In-vitro and in-vivo transdermal iontophoretic delivery of tramadol, a centrally acting analgesic

Takasuga, Shinri; Yamamoto, Rie; Mafune, Shoichi; Sutoh, Chiyo; Kominami, Katsuya; Yoshida, Yoshimasa; Ito, Masao; Kinoshita, Mine

doi:10.1111/j.2042-7158.2011.01355.x

Cited by 17 publications

(7 citation statements)

References 56 publications

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“…This can be achieved using eutectic mixtures of local anesthetics, controlled heat, magnetophoresis, iontophoresis,[4647] electroporation, or sonophoresis. [48] Using iontophoresis dermal anesthesia with lignocaine can be achieved. [4950] The effect can be enhanced by adding adrenaline.…”

Section: Controlled Release Drug Therapymentioning

confidence: 99%

Newer drug delivery systems in anesthesia

Dave

Shriyan

Gujjar

2017

J Anaesthesiol Clin Pharmacol

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Section: Controlled Release Drug Therapymentioning

confidence: 99%

Newer drug delivery systems in anesthesia

Dave

Shriyan

Gujjar

2017

J Anaesthesiol Clin Pharmacol

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“…vertical) Franz cells or horizontal cells, which allow membrane permeation to be investigated, e.g. in porcine skin . In vivo evaluation of the pharmacokinetics of topically administered drugs is more complex.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Trials and tribulations of skin iontophoresis in therapeutics

Roustit

Blaise

Cracowski

2013

Brit J Clinical Pharma

100

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Iontophoresis is a method of non-invasive transdermal drug delivery based on the transfer of charged molecules using a low-intensity electric current. Both local and systemic administration are possible; however, the skin pharmacokinetics of iontophoretically delivered drugs is complex and difficult to anticipate. The unquestionable theoretical advantages of the technique make it attractive in several potential applications. After a brief review of the factors influencing iontophoresis, we detail the current applications of iontophoresis in therapeutics and the main potential applications under investigation, including systemic and topical drugs and focusing on the treatment of scleroderma-related ulcerations. Finally, we address the issue of safety, which could be a limitation to the routine clinical use of iontophoresis.

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“…In recent years, tramadol has been researched for the treatment of domestic feline pain. Tramadol is a synthetic opioid that exerts analgesic effects by binding to µ-opioid receptors as well as inhibiting neuronal reuptake of norepinephrine and serotonin [4]. Previous studies have shown that tramadol can be used alone or in combination with NSAIDs for the treatment of mild to moderate pain in domestic felines [5,6].…”

Section: Introductionmentioning

confidence: 99%

In vitro characterization of the percutaneous absorption of tramadol into inner ear domestic feline skin using the Franz skin finite dose model

Bassani¹,

Banov²,

Simmons³

et al. 2015

Vet Med Anim Sci

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Pain, whether it is acute or chronic, can induce stress and reduce overall quality of life for domestic felines. Tramadol, a synthetic opioid that exerts analgesic effects by binding to µ-opioid receptors as well as inhibiting neuronal reuptake of norepinephrine and serotonin, can be used alone or in combination with NSAIDs for the treatment of domestic feline pain. Tramadol can be incorporated into transdermal bases such as PLO or Lipoderm for transdermal delivery. The purpose of this study is to characterize the percutaneous absorption of two tramadol formulations (Tramadol 100 mg/g in PLO and Tramadol 100 mg/g in Lipoderm), when applied to the inner ear of domestic feline skin, in vitro, using the Franz skin finite dose model. A variable finite dose (e.g., 25 µg/cm 2) of each formulation was applied to skin sections from two donors and cultured within Franz diffusion cells for 48 hr. Tramadol total absorption, rate of absorption, surface wash, and skin content were quantified using HPLC analysis. Results show that both PLO and Lipoderm were capable of facilitating the percutaneous absorption of tramadol across ex-vivo domestic feline inner ear skin. However, tramadol content within surface wash (3.65%±0.14) was lower for the Lipoderm formulation, which potentially correlates to the higher total absorption (100.40%±3.24) of tramadol when in Lipoderm. Although the rise to peak rate of absorption was approximately 2.5 hr for both formulations, the decline in rate was steadier and more predictable for tramadol in Lipoderm than in PLO. Results of this study can help practitioners and pharmacists predict the in vivo percutaneous absorption of tramadol in domestic felines. The prediction can then guide them in selecting the most favorable transdermal base when prescribing and compounding with tramadol for domestic feline use.

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In-vitro and in-vivo transdermal iontophoretic delivery of tramadol, a centrally acting analgesic

Abstract: The present study reveals that anodal iontophoresis provides current-controlled transdermal delivery of tramadol without significant interspecies differences, and enables the delivery of therapeutic amounts of tramadol.

Cited by 17 publications

References 56 publications

Newer drug delivery systems in anesthesia

Newer drug delivery systems in anesthesia

Trials and tribulations of skin iontophoresis in therapeutics

In vitro characterization of the percutaneous absorption of tramadol into inner ear domestic feline skin using the Franz skin finite dose model

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