In vitro and in vivo evaluation of four co-trimoxazole oral suspensions

Ezzedeen, F.W.; Majeed, S.H.; Shihab, F.A.; Mahmoud, M.J.; Robinson, Dennis H.; Tahseen, Yildiz H.; Stohs, Sidney J.

doi:10.1016/0378-5173(90)90116-l

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…If in vitro dissolution evaluation is a priority for the latter, it is logical to extend the requirement to suspensions as a limiting step to absorption and bioavailability (6)(7)(8). However, fewer than 10% of codified oral suspensions have a dissolution test described (9,10), and to the best of our knowledge, among the few studies carried out on suspension dissolution, almost none of them consider changes in dissolution during the administration period of the reconstituted form (11)(12)(13)(14)(15)(16)(17)(18). If a product is stored under the conditions specified on the label, it is expected to maintain its initial dissolution behavior throughout its life, which is known as Dissolution Stability (19).…”

Section: Introductionmentioning

confidence: 99%

Dissolution Stability of Cephalexin Extemporaneous Suspensions During an Accelerated Stability Study

Brevedan¹,

Varillas²,

Vidal³

2012

Dissolution Technol.

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The aim of the present study was to evaluate the influence of accelerated aging conditions on drug content and in vitro dissolution stability of three cephalexin (CE) extemporaneous suspensions obtained from pharmacies and a local state laboratory. The specific gravity, pH, and visual appearance of CE oral extemporaneous suspension were also studied. Dissolution profiles were performed according to FDA recommendations, since there is no official dissolution method codified. Analyses were performed throughout the administration period of the reconstituted suspension (7 days at room temperature storage or 14 days under refrigeration), at time zero, and during twelve months of storage of the powders under ICH accelerated aging conditions. Dissolution Efficiency (DE) values and assay results were analyzed via analysis of variance (ANOVA) to evaluate the effect of aging conditions on the stability of each formulation. From a clinical point of view, the storage conditions applied did not affect dissolution or chemical stability of CE oral extemporaneous suspensions.

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Section: Introductionmentioning

confidence: 99%

Dissolution Stability of Cephalexin Extemporaneous Suspensions During an Accelerated Stability Study

Brevedan¹,

Varillas²,

Vidal³

2012

Dissolution Technol.

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show abstract

Enzyme immunoassays for the detection of sulfamethazine, sulfadiazine, sulfamethoxypyridazine and trimethoprim in milk

Märtlbauer

Meier

Usleber

et al. 1992

Food and Agricultural Immunology

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Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions

Vidal¹,

Zubata²,

Simionato³

et al. 2008

Dissolution Technol.

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Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous disperse systems (suspensions) could also have some problems with their in vitro dissolution.The dissolution behavior of four different brands of cefadroxil extemporaneous suspensions available in the Argentinian market was evaluated. The deliverable volume, pH, visual appearance, uniformity of dosage units, and assay were also studied.Powders for oral suspension were stored under different aging conditions. Samples at room temperature and refrigerated conditions were taken at several time points to carry out the dissolution stability study during the expiration period of the reconstituted form. Marked differences were recorded with respect to in vitro dissolution behavior between the different products under evaluation.

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In vitro and in vivo evaluation of four co-trimoxazole oral suspensions

Cited by 7 publications

References 8 publications

Dissolution Stability of Cephalexin Extemporaneous Suspensions During an Accelerated Stability Study

Dissolution Stability of Cephalexin Extemporaneous Suspensions During an Accelerated Stability Study

Enzyme immunoassays for the detection of sulfamethazine, sulfadiazine, sulfamethoxypyridazine and trimethoprim in milk

Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions

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