In-vitro anthelmintic activity of seeds of Zanthoxylum armatum DC. against Pheretima Posthuma

Mehta, Dinesh Kumar; Bhandari, Anil; Das, Rina

doi:10.4103/0973-8258.97116

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…[12] According to the World Health Organization a staggering two billion people harbor parasitic worm infections. [3] Poorer personal and environmental hygienic conditions, inadequate sanitary facilities, and lack of supply of pure water, coupled with poverty and illiteracy, are the major fundamental factors responsible for the spreading of helminthiasis in developing countries.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Poorer personal and environmental hygienic conditions, inadequate sanitary facilities, and lack of supply of pure water, coupled with poverty and illiteracy, are the major fundamental factors responsible for the spreading of helminthiasis in developing countries. [1] Helminth infections also contribute to the prevalence of undernourishment, anemia, eosinophilia, and pneumonia. Although several drugs are available for the treatment of parasitic diseases, yet helminthiasis is principally responsible for the ruthless morbidity affecting the population in endemic areas.…”

Section: Introductionmentioning

confidence: 99%

“…Gastrointestinal helminth infections have become resistant to the currently available synthetic anthelmintic drugs, which cause the foremost problem in the treatment of helminths diseases. [145] Hence, the demand for natural anthelmintics is increasing.…”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves

Sen¹,

De²,

Devanna³

et al. 2012

Ancient Sci Life

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Leea asiatica, a folk medicinal plant of India, is used in the treatment of worm infection and other oxidative stress-related disorders, traditionally. In the present study, the in vitro anthelmintic and in vitro antioxidant activity of different fractions of the methanol extract from the Leea asiatica leaves were evaluated. The fraction displayed significant anthelmintic activity against Indian adult earthworms (Pheretima posthuma). The ethyl acetate fraction showed a better paralysis activity (13.99 ± 0.59), while the methanol fraction showed a better death time (63.76 ± 0.73 minutes), when compared with other fractions, at a dose of 50 mg/ml concentration. The anthelmintic activity of methanol and the ethyl acetate fraction were almost similar and comparable to the standard drug, piperazine citrate. The petroleum ether fraction did not produce a potent anthelmintic effect compared to the standard. The in vitro antioxidant activity was evaluated by using the diphenyl-picrylhydrazyl (DPPH) radical scavenging assay, nitric oxide radical scavenging assay, lipid peroxidation assay, and the ferric thiocyanate method. The ethyl acetate fraction showed better antioxidant activity in all tested methods. The IC50 value of the ethyl acetate fraction in the DPPH radical, nitric oxide radical scavenging assay, and lipid peroxidation assay were 9.5, 13.0, and 57.0 μg/ml, respectively. The fractions significantly (P < 0.05) inhibited the peroxidation of linoleic acid. The results confirmed the folk use of Leea asiatica in warm infection and the plant could be viewed as a potential source of natural anthelmintic and antioxidant compound.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves

Sen¹,

De²,

Devanna³

et al. 2012

Ancient Sci Life

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show abstract

“…[314] The different extract concentrations (10, 25, 50, and 75 mg/ml) were obtained by dissolving 100 mg, 250 mg, 500 mg, and 750 mg/ml of crude extract in 1 ml of tween 80 and adjusted volume up to 10 ml with normal saline solution. Albendazole was used as a standard drug for this study.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract

Jamkhande¹,

Barde²

2014

Ancient Sci Life

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Background:Worm infection and associated complications are severe problems that afflict a large population worldwide. Failure of synthetic drugs in worm infections because of drug resistance has made alternative drug therapy desirable. Cordia dichotoma (Forst.) is an ethnomedicinal plant which is rich in several secondary metabolites. Traditionally, the plant has been claimed to have high medicinal properties including antimicrobial activity and cytotoxicity.Materials and Methods:The study begun with an aim to explore plant-based natural anthelmintic agents against Pheretima posthuma, an Indian earthworm. Methanol extract of the drug was obtained by successive soxhlet extraction. The extract was tested for different phytochemicals. Worms were exposed to 10 mg/ml, 25 mg/ml, 50 mg/ml, and 75 mg/ml concentrations of extract and standard drug, albendazole. A software-based tool, prediction of activity spectra for substances was used to estimate anthelmintic efficacy of plant metabolites.Result:The phytochemical analysis revealed presence of alkaloids, tannins, glycosides, saponins, flavonoids, and phenols. The extract showed dose-dependent effects, affecting worm motility, viability, and mortality. It was also found that the biological activity spectrum of the plant phytoconstituents such as octacosanol, lupeol, caffeic acid, and hentricontanol were >0.5 (probable activity > 0.5).Conclusion:The findings of the present work suggest that the extract of C. dichotoma significantly interferes with motility pattern of P. posthuma. The paralysis and mortality of P. posthuma might be due to the combined effects different phytoconstituents. The extract of C. dichotoma promises natural sources to control worm infection.

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“…The Aqueous Citation: Barua extract of the leaves showed antiprotozoal effect on Giardia Lamblia, Plasmodium berghei. 44…”

Section: Anthelmintic Activitymentioning

confidence: 99%

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

Barua

Yasmin

Elancheran

2018

MOJBB

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Traditionally it is used by the Bhotiya communities for food, medicines and exchange in the Uttaranchal, Himalaya of India. The Zanthoxylum armatum fruit is used by the Bhotiyas of Pithoragarh district of Kumaon region while those of the Kamoli district of Garhwal have developed the collection and trade of Z. armatum sticks to pilgrims visiting the shrines of Badrinath, Kedarnath, Gangotri and Yamunotri. 2 The fruits, bark and leaves are used as spice, in the Indian medicine system. Definition Zanthoxylum armatum known as winged prickly ash is a species of plant in the Rutaceae family. It is an aromatic deciduous, spiny shrub growing to 3.5 meters in height, endemic to China, Japan, Korea and India. Zanthoxylum armatum is a wild plant and mostly used as a condiment and medicine and have other medicinal properties.

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In-vitro anthelmintic activity of seeds of Zanthoxylum armatum DC. against Pheretima Posthuma

Cited by 14 publications

References 8 publications

Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves

Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves

Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

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