In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

Yang, Yanmei; Shao, Qing; Deng, Renren; Wang, Chao; Teng, Xue; Cheng, Kai; Cheng, Zhen; Huang, Ling; Liu, Zhuang; Liu, Xiaogang; Xing, Bengang

doi:10.1002/anie.201107919

Cited by 446 publications

(289 citation statements)

References 92 publications

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“…In 2010 Carling et al [118] chromophore absorbs only in the UV (λ max = 282 nm), so it is light from the 1 D 2 ⇒ 3 H 6 emission of Tm 3+ at 290 nm that is necessary to trigger this photoreaction, hence the relatively high laser intensity needed. In a more directly biological application Yang et al [119] prepared NaYF 4 :Yb/Tm(20/0.2%)@NaYF 4 core : shell UCNPs (approx. 50 nm) coated with a thiolated SiO 2 layer which was conjugated to D-luciferin caged with a 1-(2-nitrophenyl)ethyl group.…”

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery (‘uncaging’) of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

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Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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“…In addition to photodynamic therapy, UCNPs have been used as energy donors in other photo-responsive drug release systems. 54 Liu and coworkers have reported the first in vivo demonstration of UCNP based photodynamic therapy. 55 UCNPs were synthesized by NaYF4 nanocrystals followed by PEG coating.…”

Section: Up Conversion Nanoparticlesmentioning

confidence: 99%

Optically Modulated Theranostic Nanoparticles

Valim¹,

Joshi²

2017

Frontiers in Nanobiomedical Research

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Nanoparticles are rapidly advancing as drug carriers for directing therapies in a spatio-temporally controlled manner. By virtue of their size ranging from tens to hundreds of nanometers, nanoparticles can preferentially trap in tumors and aberrant vascular interstitium, and can be targeted to specific molecular pathologies. Theranostic nanoparticles is an umbrella term designating the carriers, which combine both the drug/therapy transport with an imaging contrast. With suitable targeting, theranostic nanoparticles can be used for molecular imaging, and potentially for monitoring therapy response.1 To enhance therapy specificity to the disease site and reduce off-target effects, external and direct spatial-temporal control on therapy delivery is desirable. 2Multiple approaches for modulating theranostic nanoparticles have been reported, viz. magnetic fields, sonic energy, and optical radiation. Optical modulation in the range of visible and near infrared (NIR) wavelengths is a valuable tool for theranostic nanoparticle modulation because of its non-ionizing and safe nature, tissue penetration of multiple centimeters, easy multiplexing by including multiple interrogation wavelengths/ multiple fluorophores, low-cost, and advances in miniaturization of

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“…This frequency upconversion moves low energy light to higher energy light. Yang et al [52] demonstrated this concept by using caged D-luciferin [53]. They attached caged D-luciferin on the surface of the UCNPs (Tm/Tb co-doped NaYF4).…”

Section: Drug Release Through the Nir Up Conversion Systemsmentioning

confidence: 99%

Emerging Strategies for Controlling Drug Release by Using Visible/Near IR Light

Bio¹,

You²

2013

Med Chem

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Effective drug delivery systems require controlled drug release at the target cancer cell. While strategies for targeting tumors have been extensively studied, a better understanding of the necessary technology for controlling the spatiotemporal release of a drug is still needed. It has been established that the use of light can be a unique tool for controlling drug release. While UV light can be used for the release of biologically active, caged (deactivated) compounds, clinical application is restricted because of its limited ability to penetrate tissues as well as its cytotoxicity. Recently, the use of both tissue-penetrable visible and near IR have shown promise to overcome these limitations. In this short review, we introduce new smart strategies to convert such low energy light to a tissue-penetrable stimulus for both actively and remotely controlling drug release.

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In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

Cited by 446 publications

References 92 publications

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Optically Modulated Theranostic Nanoparticles

Emerging Strategies for Controlling Drug Release by Using Visible/Near IR Light

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