In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

Liao, Shu-Chuan; Chen, Chih‐Ying; Hsu, Yu-Hsuan; Li, Chi-Ting; Hsieh, Cheng-Chi; Tsai, Ming-Shiun; Chan, Man-Yee; Lee, Cheng-Hung; Wang, Sue-Hong; Ng, Shang-Kok; Tsou, Hsi‐Kai; Wu, Wan-Yu

doi:10.1016/j.surfcoat.2020.125814

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…Moreover, using thermal techniques to coat a low melting point polymer such as zein cannot be considered [22]. Similarly, RF Sputtering has been widely used for bio ceramic coatings such as HA [10], Si-CaP [11], Hopeite [23] and TiN [24], etc. The main limitation is the requirement of post-deposition annealing due to the formation of coatings with low crystallinity character [25].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Zein/Hydroxyapatite Composite Coatings for Biomedical Applications

2020

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Stainless steel is renowned for its wide use as a biomaterial, but its relatively high corrosion rate in physiological environments restricts many of its clinical applications. To overcome the corrosion resistance of stainless steel bio-implants in physiological environments and to improve its osseointegration behavior, we have developed a unique zein/hydroxyapatite (HA) composite coating on a stainless steel substrate by Electrophoretic Deposition (EPD). The EPD parameters were optimized using the Taguchi Design of experiments (DoE) approach. The EPD parameters, such as the concentration of bio-ceramic particles in the polymer solution, applied voltage and deposition time were optimized on stainless steel substrates by applying a mixed design orthogonal Taguchi array. The coatings were characterized by using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and wettability studies. SEM images and EDX results indicated that the zein/HA coating was successfully deposited onto the stainless steel substrates. The wettability and roughness studies elucidated the mildly hydrophilic nature of the zein/HA coatings, which confirmed the suitability of the developed coatings for biomedical applications. Zein/HA coatings improved the corrosion resistance of bare 316L stainless steel. Moreover, zein/HA coatings showed strong adhesion with the 316L SS substrate for biomedical applications. Zein/HA developed dense HA crystals upon immersion in simulated body fluid, which confirmed the bone binding ability of the coatings. Thus the zein/HA coatings presented in this study have a strong potential to be considered for orthopedic applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Zein/Hydroxyapatite Composite Coatings for Biomedical Applications

2020

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“…With an increase in the cultivation duration on TiN coatings, the number of cells rapidly increases and they completely cover the sample [17]. TiN deposited using a high-power pulsed magnetron sputtering technique exhibits high polarization resistance in simulated body fluid and demonstrates excellent MG63 osteoblast-like cell viability [19]. Analysis of the cytocompatibility of thin TiBN films showed increased compatibility with cells and toxicity of these coatings [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility Assessment of Coatings Obtained in Argon and Nitrogen Atmospheres for TiNi Materials

Марченко

Baigonakova

Kokorev

et al. 2022

Metals

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This work aims to study the cytocompatibility of protective coatings obtained in argon and nitrogen atmospheres on a TiNi surface. Particular attention is paid to comparing the interaction of cell culture with coatings and an uncoated TiNi sample, using for comparison the number of viable cells on the surface, the phase composition, structure, wettability, surface charge and topography. The Ti/Ni/Ti nanolaminate was deposited on a TiNi substrate by magnetron sputtering. Reaction annealing of Ti/Ni/Ti nanolaminate on a TiNi substrate, when heated to 900 °C in argon, leads to the formation of a dense two-layer coating 2.0–2.1 μm thick: layer I (TiO + Ti2N), layer II (Ti4Ni2 O(N)). Reaction annealing in nitrogen leads to the formation of a thin three-layer nanocoating 250 nm thick: I (TiO2 + TiN), II (Ti4Ni2N(O) + Ti3Ni4), III (TiN). The coating synthesized in nitrogen is more favorable for cell attachment and proliferation because of the moderately hydrophilic rough surface and mixed phase composition of titanium nitrides and oxides.

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“…The lower energy of the atoms arriving to the substrate gives origin to pronounced shadowing effects resulting in open intercolumnar porosity [16,20,21]. Nevertheless, only few recent works in literature are devoted to the preparation of coatings on implants [19,[22][23][24] and, in particular, applied to powder metallurgy substrates.…”

Section: Introductionmentioning

confidence: 99%

Ti6al4v Coatings on Titanium Samples by Sputtering Techniques Microstructural and Mechanical Characterization

Sánchez-López¹,

Rodriguez-Albelo²,

Sánchez-Pérez³

et al. 2022

SSRN Journal

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In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

Cited by 13 publications

References 28 publications

Fabrication and Characterization of Zein/Hydroxyapatite Composite Coatings for Biomedical Applications

Fabrication and Characterization of Zein/Hydroxyapatite Composite Coatings for Biomedical Applications

Biocompatibility Assessment of Coatings Obtained in Argon and Nitrogen Atmospheres for TiNi Materials

Ti6al4v Coatings on Titanium Samples by Sputtering Techniques Microstructural and Mechanical Characterization

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