In vitro and In vivo Characterization of Pectin Based In situ Gelling System of Famotidine

Modasiya, Mohmadmoin K.; Patel, Anand; Patel, Vineetkumar; Patel, Ghanshyam

doi:10.37285/ijpsn.2012.5.4.9

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…Based on the study, it was observed that formulation with HPMC shown satisfactory floating behaviors. 36,37 and it is shown in Tables 3 and 4.…”

Section: In Vitro Floating Studies Of Carvedilol Floating In Situ Gelmentioning

confidence: 99%

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Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability

Ramalingam,

Sukumaran,

Krishnan

2024

Ind. J. Pharm. Edu. Res

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Background/Aim: The purpose of this study was to design and prepare floating in situ gel to sustain Carvedilol (CVD) release and enhance oral bioavailability. Various floating in situ gel formulations of the CVD were prepared by ionic gelation method. Materials and Methods: A systematic approach in the design of the formulations was adopted, were using Hydroxypropyl Methyl Cellulose (HPMC K4M), Hydroxypropyl Methyl Cellulose (HPMC 100LV), Sodium alginate, Mimosa pudica seed mucilage and Limonia acidissima gum in various concentrations along with gas generating agent (sodium bicarbonate) were investigated for its physicochemical properties (in vitro floating behavior, drug release profile, etc.). Subsequently, a final optimization step is involved based on the physicochemical properties to achieve the desired effect. Results: Based on the study, the formulation with HPMC K4M, HPMC 100LV, Sodium alginate, and Mimosa pudica seed mucilage (F17) showed good floating properties (60 sec floating lag time) with drug release of 96.98 ± 2.1% for 12 hr and the drug release mechanism was found to be zero order (R 2 = 0.894). In vivo X-ray studies of F17 in albino rabbits showed a good floating ability up to 8 hr. Bioavailability of optimized and control (CARLOC) was found to be 41.95 ± 0.8892 μg.hr/ mL and 26.36 ± 1.1603 μg.hr/mL respectively. The accelerated stability study was performed with optimized formulation and it was observed stable during the study. Conclusion: It was concluded that the floating in situ gel of Carvedilol developed with natural polymer is suitable for GRDDS to enhance oral bioavailability.

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“…Based on the study, it was observed that formulation with HPMC shown satisfactory floating behaviors. 36,37 and it is shown in Tables 3 and 4.…”

Section: In Vitro Floating Studies Of Carvedilol Floating In Situ Gelmentioning

confidence: 99%

“…Gelling capacity was graded based on the gelation time and time for which formed gel retained. 36,37 + Gelation after few minutes dispersed rapidly ++ Gelation immediate remains for few hours +++ Gelation immediate remains for an extended period…”

Section: In Vitro Gelationmentioning

confidence: 99%

Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability

Ramalingam,

Sukumaran,

Krishnan

2024

Ind. J. Pharm. Edu. Res

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“…Bench top digital pH meter was calibrated with standard buffer solutions of pH 4, 7 and 10 before the determination of the pH of trial gel formulations. Dispersions of trials were prepared by adding 1gm of gel content in 100mL of deionized water (Modasiya, Prajapati et al, 2015). The pH of the trials was noted in triplicate.…”

Section: Ph Determinationmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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The present study was designed to formulate a 5% topical gel formulation containing dexibuprofen. Herein, we reported the utilization of different gelling polymers including hydroxyl propyl methyl cellulose (HPMC), carboxy methyl cellulose (CMC), carbopol 940 and leutrol F127 at three concentration levels. Overall, twelve trials (TD1 to TD12) were prepared in four batches (DEX-I to DEX-IV), each having three trial dexibuprofen gel formulations. All formulations were evaluated for organoleptic properties, clarity, pH, consistency, viscosity and spreadability. Trials of DEX-I and DEX-III batches (containing HPMC and carbopol 940polymers respectively), were a lack in smoothness, clarity and viscosity. Contra wise, TD5, TD6 dexibuprofen gel formulations of batch DEX-II and TD10, TD11 and TD12 of DEX-IV having CMC and lutrol ® F127 correspondingly were found to be viscous and free from grittiness and precipitation. In vitro drug kinetics revealed the Weibull kinetic model as the best (r 2 >0.999, AIC 31. . Stability testing was performed on the selected formulations (TD5, TD6, TD10, TD11 and TD12) having acceptable physicochemical attributes. Only TD11 and TD12 were found to be stable at room temperature after three months. Based on the findings, it is concluded that lutrol ® F127 based dexibuprofen gel formulations delivered excellent spreadability, better drug release, and satisfactory stability profile.

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“…The molecular weight and solubility of XNT are 218.33 g/ mol and 28.90 μg/ml, respectively. This makes XNT have lower molecular weight and higher solubility compared with bioactive compound curcumin [60,61]. Thus, it was expected that XNT might easily penetrate the surface of biofilm.…”

Section: Xanthorrhiza Roxb Extraction Preparationmentioning

confidence: 99%

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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Most common oral diseases are directly related to oral biofilm, a complex community of microorganisms inhibiting the oral cavity. Recent studies provide deeper knowledge on how free-floating bacteria form a structurally organized microecosystem and on its pathogenicity and its self-defense mechanisms; thus, creating an understanding of the challenges in eliminating oral biofilm and maintaining the balance of oral ecosystem. Chlorhexidine has been the standard oral antimicrobial agent for decades. However, studies showed that it is less effective against bacteria in the form of biofilm that leads to an ongoing search of another method to fight against biofilm, including the use of plant-derived compounds. Medicinal plants are known to contain secondary metabolites, which are not only important in protecting the plant from any harmful environment but also potential as antimicroorganism and antioral biofilm for humans. Curcuma xanthorrhiza Roxb., containing xanthorrhizol (XNT), an essential bioactive compound, is an Indonesian native medicinal plant proven to have antibacterial and antibiofilm activities by several in vitro studies. The understanding of biofilm formation, its resistance to common drugs, and the potential role of C. xanthorrhiza-derived compounds as antibacterial and antibiofilm may contribute to developing C. xanthorrhiza into the alternative weapon against oral biofilm-related diseases.

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In vitro and In vivo Characterization of Pectin Based In situ Gelling System of Famotidine

Cited by 6 publications

References 15 publications

Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability

Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability

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Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

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