In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate‐Terminated Three‐Armed‐ and Hyperbranched Block Copolymeric Tissue Adhesives

Bochynska, Agnieszka; Hannink, Gerjon; Rongen, Jan J.; Grijpma, Dirk W.; Buma, P.

doi:10.1002/mabi.201700125

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…However, the systems described in the literature, as well as commercially available tissue adhesives do not bring the ideal answer to all the basic requirements, hence a lot of research still needs to be performed for PU adhesives to be used as surgical adhesive. Only a few systems are based on renewable biobased PU solutions compared to the large variety of fossil-based PU tissue adhesives recently developed [ [290] , [291] , [292] ].…”

Section: Biobased Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

244

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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Section: Biobased Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

244

173

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“…57 Methacrylate derivatives are used as bone glue in the literature, but their use is limited due to the lack of biodegradability. 58 In other bone adhesives, bioactive glass was about 20%, 59 isocyanate-terminated hyperbranched block copolymer was about %10, 60 and polylactide methacrylate/tricalcium phosphate was 20−40% 61 biodegradable. Therefore, our formulation is within the biodegradability limits of bone adhesives.…”

Section: Ex Vivo Compressive Strength Analysismentioning

confidence: 99%

Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure

Balcıoğlu

Noma

Ulu

et al. 2022

ACS Appl. Mater. Interfaces

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The use of wire cerclage after sternal closure is the standard method because of its rigidity and strength. Despite this, they have many disadvantages such as tissue trauma, operator-induced failures, and the risk of infection. To avoid complications during sternotomy and promote tissue regeneration, tissue adhesives should be used in post-surgical treatment. Here, we report a highly biocompatible, biomimetic, biodegradable, antibacterial, and UV-curable polyurethane-acrylate (PU-A) tissue adhesive for sternal closure as a supportive to wire cerclage. In the study, PU-As were synthesized with variable biocompatible monomers, such as silk sericin, polyethylene glycol, dopamine, and an aliphatic isocyanate 4,4′-methylenebis(cyclohexyl isocyanate). The highest adhesion strength was found to be 4322 kPa, and the ex vivo compressive test result was determined as 715 kPa. The adhesive was determined to be highly biocompatible (on L-929 cells), biodegradable, and antibacterial (on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus bacteria). Finally, after opening the sternum of rats, the adhesive was applied to bond the bones and cured with UV for 5 min. According to the results, there was no visible inflammation in the adhesive groups, while some animals had high inflammation in the cyanoacrylate and wire cerclage groups. These results indicate that the adhesive may be suitable for sternal fixation by preventing the disadvantages of the steel wires and promoting tissue healing.

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Application of adhesives in the treatment of cartilage repair

Feng,

Ang,

Guan

et al. 2024

Interdisciplinary Medicine

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From degeneration causing intervertebral disc issues to trauma‐induced meniscus tears, diverse factors can injure the different types of cartilage. This review highlights adhesives as a promising and rapidly implemented repair strategy. Compared to traditional techniques such as sutures and wires, adhesives offer several advantages. Importantly, they seamlessly connect with the injured tissue, deliver bioactive substances directly to the repair site, and potentially alleviate secondary problems like inflammation or degeneration. This review delves into the cutting‐edge advancements in adhesive technology, specifically focusing on their effectiveness in cartilage injury treatment and their underlying mechanisms. We begin by exploring the material characteristics of adhesives used in cartilage tissue, focusing on essential aspects like adhesion, biocompatibility, and degradability. Subsequently, we investigate the various types of adhesives currently employed in this context. Our discussion then moves to the unique role adhesives play in addressing different cartilage injuries. Finally, we acknowledge the challenges currently faced by this promising technology.

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In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate‐Terminated Three‐Armed‐ and Hyperbranched Block Copolymeric Tissue Adhesives

Cited by 4 publications

References 35 publications

Biobased polyurethanes for biomedical applications

Biobased polyurethanes for biomedical applications

Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure

Application of adhesives in the treatment of cartilage repair

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