In vitro and in vivo evaluation of polyhydroxybutyrate and of polyhydroxybutyrate reinforced with hydroxyapatite

Doyle, Christina; Tanner, Elizabeth; Bonfield, W.

doi:10.1016/0142-9612(91)90072-i

Cited by 312 publications

(180 citation statements)

References 2 publications

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“…Nevertheless, biocomposites of these polymers with calcium orthophosphates showed a good biocompatibility both in vitro and in vivo [94,[340][341][342][343][344][345]. Both bioactivity and mechanical properties of these biocomposites can be tailored by varying the volume percentage of calcium orthophosphates.…”

Section: Apatite-based Biocompositesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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Section: Apatite-based Biocompositesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…Other works also presented increase of approximately 30% of the mechanical properties by addition of HA particles [14,15]; in both cases the enhancement of the mechanical properties was related to the utilization of nanosized particles and the good distribution in the matrix. Doyle et al [7] reported a reduction of the mechanical strength of PHB/HA composites by addition of HA particles. The composites were formed via injection molding of PHB and PHB/HA mixtures at 170 °C.…”

Section: Resultsmentioning

confidence: 99%

“…PHB is of particular interest for bone tissue application as it was demonstrated to produce a consistent favorable bone tissue adaptation response with no evidence of an undesirable chronic inflammatory response after implantation periods of up to 12 months. Bone is formed close to the material and subsequently becomes highly organized, with up to 80% of the implant surface lying in direct apposition to new bone [7]. PHB-based biomaterials have also been related to be piezoelectric and promote bone growth in vivo [8,9].…”

Section: Introductionmentioning

confidence: 99%

Production of polyhydroxybutyrate and hydroxyapatite (PHB/HA) composites for use as biomaterial

et al. 2017

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The composite materials using polyhydroxybutyrate as matrix and hydroxyapatite as reinforcement (PHB/HA) were produced by molding, using pressing at 100 MPa and 165 °C for 30 min. The amount of filler was varied from 0 to 20 wt% to evaluate the effect of the HA particles on mechanical properties and the bioactivity of the composites. The increase of the HA amount reduced the compressive strength of the composites nearly 20% while bending strength reduced nearly 30%. However, the bioactivity after 14 days immersion in SBF was improved with the increase of HA amount, with formation of apatite layer on the surface of the PHB/HA composite. Keywords: polyhydroxybutyrate, hydroxyapatite, composite, biomaterials. Resumo Materiais compósitos com matriz de poli-hidroxibutirato e material de reforço de hidroxiapatita (PHB

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“…Essa hipótese foi confirmada à histologia como descrito a seguir. Além disso, após a descalcificação, o material ainda era rígido, o que dificultou a microtomia, permitindo a atuação das forças de arrasto desse procedimento no PHB em degradação (DOYLE et al, 1991). A contração dos tecidos durante o processamento histológico (DENISSEN & GROOT, 1990) também pode ter atuado no PHB em degradação na interface, contribuindo para a separação.…”

Section: Resultsunclassified

“…Aos 45 e 90 dias, não era possível delimitar 37,5 e 31,25% das margens dos quadrantes, respectivamente, onde não mais existia o halo menos radiopaco que o osso próximo ao defeito e os defeitos diminuíram de tamanho. Portanto, foi constatada a neoformação óssea nas bordas do compósito, reforçando a biocompatibilidade e indicando a osseointegração (DOYLE et al, 1991;KNOWLES et al, 1992;LUKLINSKA & BONFIELD, 1997).…”

Section: Resultsunclassified