antibiotics, clinical effectiveness, and adverse events. Issues that need to be studied further are also discussed.

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Section: Activity In Biofilmsmentioning

confidence: 99%

Section: Susceptibility Reports (Gram-negative and Gram-positive Isolmentioning

confidence: 99%

Section: Susceptibility Reports (Gram-negative and Gram-positive Isolmentioning

confidence: 99%

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Fosfomycin

et al. 2016

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“…18 MRSA is considered an important problem in both hospital-and community-acquired infections. 19 In a study conducted by Falagas et al, 20 129 of 130 (99.2%) MRSA isolates and 745 of 961 (77.5%) MRCoNS isolates were susceptible to fosfomycin.…”

Section: 13mentioning

confidence: 99%

In vitro efficacy of fosfomycin against clinical strains

Karadağ¹

2014

Jmid

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Objective: Fosfomycin is an alternative drug for treatment of uncomplicated urinary tract infections. This study aimed to investigate in vitro activity of fosfomycin against methicillin-resistant Staphylococcus aureus (MRSA), methicillinresistant coagulase negative staphylococci (MRCoNS), vancomycin-resistant Enterococcus faecium (VR E. faecium), Escherichia coli, Klebsiella pneumoniae, and Enterobacter isolates. Methods:Clinical isolates of MRSA, MRCoNS, E. coli, K. pneumoniae and Enterobacter spp. and VRE isolates which were isolated from rectal swaps were identified with Vitek 2 Compact (Biomeriux, France) and BD Phoenix (BD USA) automated systems. The Kirby-Bauer disc diffusion method was used to determine the susceptibility to fosfomycin.Results: All the MRSA (n=40), MRCoNS (n=40), and VR E. faecium (n=62) isolates were susceptible to fosfomycin. The fosfomycin susceptibility rates for E. coli, K. pneumoniae, and Enterobacter spp. were 97.5% (39 of 40), 97.3% (36 of 37), and 86.9% (20 of 23), respectively. One (2.7%) isolate of K. pneumoniae and three (13.1%) isolates of Enterobacter spp. showed intermediate susceptibility to fosfomycin. Resistance to fosfomycin was detected in only one (2.5%) isolate of E. coli. Conclusion:Based on the results of our study, fosfomycin is highly active against a collection of several gram-positive and gram-negative bacteria, including multidrug resistant isolates, and is an alternative drug in the treatment option.

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“…Tek ba şı na fu si dik asit te da vi si sı ra sın da di renç geli şe bil di ği bi lin mek te dir. 8 Bu ça lış ma da, has ta ne en fek si yon la rı na neden olan MRSA, MRKNS ve en te ro kok izo lat ların da; li ne zo lid, dap to mi sin, te i kop la nin ve fu si dik asit (en te ro kok ha riç) an ti bi yo tik le ri için MİK de ğer le ri nin be lir le ne rek du yar lı lık la rı nın kar şı laş tı rıl ma sı amaç lan mış tır.…”

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In Vitro Susceptibilities of Staphylococcus and Enterococcus Isolates to Linezolid, Daptomycin, Teicoplanin and Fusidic Acid

Ertem¹,

Öztürk²,

Hatipoğlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Koagülaz negatif stafilokoklar (KNS), Staphylococcus aureus (S. aureus) ve enterokoklarda glikopeptid direnci giderek artmaktadır. Bu çalışmanın amacı, hastane kaynaklı metisiline dirençli stafilokok ve enterokok izolatlarının son yıllarda kullanıma giren linezolid ve daptomisin ile uzun zamandır kullanılan teikoplanin ve fusidik asit (enterokoklar hariç) için in vitro duyarlılığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hastane kaynaklı toplam 172 izolat [metisiline dirençli S. aureus (MRSA, n: 60), metisiline dirençli koagülaz negatif stafilokok (MRKNS, n: 60) ve MİK 90 değerleri daptomisin için (0,125 ve 1 mg/L) bulunurken, E. faecium izolatlarında değerler daptomisin, linezolid ve teikoplanin için birbirine yakın çıkmıştır (1 ve 1,5-2 mg/L). Stafilokok ve enterokok izolatlarında daptomisin ve linezolid direnci bulunmamıştır. Fusidik aside karşı MRSA izolatlarında %8,3, MRKNS izolatlarında %31,7 oranında direnç bulunmuştur. Tüm MRSA izolatları teikoplanine duyarlıyken, 7 MRKNS ve 1 E.faecalis izolatı orta duyarlı, 3 MRKNS (%5) ve 2 E. faecium (%10,5) izolatı ise teikoplanine dirençli bulunmuştur. S So on nu uç ç: : Stafilokoklarda teikoplanin direncinin düşük olması, ek olarak hem stafilokoklarda hem de enterokoklarda linezolid ve daptomisine karşı direnç bulunmaması sevindiricidir. Öte yandan MRKNS izolatlarında fusidik aside karşı direnç dikkat çekici düzeydedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Stafilokok; metisiline dirençli Staphylococcus aureus; enterokokus; ilaç direnci, bakteriyel A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Glycopeptide resistance is increasing among Staphylococcus aureus (S. aureus), coagulase negative staphylococci (CoNS) and enterococcus strains. The aim of our study was to evaluate of in vitro susceptibilities of nosocomial staphylococcus and enterococcus isolates to recently used antibiotics (linezolid, daptomycin) and long-standing used antibiotics (teicoplanin and fusidic acid, except for enterococci). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study was performed with 172 clinical isolates [methicillin resistant S. aureus (MRSA, n:60) and (methicillin resistant coagulase negative staphylococcus (MRCoNS, n:60) and enterococci (33 E. faecalis, 19 E. faecium)]. Identification of the bacteria was done by conventional methods while VITEK II compact system (bioMérieux, France) was also used for enterococci. R Re es su ul lt ts s: : The minimum inhibitory concentrations (MICs) of all antimicrobial agents were tested by E-test (AB bioMérieux, Sweden). In MRSA isolates, the lowest MIC 50 and MIC 90 values were found to daptomycin (0.064 and 0.125 mg/L) and fusidic acid (0.032 and 0.47 mg/L). In MRCoNS isolates, the lowest MIC 50 and MIC 90 values were as 0.038 mg/L and 0.38 mg/L for daptomycin. In E. faecalis isolates, the lowest values were 0.125 and 1 mg/L for daptomycin while in E. faecium isolates the values were similar (1 and 1.5-2 mg/L) for daptomycin, linezolid and t...

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In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus

Cited by 19 publications

References 24 publications

Fosfomycin

Fosfomycin

In vitro efficacy of fosfomycin against clinical strains

In Vitro Susceptibilities of Staphylococcus and Enterococcus Isolates to Linezolid, Daptomycin, Teicoplanin and Fusidic Acid

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