In Vitro and In Vivo Biological Evaluation of O-Carboxymethyl Chitosan Encapsulated Metformin Nanoparticles for Pancreatic Cancer Therapy

Snima, K. S.; Jayakumar, R.

doi:10.1007/s11095-014-1425-0

Cited by 34 publications

(31 citation statements)

References 38 publications

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“…As previously mentioned, certain physicochemical factors influencing the toxicity of NPs, can be controlled thus reducing or even eliminating the toxicity of NPs. This was confirmed by previous studies showing that certain NPs with low toxic components, surface coatings and/or certain concentrations have no adverse effect to majority organs in mammals (Snima, Jayakumar, & Lakshmanan, ; Hauck, Anderson, Fischer, Newbigging, & Chan, ; Nurunnabi et al, ).…”

Section: Discussionsupporting

confidence: 77%

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Review of the effects of manufactured nanoparticles on mammalian target organs

Wu¹,

Tang

2017

J of Applied Toxicology

193

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Nanotechnology had matured significantly during the last two decades as it has transitioned from bench top science to applied technology. Even though the issue of safety of nanotechnology has been raised nearly one decade ago, the rapid progress in development and use of nanomaterials has not yet been matched by toxicological investigations. Many recent studies have simply outlined the toxic effects of nanoparticles (NPs), but few have systematically addressed their potentially adverse biological effects on target organs. Some animal models have shown that NPs could be accumulated in various organs. These accumulations can access the vasculature and target other organs, resulting in a potential health risks. After the brief description of current knowledge on the wide applications of several common NPs, their applications and the toxicokinetics, this review focused on effects of NPs on organ functions and mammal health after acute or chronic exposure, and potential mechanisms of action. Due to their physical properties, the liver, kidneys and lung are the main target organs of NPs. Most of NPs show slight toxicity when exposed to animals, while certain toxic effects like oxidative stress generation, inflammation and DNA damage are commonly observed. The severity of NPs toxicity is dependent upon several factors, including exposure dose and administration, NPs chemistry, size, shape, agglomeration state, and electromagnetic properties, which could provide useful information necessary to control the toxicity of NPs. Finally, the safety evaluation of nanotoxicity was addressed.

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Section: Discussionsupporting

confidence: 77%

“…showing that certain NPs with low toxic components, surface coatings and/or certain concentrations have no adverse effect to majority organs in mammals (Snima, Jayakumar, & Lakshmanan, 2014;Hauck, Anderson, Fischer, Newbigging, & Chan, 2010;Nurunnabi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Review of the effects of manufactured nanoparticles on mammalian target organs

Wu¹,

Tang

2017

J of Applied Toxicology

193

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“…Degree of hemolysis caused by drug loaded and blank nanoparticles was less than 5% (Snima et al, 2012). Snima et al (2014) also evaluated the O-carboxymethyl chitosan nanoparticles for pancreatic cancer therapy by means of in vitro (migration assay, clonogenic assay, cell cycle analysis and qRT-PCR analysis) and in vivo (biodistribution studies) studies. In cell migration study, the degrees of wound closure were 13.5%, 7% and 12% for MiaPaCa-2 cells treated with medium, blank-nanoparticles and metformin-loaded nanoparticles after 8 h of incubation, respectively.…”

Section: Metformin-loaded Microparticles and Nanoparticlesmentioning

confidence: 99%

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Çetin

Şahin

2015

Drug Delivery

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Context: Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on the proliferation of some cancer cells (e.g. prostate, breast, glioma cells) have been demonstrated in the cell culture studies. Development of novel formulation (e.g. microparticles, nanoparticles) strategies for metformin might be useful to improve its bioavailability, to reduce the dosing frequency, to decrease gastrointestinal side effects and toxicity and to be helpful for effective use of metformin in cancer treatment. Objective: The main aim of this review is to summarize metformin HCl-loaded micro-and nanoparticulate drug delivery systems. Method: The literature was rewieved with regard to the physicochemical, pharmacological properties of metformin, and also its mechanism of action in type 2 diabetes and cancer. In addition, micro-and nanoparticulate drug delivery systems developed for metformin were gathered from the literature and the results were discussed. Conclusion: Metformin is an oral antihyperglycemic agent and also has potential antitumorigenic effects. The repeated applications of high doses of metformin (as immediate release formulations) are needed for an effective treatment due to its low oral bioavailability and short biological half-life. Drug delivery systems are very useful systems to overcome the difficulties associated with conventional dosage forms of metformin and also for its effective use in cancer treatment.

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“…Snima et al worked on metformin, which is commonly used in the treatment of type‐2 diabetes. They chose this drug because metformin can influence cancer cells by two mechanisms: decreasing the cancer cell proliferation by decreasing the amounts of insulin and affecting intracellular signaling pathways .…”

Section: Introductionmentioning

confidence: 99%

“…These researchers investigated the effect of metformin encapsulated O‐Carboxymethyl chitosan NPs on PC cells (MiaPaCa‐2) and observed induced apoptosis and reduced colony formation in these cells. Snima and colleagues conducted both in vitro and in vivo trials and in addition to the effects of these NPs on gene expression of PC cells, they observed that these NPs leave no side effects on other organs in mice . Arya et al looked into the effects of curcumin on PC.…”

Section: Introductionmentioning

confidence: 99%

The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

2020

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Pancreatic cancer (PC) is one of the most lethal cancers and 12th most common cancer in the world. Due to the inaccessible anatomical position of the pancreas and asymptomatic early stages of this disease, PC has a high mortality rate. Therefore, providing reliable diagnostic and therapeutic tools are the keys to increase the PC survival rate. Nanotechnology is an inchoate field of science that previously scientists' tendency to enhance the efficacy of current preventive, diagnostic, and therapeutic methods has oriented them to build a bridge between this science and medicine. In the case of PC, nanotechnology suggests using drug delivery devices for a more effective and targeted therapy. Chitosan is a natural polymer that recently has attracted a lot of attention for being renewable, nontoxic, and bioabsorbable. In this article, we tend to look for the answer to this question: has nanotechnology been successful in using chitosan‐based nanoformulations as carriers for preventing more individuals from suffering or at least increasing the 5‐year survival of the PC patients?

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In Vitro and In Vivo Biological Evaluation of O-Carboxymethyl Chitosan Encapsulated Metformin Nanoparticles for Pancreatic Cancer Therapy

Abstract: The biocompatible O-CMC-metformin NPs with anticancer potential and capability for normal biodistribution can be beneficial for the treatment of pancreatic cancer.

Cited by 34 publications

References 38 publications

Review of the effects of manufactured nanoparticles on mammalian target organs

Review of the effects of manufactured nanoparticles on mammalian target organs

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

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