In vitro and in vivo changes to PLGA/sirolimus coating on drug eluting stents

Xi, Tingfei; Gao, Runlin; Xu, Bo; Chen, Liang; Luo, Tong; Liu, Jing; Yan, Wei; Zhong, Shengping

doi:10.1016/j.biomaterials.2010.02.003

Cited by 59 publications

(43 citation statements)

References 29 publications

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“…The profiles of prepared DES need to be further confirmed in vivo, even though some researchers have suggested that sirolimus metabolism in vitro is similar to that in vivo [23] Drug release process in vitro may be actually different from that in vivo due to changes in environment and acid-base metabolism [23,24].…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Wang¹,

Chen²,

Lin³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Wang¹,

Chen²,

Lin³

et al. 2017

Trop. J. Pharm Res

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“…To further test our coatings surfaces, field emission scanning electron microscope (FESEM) combined with energy-dispersive X-ray spectroscopy (EDX) was used to detect the surface micro morphology (see fig. 3) and bulk chemical composition [33]. We can observe micro and nano-structures: the first are "cauliflower-like" and their average dimensions vary accordingly to the area tested (from 20 to 60 nm inside and from 50 to 120 nm outside), while the latter appear to be constant (around 6 nm) independently from side and zone.…”

Section: Stent Analysis Pre-implantationmentioning

confidence: 90%

Chemico-physical characterisation and in vivo biocompatibility assessment of DLC-coated coronary stents

et al. 2012

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Nanomaterials possess unique properties due to their particular surface chemistry, topography and roughness. These peculiarities can affect the type, concentration and bioactivity of proteins adsorbed, which may or not inhibit subsequent cellular adhesion and growth. Among all the nanomaterials, carbon allotropes in the last decades have achieved success thanks to their biocompatible behavior. In particular DLC thin films have been used as coating materials for several biomedical implants devices. In this work we have deeply characterized DLC coated coronary stents surface (XPS, AFM, FESEM) and bulk (TEM/EELS, Raman, EDX) properties in order to understand tissue growth on nanomaterials. In vivo studies, conducted on 24 pigs, have shown a complete endothelisation after 7 days, with no fibrin mesh and only rare monocytes scattered on the endothelial layer, while 30 and 180 days tests have shown a reduced inflammatory activation and a complete stabilization of the vessel healing and a minimal neointimal proliferation. Therefore, we can state that the DLC coating tested here appeared to be a promising material for rapid endothelisation of intravascular stent devices.5.

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“…As PLGA undergoes bulk erosion, the coating experiences mass loss while the integral structure is maintained. The coating structure has been reported to maintain integrity during the entire degradation period, until much later time after complete elution of the loaded drug [10]. Therefore, the coating domain can be considered as intact for the time span of interest.…”

Section: Model Developmentmentioning

confidence: 99%

“…Among the vari ous research directions, the utilization of biodegradable polymer coatings in place of the biodurable coatings has been proposed [8,9]. In particular, biocompatible PLGA, and allows tunable drug release rates based on different polymer molecular weights, has received a high amount of interest in ongoing drug-eluting stents research [10][11][12][13][14], While most studies were carried out for exami nation of release under in vitro conditions, further evaluation of PLGA stent coating for in vivo evaluations of implanted stents are necessary and are typically significantly more costly.…”

mentioning

confidence: 99%

Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

Zhu

Braatz

2014

Journal of Biomechanical Engineering

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Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery.

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In vitro and in vivo changes to PLGA/sirolimus coating on drug eluting stents

Cited by 59 publications

References 29 publications

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Chemico-physical characterisation and in vivo biocompatibility assessment of DLC-coated coronary stents

Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

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