In vitro and in vivo antioxidative and radioprotective capacities of polysaccharide isolated from <i>Mesona Blumes</i> gum

Feng, Tao; Sang, Miao; Zhuang, Haining; Xu, Zhimin

doi:10.1002/star.201700056

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…In addition to its antioxidant and antitumor activities, fucoidan can exert radioprotective effects in a dose-dependent manner [94,194]. In addition, plant polysaccharides, such as aloe polysaccharide [189], Mesona blume polysaccharide [195], cereal β-glucan [196], Heliantnus tuberosus L. polysaccharide, Laminaria japonica polysaccharide, Alga polysaccharide, Haberlea rhodopensis polysaccharide, purple sweet potato polysaccharide, soybean meal polysaccharide, pectin polysaccharide, Panax ginseng polysaccharide, and Tinospora cordifolia root polysaccharide, have demonstrated radioprotective effects.…”

Section: Plant Polysaccharidesmentioning

confidence: 99%

Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities

Zhang

Huang

Zheng

et al. 2023

Cancers

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Radiotherapy is an important cancer treatment. However, in addition to killing tumor cells, radiotherapy causes damage to the surrounding cells and is toxic to normal tissues. Therefore, an effective radioprotective agent that prevents the deleterious effects of ionizing radiation is required. Numerous synthetic substances have been shown to have clear radioprotective effects. However, most of these have not been translated for use in clinical applications due to their high toxicity and side effects. Many medicinal plants have been shown to exhibit various biological activities, including antioxidant, anti-inflammatory, and anticancer activities. In recent years, new agents obtained from natural products have been investigated by radioprotection researchers, due to their abundance of sources, high efficiency, and low toxicity. In this review, we summarize the mechanisms underlying the radioprotective effects of natural products, including ROS scavenging, promotion of DNA damage repair, anti-inflammatory effects, and the inhibition of cell death signaling pathways. In addition, we systematically review natural products with radioprotective properties, including polyphenols, polysaccharides, alkaloids, and saponins. Specifically, we discuss the polyphenols apigenin, genistein, epigallocatechin gallate, quercetin, resveratrol, and curcumin; the polysaccharides astragalus, schisandra, and Hohenbuehelia serotina; the saponins ginsenosides and acanthopanax senticosus; and the alkaloids matrine, ligustrazine, and β-carboline. However, further optimization through structural modification, improved extraction and purification methods, and clinical trials are needed before clinical translation. With a deeper understanding of the radioprotective mechanisms involved and the development of high-throughput screening methods, natural products could become promising novel radioprotective agents.

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Section: Plant Polysaccharidesmentioning

confidence: 99%

Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities

Zhang

Huang

Zheng

et al. 2023

Cancers

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The Radioprotective Effect of Polyphenols From Pinecones of Pinus koraiensis and Their Synergistic Effect With Auricularia auricula‐judae (Bull.) J. Schröt Polysaccharides

et al. 2018

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The objectives of this work are to investigate the protective effect of Polyphenols from pinecones of Pinus koraiensis (PPPK) on damage caused by radiation in mice, and to test for its potential synergism with Auricularia auricula‐judae (Bull.) J. Schröt Polysaccharides (AAP). Male mice are administered for 30 days prior to radiation, and the combination index (CI) is used for the synergistic effect analysis. The results show that PPPK exhibited significant radioprotective effects compared with radiation group (P < 0.01); PPPK in combination with AAP had higher anti‐radiation effects, as evident by improved white blood cells (P < 0.01), organ indexes (P < 0.05 or 0.01), splenic lymphocytes proliferation activity (P < 0.01), bone marrow DNA content (P < 0.01), and monocyte phagocytic activity (P < 0.05), relative to other groups; the combination also reduced bone marrow micronucleus rate (P < 0.01) and chromosome distortion rate (P < 0.01). These data for the first time demonstrated the radioprotective effect of PPPK and its synergistic effect with AAP.

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Cell damage repair mechanism in a desert green algae Chlorella sp. against UV-B radiation

Wang

et al. 2022

Ecotoxicology and Environmental Safety

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In vitro and in vivo antioxidative and radioprotective capacities of polysaccharide isolated from Mesona Blumes gum

Cited by 7 publications

References 31 publications

Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities

Exploring Natural Products as Radioprotective Agents for Cancer Therapy: Mechanisms, Challenges, and Opportunities

The Radioprotective Effect of Polyphenols From Pinecones of Pinus koraiensis and Their Synergistic Effect With Auricularia auricula‐judae (Bull.) J. Schröt Polysaccharides

Cell damage repair mechanism in a desert green algae Chlorella sp. against UV-B radiation

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