In vitro efficacy of fosfomycin against clinical strains

Karadağ, Adil

doi:10.5799/ahinjs.02.2014.02.0127

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Successful outcomes were reported in some studies by using fosfomycin intravenously for infections other than UTI, although fosfomycin has not been approved for conditions other than UTI. [16], [17], [18] Our study of susceptibility pattern of fosfomycin against drug resistant gram positive cocci like MRSA and gram negative bacilli like ESBL producing Escherichia coli and Klebsiella species, MBL Producers Pseudomonas aeruginosa correlates well with many studies.…”

Section: Discussionmentioning

confidence: 64%

“…In our study E. coli isolates were susceptible to fosfomycin 200µg/disc (100%) and also by agar dilution methods as per CLSI and EUCAST criteria. Studies conducted by Adil karadag etal, [18] Pullukcu H etal, [24] Endimiani etal, [25] Tharavichitkul etal [26] showed 97.5%, 96.5%, 99.4% and 97.3% respectively. All these studies support our findings and also fosfomycin has high susceptibility against carbapenem resistant E. coli (95.1%).…”

Section: Discussionmentioning

confidence: 99%

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Susceptibility Pattern of Fosfomycin Against Drug Resistant Bacteria Obtained from Non - Urinary Clinical Samples in a Tertiary Care Hospital, South India

Ethirajulau

Jeyakumari

Sankararaman

et al. 2018

APALM

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Background: Multi drug resistance (MDR) in bacterial infections has been an ever growing problem worldwide. To combat this some of the old drugs like fosfomycin used in the past are revived. The aim of our study was to determine the susceptibility of fosfomycin against Methicillin sensitive and Resistant Staphylococcus aureus, ESBL producing Escherichia coli, Klebsiella species and Metallo Beta Lactamase producing Pseudomonas aeruginosa isolated from the specimens other than urine and to evaluate the agreement between the two methods, disk diffusion and agar dilution methods performed as per CLSI guidelines. Methods: First isolate of each species per patient (n=250) were tested for susceptibility to fosfomycin concomitantly by the disk diffusion and agar dilution methods described by CLSI guidelines and comparison of the two methods were studied. Result: Staphylococcus aureus and ESBL E. coli were showing 100% susceptibility, Whereas ESBL producing Klebsiella species showed 88% susceptibility to fosfomycin 200 µg/disc and 80% and 72% by agar dilution method as per CLSI and EUCAST criteria. For MBL producing Pseudomonas aeruginosa, 90% isolates were susceptible to fosfomycin 200 µg/disc and in agar dilution (60%) (≤32µg/ml) were susceptible as per EUCAST criteria. Disk diffusion method showed good agreement for S.aureus and E.coli whereas moderate agreement for Klebsiella species and very poor for Pseudomonas aeruginosa. Conclusion: Fosfomycin can be considered as an alternate drug to treat infections with multi drug resistant bacteria, not only for the UTI but for systemic infections also. This is achievable with establishment of breakpoint values and zone diameter for all common isolates.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Susceptibility Pattern of Fosfomycin Against Drug Resistant Bacteria Obtained from Non - Urinary Clinical Samples in a Tertiary Care Hospital, South India

Ethirajulau

Jeyakumari

Sankararaman

et al. 2018

APALM

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show abstract

“…We read a review article published by Karadağ et al [1] on the use of Fosfomycin as an alternative to treat gram-positive and gramnegative bacteria, including multidrug resistant isolates. Intravenous (IV) fosfomycin has been shown to be a safe and effective alternative in treating infections outside of the urinary and gastrointestinal tract [2].…”

mentioning

confidence: 99%