In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy

Voss, Reinhard; Geißler, Bastian; Tillmanns, Harald; Fr, Matthias

doi:10.1016/0049-3848(93)90172-k

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Several methods have been used to investigate this phenomenon (9,11,12). An insufficient effect of dose or administration of aspirin may have important clinical consequences, as shown in post-stroke patients (14), where secondary aspirin nonresponders had significantly more events than responders to the therapy.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Different Antithrombotic Regimens on Platelet Aggregation After Myocardial Infarction

Hurlen

Seljeflot²,

Arnesen³

1998

Scandinavian Cardiovascular Journal

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Platelet aggregate ratio (PAR) was measured according to the method of Wu & Hoak in 143 patients after acute myocardial infarction (AMI) and in 54 controls. A PAR < 1 expresses the presence of platelet aggregates. The patients were randomized to aspirin 160 mg/d, or warfarin, or aspirin 75 mg/d + warfarin. In patients on aspirin, PAR was measured 24 h after aspirin intake, and in 76 patients also 2 h after aspirin. The median PAR in patients on warfarin was 0.85, on warfarin + aspirin 0.91 and on aspirin alone 0.94, all significantly lower than the median PAR of 0.97 in the controls. In 14 patients on aspirin the PARs were below a cut-off point of 0.82 (secondary aspirin non-responders). PAR increase significantly 2 h after aspirin intake. In two patients, however, PAR remained low (primary aspirin non-responders). It is concluded that some patients do not seem to respond to aspirin, the clinical implication of which has yet to be determined.

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Section: Discussionmentioning

confidence: 99%

“…Thus, in coronary heart disease aspirin is now administered once daily in low doses. However, the occurrence of non-responsiveness to aspirin and development of aspirin resistance has been described, suggesting a cyclooxygenase-independent activation of platelets (9)(10)(11)(12).…”

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confidence: 99%