In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents

Kovala‐Demertzi, Dimitra; Papageorgiou, Athanassios; Papathanasis, Leuteris; Alexandratos, Alexandros; Dalezis, Panagiotis; Miller, John R.; Demertzis, Mavroudis A.

doi:10.1016/j.ejmech.2008.08.007

Cited by 67 publications

(31 citation statements)

References 17 publications

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“…The band due to v(CeSeC) of the thiophene ring remains unaltered in complexes (1ae5a and 1be5b), indicating non-participation of the thiophene ring in coordination. The azomethine stretching vibrations n(C]N), characteristic of a Schiff base are observed at 1582e1595 cm À1 [7]. The negative shift (30e78 cm À1 ) of the C]N band was observed in all complexes which exhibit the involvement of azomethine nitrogen upon complexation.…”

Section: Ir Spectral Studiesmentioning

confidence: 85%

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Karaküçük‐İyidoğan

Tasdemir

Oruç‐Emre

et al. 2011

European Journal of Medicinal Chemistry

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a b s t r a c tA series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UVeVis, IR, 1 H NMR, 13 C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.

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Section: Ir Spectral Studiesmentioning

confidence: 85%

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Karaküçük‐İyidoğan

Tasdemir

Oruç‐Emre

et al. 2011

European Journal of Medicinal Chemistry

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“…KovalaDemertzi et.al. have shown antitumor activity of platinum (II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine in different cell lines and in leukemia P388-bearing mice [47]. The thiosemicarbazones effectiveness were seen to be in different doses when were evaluated studies performed other cancer cell lines.…”

Section: Esi-mass Spectramentioning

confidence: 97%

Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

et al. 2009

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The S-methyl-thiosemicarbazones of the 2-hydroxy-R-benzaldehyde (R = H, 3-OH 3-OCH(3) or 4-OCH(3)) reacted with the corresponding aldehydes in the presence of FeCl(3) and NiCl(2). New ONNO chelates of iron(III) and nickel(II) with hydroxy- or methoxy-substituted N(1),N(4)-diarylidene-S-methyl-thiosemicarbazones were characterized by means of elemental analysis, conductivity and magnetic measurements, UV-Vis, IR and (1)H-NMR spectroscopies. Cytotoxic activities of the compounds were determined using K562 chronic myeloid leukemia and ECV304 human endothelial cell lines by MTT assay. It was determined that monochloro N(1)-4-methoxysalicylidene-N(4)-4-methoxysalicylidene-S-methyl-thiosemicarbazidato-iron(III) complex showed selective anti-leukemic effects in K562 cells while has no effect in ECV304 cells in the 0.53 microg/ml (IC(50)) concentrations. Also, some methoxy-substituted nickel(II) chelates exhibit high cytotoxic activity against both of these cell lines in low concentrations. Cytotoxicity data were evaluated depending on cell lines origin and position of the substituents on aromatic rings.

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“…The best known of these N,S-donor ligands are: thiosemicarbazones [5], thiohydrazides [6], aminoacids (cysteine, methionine) [7] and thiazole [8]. Beside them, there are many heterocyclic compounds that can act as N-donor ligands, such as pyrazoles, pyridazine, pyridines [9,10], piperidine, piperazine, picoline [11] and imidazoles [12]. Pyrazole-derived ligands have attracted scientists' attention over the last decades because of their interesting coordination chemistry, unusual structural features and remarkable physical and chemical properties [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, X-ray structures and cytotoxic activity of platinum(II), palladium(II) and copper(II) complexes with chelating ligands

Budzisz

Miernicka

Lorenz

et al. 2010

European Journal of Medicinal Chemistry

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Cited by 67 publications

References 17 publications

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

Synthesis, X-ray structures and cytotoxic activity of platinum(II), palladium(II) and copper(II) complexes with chelating ligands

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