In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber

Gottenbos, B; Mei, Henny C. van der; Klatter, Flip A.; Nieuwenhuis, Paul; Busscher, Henk J.

doi:10.1016/s0142-9612(01)00263-0

Cited by 448 publications

(323 citation statements)

References 18 publications

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“…However, many coatings have been shown to be subject to microbial degradation (Kopteva et al, 2004). Coatings with added antimicrobials were shown to inhibit microbial degradation (Gottenbos et al, 2002;Park et al, 2004), for example, silver-based coatings were effective in the inhibition of biofilm formation (Liedberg and Lundeberg, 1989). Unfortunately, the fact that antimicrobials can dissolve from the coating into the environment raises serious concerns.…”

Section: Conventional Corrosion Inhibition and Prevention Methodsmentioning

confidence: 99%

The dual role of microbes in corrosion

2014

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Corrosion is the result of a series of chemical, physical and (micro) biological processes leading to the deterioration of materials such as steel and stone. It is a world-wide problem with great societal and economic consequences. Current corrosion control strategies based on chemically produced products are under increasing pressure of stringent environmental regulations. Furthermore, they are rather inefficient. Therefore, there is an urgent need for environmentally friendly and sustainable corrosion control strategies. The mechanisms of microbially influenced corrosion and microbially influenced corrosion inhibition are not completely understood, because they cannot be linked to a single biochemical reaction or specific microbial species or groups. Corrosion is influenced by the complex processes of different microorganisms performing different electrochemical reactions and secreting proteins and metabolites that can have secondary effects. Information on the identity and role of microbial communities that are related to corrosion and corrosion inhibition in different materials and in different environments is scarce. As some microorganisms are able to both cause and inhibit corrosion, we pay particular interest to their potential role as corrosion-controlling agents. We show interesting interfaces in which scientists from different disciplines such as microbiology, engineering and art conservation can collaborate to find solutions to the problems caused by corrosion.

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Section: Conventional Corrosion Inhibition and Prevention Methodsmentioning

confidence: 99%

The dual role of microbes in corrosion

2014

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“…Moreover, OMMT contains quaternary ammonium groups, which are the wellknown disinfectants. The biocidal action is implemented through increasing cell permeability and disrupting cell membranes [29][30][31]. Analogously, QCS could adsorb and immobilise bacteria via electrostatic and hydrophobic interactions.…”

Section: Antimicrobial Activity Of Qomamentioning

confidence: 99%

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

Chen

Cai³

et al. 2016

Journal of Experimental Nanoscience

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This work is aimed at developing a green antimicrobial coating. First, a green antimicrobial agent, quaternised chitosan (QCS)/organic montmorillonite (OMMT)/silver nanoparticles (Ag NPs) (QOMA) nanocomposite was fabricated through an environmental-friendly one-step approach. Morphological and structural characteristics of QOMA were investigated, and good antimicrobial activity was proved. QOMA was then incorporated into powder coating formulations to form a homogeneous coating on steel plates, which was studied by scanning electron images. Besides, the physical and mechanical properties as well as the antimicrobial performances of the coatings were discussed. The results showed that the addition of QOMA imparted good antimicrobial capacity to the powder coating, but did not affect its physical and mechanical properties. The coatings were able to effectively inactivate Gram-negative bacteria (Escherichia coli), Gram-positive bacteria (Staphylococcus aureus) and fungi (Aspergillus niger, Penicillium funiculosum, Chaetomium globasum, Paecilomyces varioti, Asp. terreus and Aureobasidium pullulans). Our findings demonstrate the possibilities of green antimicrobial coating containing QOMA for practical applications in medical devices, domestic appliances and other solid surfaces concerning bacterial infection and contamination.

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“…Quats exist endogenously within various tissues of the body (such as the central nervous system) and play a vital role in numerous biochemical pathways [1,2]. Additionally, they are frequently synthesized and routinely utilized in a variety of industries, with their uses ranging from personal care items such as antimicrobials [3][4][5] and antistatic agents [6,7] to herbicides [8][9][10][11] and pharmaceuticals [12,13].…”

Section: Introductionmentioning

confidence: 99%

A Novel Route to Recognizing Quaternary Ammonium Cations Using Electrospray Mass Spectrometry

Shackman

Ding

Bolgar

2014

J. Am. Soc. Mass Spectrom.

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Abstract. Characterizing and elucidating structures is a commonplace and necessary activity in the pharmaceutical industry with mass spectrometry and NMR being the primary tools for analysis. Although many functional groups are readily identifiable, quaternary ammonium cations have proven to be difficult to unequivocally identify using these techniques. Due to the lack of an N-H bond, quaternary ammonium groups can only be detected in the 1 H NMR spectra by weak signals generated from long-range 14 N-H coupling, which by themselves are inconclusive evidence of a quaternary ammonium functional group. Due to their low intensity, these signals are frequently not detected. Additionally, ions cannot be differentiated in a mass spectrum as an M + or [M + H] + ion without prior knowledge of the compound's structure. In order to utilize mass spectrometry as a tool for determining this functionality, ion cluster formation of quaternary ammonium cations and non-quaternary amines was studied using electrospray ionization. Several mobile phase modifiers were compared; however, the addition of small amounts of trifluoroacetic acid proved superior in producing characteristic and intense [M +2TFA] -clusters for compounds containing quaternary ammonium cations when using negative electrospray. By fragmenting this characteristic ion using CID, nearly all compounds studied could be unambiguously identified as containing a quaternary ammonium cation or a non-quaternary amine attributable to the presence (non-quaternary amine) or absence (quaternary ammonium cation) of the resulting [2TFA + H] -ion in the product spectra. This method of analysis provides a rapid, novel, and reliable technique for indicating the presence of quaternary ammonium cations in order to aid in structural elucidation.

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In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber

Cited by 448 publications

References 18 publications

The dual role of microbes in corrosion

The dual role of microbes in corrosion

Green antimicrobial coating based on quaternised chitosan/organic montmorillonite/Ag NPs nanocomposites

A Novel Route to Recognizing Quaternary Ammonium Cations Using Electrospray Mass Spectrometry

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