In vitro and in silico analysis of the predicted human MOB gene encoding a phylogenetically conserved transmembrane protein

Vladychenskaya, Irina P.; Dergunova, Lyudmila V.; Limborska, Svetlana A.

doi:10.1016/s1389-0344(01)00110-1

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…60 Structural and functional analysis of its transcripts predicted regulation at both transcriptional and translational level. 60,61 Subsequently, several alternative spliced products of SMS1 were found both in human cerebellum and in the mouse 62 suggesting complex regulation for SMS1 expression.…”

Section: Sms Cloning Strategiesmentioning

confidence: 99%

“…64 A remarkable difference between the two SMS isoforms is that SMS1, but not SMS2, contains a N-terminal Sterile Alpha Motif or SAM domain. 58,60 SAM domains have been shown to homoand hetero-oligomerize, forming multiple self-association architectures. They can also associate with various non-SAM domain-containing proteins and appear to possess the ability to bind RNA.…”

Section: Structural Organization and Reaction Chemistry Of Sms Familymentioning

confidence: 99%

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Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

Holthuis

Luberto

2010

Advances in Experimental Medicine and Biology

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In the last five years tremendous progress has been made toward the understanding of the mechanisms that govern sphingomyelin (SM) synthesis in animal cells. In line with the complexity of most biological processes, also in the case of SM biosynthesis, the more we learn the more enigmatic and finely tuned the system appears. Therefore with this review we aim first, at highlighting the most significant discoveries that advanced our knowledge and understanding of SM biosynthesis, starting from the discovery of SM to the identification of the enzymes responsible for its production; and second, at discussing old and new riddles that such discoveries pose to current investigators.

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Section: Sms Cloning Strategiesmentioning

confidence: 99%

Section: Structural Organization and Reaction Chemistry Of Sms Familymentioning

confidence: 99%

Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

Holthuis

Luberto

2010

Advances in Experimental Medicine and Biology

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“…1B). Previously, MOB was reported to consist of seven exons (Vladychenskaya et al, 2002) represented by exons V -XI of the newly reported gene structure. Exons I, II, III and IV emerged from the newly discovered part of the transcript.…”

Section: In Silico Construction Of the Extended Mob Transcript And Vmentioning

confidence: 96%

“…It codes for a putative transmembrane protein 'Mob' of 413 amino acids (Vladychenskaya et al, 2002).…”

Section: Analysis Of the Constructed Mob Transcriptmentioning

confidence: 99%

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Human gene MOB: structure specification and aspects of transcriptional activity

Vladychenskaya

Dergunova

Dmitrieva

et al. 2004

Gene

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Comparative analysis of sphingomyelin synthase 1 gene expression at the transcriptional and translational levels in human tissues

et al. 2015

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Sphingomyelin synthase 1 (SMS1) catalyses the biosynthesis of sphingomyelin in eukaryotic cells. We have previously determined the structure of the SGMS1 gene encoding this enzyme and a number of its alternative transcripts. Here, we describe a study of the expression of the full-length SMS1 protein and the sum of the alternative transcripts encoding this protein in human tissues. The SMS1 protein and mRNA levels in tissues differed significantly and were not correlated, implying the active post-transcriptional regulation of SMS1 protein expression. The putative truncated isoforms of the SMS1 protein, which are encoded by a number of alternative transcripts, were not detected by immunoblotting and thus may be absent or present in only small amounts.

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In vitro and in silico analysis of the predicted human MOB gene encoding a phylogenetically conserved transmembrane protein

Cited by 11 publications

References 14 publications

Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

Human gene MOB: structure specification and aspects of transcriptional activity

Comparative analysis of sphingomyelin synthase 1 gene expression at the transcriptional and translational levels in human tissues

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