2013
DOI: 10.1002/lsm.22212
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In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves

Abstract: The results of this study demonstrate that treatment parameters can be determined initially using in vitro models and then translated to in vivo research and clinical practice. Furthermore, this study establishes that infrared light with optimized parameters promotes accelerated nerve regeneration and improved functional recovery in a surgically repaired peripheral nerve.

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Cited by 81 publications
(37 citation statements)
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“…A wide variety of optical sources can be used to carry out these functions. 1,[13][14][15][16] For example, as indicated in Fig. 1, UV light from ArF or KrF lasers emitting at wavelengths of 193 and 249 nm, respectively, is strongly absorbed in the surface of a tissue and, thus, can be used for many surgical applications.…”
Section: Biophotonics Spectral Windowsmentioning
confidence: 99%
“…A wide variety of optical sources can be used to carry out these functions. 1,[13][14][15][16] For example, as indicated in Fig. 1, UV light from ArF or KrF lasers emitting at wavelengths of 193 and 249 nm, respectively, is strongly absorbed in the surface of a tissue and, thus, can be used for many surgical applications.…”
Section: Biophotonics Spectral Windowsmentioning
confidence: 99%
“…These obstacles to penetration lead to exponentially decaying intensities of light with depth. A study reporting the successful translation of in vitro results obtained in the Petri dish to the treatment of surgically repaired nerves in vivo found the optimal dose for nerve repair in vitro to be 97.5% less than that required when delivered on the surface of the skin (Anders et al, 2014).…”
Section: Dosingmentioning
confidence: 99%
“…The literature evidences the application of PBMT in other tissues or regions, such as bone [12,35], cartilage and orthopedic disorders [36], cells in vitro culture [37], Central Nervous System [38,39] and also in cases such as cerebral palsy in children [40]. In addition to PBMT, there are other physical agents that can be used in clinical practice as auxiliary methods in the treatment of tissue repair, such as lowintensity pulsed ultrasound [41].…”
Section: Other Applications Of Pbmtmentioning
confidence: 99%