In Vitro and in Vivo Estrogenicity of UV Screens

Schlumpf, Margret; Cotton, Bea; Conscience, Marianne; Haller, Vreni; Steinmann, B; Lichtensteiger, W.

doi:10.2307/3434691

Cited by 136 publications

(207 citation statements)

References 15 publications

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“…However, the chronic toxicity of these compounds is still a concern, which requires further investigation (Kadar et al, 2010;Harris et al, 2007;Farre et al, 2008). Some UV filters such as 3-(4-methylbenzylidene) camphor (4-MBC) and octyl 4-methoxycinnamate (OMC) have exhibited adverse biological effects due to their hormonal activities (estrogenic, antiestrogenic, androgenic and antiandrogenic) as demonstrated in both in vitro and in vivo tests (Schlumpf et al, 2001;Heneweer et al, 2005;Maerkel et al, 2005;Kunz and Fent, 2006;Klammer et al, 2007). A major source of BTs and UV filters is the release of effluent and sludge from wastewater treatment plants (WWTPs).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant

Liu

Ying

Shareef

et al. 2012

Environmental Pollution

228

103

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Section: Introductionmentioning

confidence: 99%

Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant

Liu

Ying

Shareef

et al. 2012

Environmental Pollution

228

103

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“…Consequently, BP-3 reaches aquatic environments directly through recreational activities (swimming and bathing) and indirectly by way of wastewater treatment plants (WWTPs) because of incomplete removal [2,5,6]. It is reported that BP-3 showed hormonal activities (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in fish in both in vitro and in vivo tests [7][8][9]. In male medaka and male California halibut BP-3 lead to vitellogenin induction [10,11].…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of the ultraviolet filter benzophenone‐3 under different redox conditions

Liu

Ying

Shareef

et al. 2011

Enviro Toxic and Chemistry

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Abstract-Biodegradation of the ultraviolet (UV) filter benzophenone-3 (BP-3) was investigated in the laboratory to understand its behavior and fate under oxic and anoxic (nitrate, sulfate, and Fe [III]-reducing) conditions. Biodegradation experiments were conducted in microcosms with 10% of activated sludge and digested sludge under oxic and anoxic conditions, respectively. Benzophenone-3 was well degraded by microorganisms under each redox condition. Under the redox conditions studied, the biodegradation half-life for BP-3 had the following order: oxic (10The results suggest that anaerobic biodegradation is a more favorable attenuation mechanism for BP-3. Biodegradation of BP-3 produced two products, 4-cresol and 2,4-dihydroxybenzophenone, under oxic and anoxic conditions. Biotransformation of BP-3 to 2,4-dihydroxybenzophenone by way of demethylation of the methoxy substituent (O-demethylation) occurred in cultures under each redox condition. The further biotransformation of 2,4-dihydroxybenzophenone to 4-cresol was inhibited under oxic, nitrate-reducing, and sulfate-reducing conditions. Environ. Toxicol. Chem. 2012;31:289-295. # 2011 SETAC

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“…Both the primary compound and its metabolites are excreted in urine in the form of glucuronated derivatives (Okereke et al, 1993;Kadry et al, 1995;Calafat et al, 2008). BP3 has low acute toxicity , but it shows estrogenic activity in several fish species, where it acts as vitellogenin inducer (Schlumpf et al, 2001;Schlenk et al, 2005;Kunz et al, 2006;Coronado et al, 2008). Therefore, BP3 has potential to cause feminisation of male fish.…”

Section: Introductionmentioning

confidence: 99%

Phototransformation of the sunlight filter benzophenone-3 (2-hydroxy-4-methoxybenzophenone) under conditions relevant to surface waters

Vione

Caringella

Laurentiis

et al. 2013

Science of The Total Environment

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. Phototransformation of the sunlight filter benzophenone-3 (2-hydroxy-4-methoxybenzophenone) under conditions relevant to surface waters. Sci. Total Environ. 2013, 463-464, 243-251. DOI: 10.1016/j.scitotenv.2013 You may download, copy and otherwise use the AAM for non-commercial purposes provided that your license is limited by the following restrictions:(1) You may use this AAM for non-commercial purposes only under the terms of the CC-BY-NC-ND license.(2) The integrity of the work and identification of the author, copyright owner, and publisher must be preserved in any copy. AbstractThe UV filter benzophenone-3 (BP3) has UV photolysis quantum yield s −1 ), the CO 3 −• degradation process could be somewhat important for DOC < 1 mg C L −1 . The predicted half-life time of BP3 in surface waters under summertime conditions would be of some weeks, and it would increase with increasing depth and DOC. BP3 transformation intermediates were detected upon reaction with • OH. Two methylated derivatives were tentatively identified, and they were probably produced by reaction between BP3 and fragments arising from photodegradation. The other intermediates were benzoic acid (maximum concentration ∼10% of initial BP3) and benzaldehyde (1%).

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In Vitro and in Vivo Estrogenicity of UV Screens

Cited by 136 publications

References 15 publications

Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant

Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant

Biodegradation of the ultraviolet filter benzophenone‐3 under different redox conditions

Phototransformation of the sunlight filter benzophenone-3 (2-hydroxy-4-methoxybenzophenone) under conditions relevant to surface waters

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