2018
DOI: 10.1177/0883911518774814
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In vitro and in vivo evaluation of porous chitosan electret membrane for bone regeneration

Abstract: A porous chitosan electret membrane, possessing a three-dimensional porous structure and surface charges, was developed using thermally induced phase separation method and gridcontrolled corona charging. Results showed that surface charge release of porous electret membrane could be altered by varying charging voltage. Rat osteoblasts adhered well, and cell proliferation and differentiation were enhanced by porous electret membrane compared to porous uncharged membrane. Furthermore, rabbit calvarial defects mo… Show more

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Cited by 6 publications
(4 citation statements)
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“…However, evidence on the use of electret materials to promote bone repair is still lacking, which requires further extensive research on this subject. In previous studies, chitosan electret membranes were prepared and demonstrated to be effective in promoting osteoblast function in vitro and in inducing bone healing in vivo . E-S/P membranes developed in this study showed comparable or even better bone repair facilitating effects in terms of preparation facility, application convenience, electrical stability, stimulus persistency, and osteopromotive efficiency, thereby holding promising prospects for bone tissue engineering applications.…”
Section: Resultsmentioning
confidence: 71%
“…However, evidence on the use of electret materials to promote bone repair is still lacking, which requires further extensive research on this subject. In previous studies, chitosan electret membranes were prepared and demonstrated to be effective in promoting osteoblast function in vitro and in inducing bone healing in vivo . E-S/P membranes developed in this study showed comparable or even better bone repair facilitating effects in terms of preparation facility, application convenience, electrical stability, stimulus persistency, and osteopromotive efficiency, thereby holding promising prospects for bone tissue engineering applications.…”
Section: Resultsmentioning
confidence: 71%
“…Furthermore, calcium-induced signaling pathways were activated, which significantly promoted the osteogenic differentiation of BMMSCs in vitro and the bone regeneration effect in vivo ( Figure 4 D). In another study, the porous CS electret films were prepared by Wang et al for bone regeneration [ 98 ]. The in vitro results showed that when porous electret films were cultured with rat osteoblasts, cell proliferation, and differentiation were significantly enhanced compared with porous uncharged films.…”
Section: Biomedical Applicationsmentioning
confidence: 99%
“…In addition, the interstitial position of the porous electret can provide an ideal position to capture charge and increase electrical stability. Wang et al developed a CS electret porous film with a 3D porous structure using thermally-induced phase separation and a gridcontrolled corona charging method [98]. Firstly, CS powder was dissolved in acetic acid, filtered, cross-linked with glutaraldehyde, and then lyophilized at −80 • C. Subsequently, the acidity of the cross-linking solution was neutralized by soaking the porous film with NaOH.…”
Section: Chitosan (Cs)mentioning
confidence: 99%
“…However, the reported discrete electrostimulation based on piezoelectric and triboelectric wearable devices must be driven by the regular or irregular spontaneous motions of organisms ( 28 , 29 ), limiting the healing effect of the wound site without experiencing frequent activities. Electrical intervention based on electrets has been applied for wound healing and fracture repair, and the voltage decay of the external static electric field limits the long-term operation ( 30 , 31 ). In addition, mechanical contraction regulation can inhibit or promote vascularization depending on the strain magnitudes.…”
Section: Introductionmentioning
confidence: 99%