Purpose To evaluate the residual surface roughness of 5 common diamond-coated interproximal reduction (IPR) systems after consecutive in vitro applications in relation to system, diamond grain size, and instrument thickness. Methods IPR was performed on 80 extracted human incisors using motor-driven strips and discs under predefined conditions. The IPR auxiliaries were applied at 5 consecutive sessions of 20 s on intact interproximal surfaces, and the surface profile (Ra, Rz, Rmax) was analyzed at baseline and after each session with an optical profilometer. Results No overall significant difference in the roughness values was found between systems (P = 0.07 for Ra, P = 0.33 for Rz, and P = 0.48 for Rmax). There was a significant average decrease of Ra, Rz, and Rmax for all systems for every unit increase in time by-0.171 μm (P < 0.001),-3.297 (P Ä 0.001), and-2.788 μm (P = 0.001), respectively. Ra, Rz, and Rmax values increased significantly, i.e., by 0.194 μm (P = 0.003), 5.890 μm (P = 0.001), and 5.319 μm (P = 0.010) as instrument thickness increased by one unit. No significant reductions in Ra, Rz, and Rmax were observed across grain sizes (-0.008 μm [P > 0.05],-0.244 μm [P > 0.05], and-0.179 μm [P > 0.05], respectively). There was no evidence of interaction between system and time as the P values for Ra, Rz, and Rmax were 0.88, 0.51, and 0.70, respectively. Conclusions All IPR materials presented significant gradual decrease of surface roughness after repeated applications. There were no significant roughness changes among auxiliaries of different grain sizes. Thinner auxiliaries showed significantly more roughness reduction, possibly requiring more frequent replacement than thick auxiliaries in clinical practice. Keywords Dental high-speed technique • Surface roughness • Optical profilometer • Dental enamel • Enamel stripping methods Quantitative Untersuchung der fortschreitenden Abnutzung elektrisch angetriebener Interproximal-Reduktionssysteme bei wiederholter Anwendung Eine In-vitro-Studie Zusammenfassung Ziel Beurteilt werden sollte die verbleibende Oberflächenrauigkeit von 5 handelsüblichen diamantbeschichteten Interproximal-Reduktionssystemen nach wiederholter In-vitro-Anwendung, differenziert wurde dabei bezüglich System, Diamantkorngröße und Instrumentendicke.