In vitro and in vivo validation of a new three‐dimensional fringe projection‐based device (AEVA‐HE) dedicated to skin surface mapping

Abstract

Background: Aging signs are much visible on the surface of the skin that presents different changes: cheeks start to sag, more and deeper wrinkles appear, and pigmentation spots increase. Face diagnostic to recommend products includes assessing cutaneous micro-relief or the micro-depressive network on the face. Furthermore, there is an increasing demand for clinical and instrumental methods to prove the efficacy of anti-aging treatments. As a result, very accurate and sensitive three-dimensional (3D) devices are developed and validated to measure and quantify aging skin and to catch fine anti-aging products acting on wrinkles and fine lines.Methods: AEVA-HE, a non-invasive 3D method based on fringe projection technology, is used to robustly characterize the skin micro-relief from a full-face acquisition and from multiple extracted zones of interest. In vitro and in vivo studies are conducted to assess the reproducibility of this system and its precision toward a standard fringe projection system, DermaTOP. Results:The AEVA-HE successfully measured micro-relief and wrinkles and demonstrated the reproducibility of measurements. AEVA-HE parameters were found highly correlated to DermaTOP. Conclusion:The present work illustrates the performance of the AEVA-HE device and its dedicated software kit as a precious tool for quantifying the major characteristics of wrinkles appearing with age and thus offers a high potential for assessing the effect of anti-wrinkling products.

Applications of the new Aeva‐HE™ imaging system: Its link with the visual evaluation of facial wrinkles and its potential in screening tensile products

“…A previous paper 33 showed that this recently developed device 34 provides data of a good similarity with those obtained by the Dermatop™ Instrument. Accordingly, the potential of this new Aeva‐HE™ device to correlate with expert's evaluations and to being integrated in the screening process of prototypes of anti‐aging products, needed to be explored.…”

“…The study involved the same 85 French Caucasian women who participated in the first study 33 . These women were clustered in age‐groups: 25–39 y ( N = 7), 40–49 y ( N = 18), 50–55 y ( N = 23), 56–60 y ( N = 15), and 61–71 y ( N = 22).…”

“…The study involved the same 85 French Caucasian women who participated in the first study. 33 These women were clustered in age-groups: Subjects were informed about the respective purpose and protocol of the study and signed an informed consent. Prior to photographic shootings, one day of wash out was requested to all subjects to avoid the impact of their usual cleansing routines and skin care products on the result of the study.…”

Analysis of images supplied by Skincam® can record the changes of some scar features that occur over time. Comparisons with the assessments of dermatologist and patients' perception

“…As nomad device, it allows a usage outside laboratories or consulting rooms contrary to some existing methods 17–19 . The relevance between objective measurements acquired with the SkinCam® device and the self‐perception of the volunteers is an important and sincere link/relationship between patients and scientific demonstration, possibly adapted to teleconsultation in the future.…”

“…As nomad device, it allows a usage outside laboratories or consulting rooms contrary to some existing methods. [17][18][19] The relevance Beyond scars, extending its use to monitor dynamic pathologies such as acne, 24 to follow its severity and a possible identification of lesions (including scarring acne) is a promising approach to follow and adjust treatment between visits. Such aspect is currently in progress and its findings will be the object of a future paper.…”