In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

Abstract

Nowadays, the most advanced skin anti-aging treatments are addressed to restore the extracellular matrix (ECM) homeostasis. ECM is considered the main player not only as physical support of the tegument but also at the biochemical level, thanks to its capacity to exchange nutrients, water, cellular mediators, and growth factors within and between cells. This study aimed to evaluate the in vitro and in vivo efficacy and aesthetic performance of a brand-new intracutaneous filler. The latter is based on novel concepts: besides filling it exerts a homeostatic balance of nutrients able to delay the skin aging process by sustaining physiological rejuvenation of the tissue and in the surrounding injection/implantation area. The brand-new intracutaneous filler was tested for in vitro capacity to stimulate extracellular matrix components production. Therefore, a single session for injection of the product under study was performed by a specialized dermatologist, using the bolus technique on the zygomatic protuberance of 20 healthy female subjects with midface volume loss, caused by aging. Results confirmed the important and long-term volumizing, anti-wrinkle, the hydrating activity of this product after one single injection session. The biological outcomes also support product effectiveness in skin structure restoration.

Protocolo de biorrevitalización con hialuronato, aminoácidos, polifenoles y antioxidantes

“…La inyección de un complejo de hialuronato sódico, aminoácidos y antioxidantes permite una adecuada estimulación del colágeno dérmico que, además, favorecerá la hidratación que se verá reflejada como un aumento de la luminosidad y tersura [11][12][13]. Es un tratamiento idóneo en ambos sexos, sin limitaciones de fototipo, estaciones del año o clima y con alta demanda.…”

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

“…Indeed, two injectable fillers, consisting of collagen, hyaluronic acid and carboxymethylcellulose, are now commercially available. In particular, Fillagen ® (Monodermà, Milan, Italy), made with recombinant polypeptide of collagen α1-chain from silkworm [ 178 ], and Karisma ® (Taumed, Rome, Italy), made with unspecified recombinant collagen were proposed. More recently a photocurable collagen-based regenerative dermal and soft tissues filler was developed by CollPlant Biotechnologies Ltd (Rehovot, Israel, , accessed on 14 February 2023), comprising a recombinant type I collagen from tobacco plant (not currently commercially available).…”

Multi-Functional Collagen-Based Biomaterials for Biomedical Applications

“…Indeed, two injectable fillers, consisting of collagen, hyaluronic acid and carboxymethylcellulose, are now commercially available. In particular, Fillagen ® (Monodermà, Milan, Italy), made with recombinant polypeptide of collagen α1-chain from silkworm [178], and Karisma ® (Taumed, Rome, Italy), made with unspecified recombinant collagen were proposed. More recently a photocurable collagen-based regenerative dermal and soft tissues filler was developed by CollPlant Biotechnologies Ltd (Rehovot, Israel, www.collplant.com, accessed on 14 February 2023), comprising a recombinant type I collagen from tobacco plant (not currently commercially available).…”