In vitro and in vivo safety profile assessment of graphene oxide decorated with different concentrations of magnetite

Oliveira, Évelin Cogo de; Bruckmann, Franciele da Silva; Schopf, Patrícia Ferreira; Viana, Altevir Rossato; Mortari, Sérgio Roberto; Sagrillo, Michele Rorato; Vasconcellos, Noeli Julia Schüssler de; Fernandes, Liana da Silva; Rhoden, Cristiano Rodrigo Bohn

doi:10.1007/s11051-022-05529-w

Cited by 32 publications

(4 citation statements)

References 57 publications

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“…Diverse nanomaterials have been developed and improved to increase the performance in different applications. The unique properties and characteristics of nanomaterials (NMs) and nanoparticles (NPs) make them excellent agents for application in different areas, such as water remediation (126,127), medicine (128,129), development of sensors (130), drug delivery (131), and cancer treatment (132). Figure 4 shows some characteristics of nanoparticles.…”

Section: Nanoparticles Can Enhance Renal Cell Carcinoma Treatmentmentioning

confidence: 99%

An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies

DA SILVA PRADE,

DE SOUZA,

DA SILVA D’ΑVILA

et al. 2023

CDP

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Renal neoplasms are highlighted as one of the 10 most common types of cancer. Renal cell carcinoma (RCC) is the most common type of renal cancer, considered the seventh most common type of cancer in the Western world. The most frequently altered genes described as altered are VHL, PBRM1, SETD2, KDM5C, PTEN, BAP1, mTOR, TP53, TCEB1 (ELOC), SMARCA4, ARID1A, and PIK3CA. RCC therapies can be classified in three groups: monoclonal antibodies, tyrosine kinase inhibitors, and mTOR inhibitors. Besides, there are targeted agents to treat RCC. However, frequently patients present side effects and resistance. Even though many multidrug resistance mechanisms already have been reported to RCC, studies focused on revealing new biomarkers as well as more effective antitumor therapies with no or low side effects are very important. Some studies reported that natural products, such as honey, epigallocatechin-3-gallate (EGCG), curcumin, resveratrol, and englerin A showed antitumor activity against RCC. Moreover, nanoscience is another strategy to improve RCC treatment and reduce the side effects due to the improvement in pharmacokinetics and reduction of toxicities of chemotherapies. Taking this into account, we conducted a systemic review of recent research findings on RCC hallmarks, drug resistance, and adjuvant therapies. In conclusion, a range of studies reported that RCC is characterized by high incidence and increased mortality rates because of the development of resistance to standard therapies. Given the importance of improving RCC treatment and reducing adverse effects, nanoscience and natural products can be included in therapeutic strategies.

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Section: Nanoparticles Can Enhance Renal Cell Carcinoma Treatmentmentioning

confidence: 99%

An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies

DA SILVA PRADE,

DE SOUZA,

DA SILVA D’ΑVILA

et al. 2023

CDP

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“…This suggests the potential for developing environmentally safe nanocomposites that can be easily removed from the environment using magnetic fields and pose no acute toxicity to organisms like Artemia salina. [92]; however, given the contradictory findings in regard to their ecotoxic effects on D. magna [92][93][94][95], further research is needed to establish a clearer understanding of the impact of magnetic graphenic nanocomposites on the environment.…”

Section: Current Status Knowledge Gaps and Future Needsmentioning

confidence: 99%

Towards Understanding the Factors behind the Limited Integration of Multispecies Ecotoxicity Assessment in Environmental Risk Characterisation of Graphene-Family Materials—A Bibliometric Review

Fekete-Kertész,

László,

Molnár

2023

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Even though graphene-family materials (GFMs) hold great promise for various applications, there are still significant knowledge gaps in ecotoxicology and environmental risk assessment associated with their potential environmental impacts. Here, we provide a critical perspective on published ecotoxicity studies of GFMs based on meticulous bibliometric research. Based on the results of our review paper, in order to fill in the current critical knowledge gaps, the following issues are recommended for consideration: performing more studies on GFMs’ effects at environmentally relevant concentrations and more field and laboratory studies with marine and terrestrial organisms. It is also recommended to assess the ecotoxicity of GFMs in more environmentally relevant conditions, such as in trophic chain transfer studies and by multispecies exposure in micro- or mesocosms, as well as gaining insights into the interactive effects between GFMs and environmental pollutants. It was also revealed that despite their widespread detection in different environmental compartments the potential impacts of GFMs in complex test systems where hierarchical trophic organisation or trophic transfer studies are significantly under-represented. One of the main causes was identified as the difficulties in the physicochemical characterisation of GFMs in complex terrestrial test systems or aquatic micro- and mesocosm studies containing a sediment phase. The lack of tools for adequate characterisation of GFMs in these complex test systems may discourage researchers from conducting experiments under environmentally relevant test conditions. In the coming years, fundamental research about these complex test systems will continue to better understand the mechanism behind GFM toxicity affecting organisms in different environmental compartments and to ensure their safe and sustainable use in the future.

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“…In conducting the bioassay with Artemia salina, an adapted method described by previous researchers was employed [102]. In a glass container, a 1 L solution of artificial seawater was prepared according to the Dietrich and Kalle formula, which comprises distilled wa-ter, NaCl, MgCl 2 •6H 2 O, Na 2 SO 4 , CaCl 2 •2H 2 O, KCl, and the pH was adjusted to 9.0 with Na 2 CO 3 [103]. For hatching Artemia salina cysts, 500 mL of this artificial seawater was utilized, shielded with aluminum foil except for a small opening on the upper surface exposed to illumination from a 20 W lamp situated approximately 32 cm away.…”

Section: Toxicity Studiesmentioning

confidence: 99%

Cyanide Removal by ZnTiO3/TiO2/H2O2/UVB System: A Theoretical-Experimental Approach

Jaramillo-Fierro,

Ramón,

Valarezo

2023

IJMS

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Cyanide is a highly toxic substance present in wastewater from various industries. This study investigates the removal of cyanide species (CS) from aqueous solutions using the ZnTiO3/TiO2/H2O2/UVB system. ZnTiO3/TiO2 nanoparticles synthesized by the sol-gel method were characterized by powder X-ray diffractometry (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). The adsorption capacity of nanoparticles was tested by varying the pH of the solution, adsorbent concentration, and contact time. The adsorption of CS on ZnTiO3 and TiO2 surfaces was verified by Density Functional Theory (DFT) calculations. Photocatalytic experiments were achieved under UVB irradiation (λ = 310 nm). The response surface methodology (RSM) was used to optimize the CS removal efficiency. The detoxification effect was evaluated by acute toxicity tests with brine shrimp. The theoretical results show that the adsorption of CS is energetically more favorable on the ZnTiO3 surface than on the TiO2 surface. The experimental results show that the system consisting of ZnTiO3/TiO2 (200 mg L−1), H2O2 (0.1%), and UVB light removes 99% of CS from aqueous solutions after 60 min and reduces the mortality of nauplii in 90% after 90 min. This system was reused in five consecutive cycles with a total loss of efficiency of 30%.

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In vitro and in vivo safety profile assessment of graphene oxide decorated with different concentrations of magnetite

Cited by 32 publications

References 57 publications

An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies

An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies

Towards Understanding the Factors behind the Limited Integration of Multispecies Ecotoxicity Assessment in Environmental Risk Characterisation of Graphene-Family Materials—A Bibliometric Review

Cyanide Removal by ZnTiO3/TiO2/H2O2/UVB System: A Theoretical-Experimental Approach

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