In vitro anti-allergic activities of a newly concocted traditional Chinese medicine—The wheeze-relief formula

Lee, S.K.W.; Wong, Chun Kwok; Sung, Rita Y T; Leung, Ting Fan; Fung, Kwok‐Pui; Leung, Ping Chung; Lam, Christopher Wai Kei

doi:10.1016/j.jep.2005.08.031

Cited by 14 publications

(15 citation statements)

References 25 publications

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“…Recent studies have reported on the anti-allergic mechanism induced by this herb in both in vitro and in vivo models Kim et al, 2004;Lee et al, 2005;Li et al, 2005). It has been reported that HC has inhibitory effects on anaphylactic reaction and mast cell activation (Li et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration

Kim

et al. 2007

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration

Kim

et al. 2007

Journal of Ethnopharmacology

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“…Some recipes and validation of claimed properties of herbal mixtures have been reported in China, Japan, Cuba and Syria (Cano and Volpato, 2004;Carmona et al, 2005;Lee et al, 2006). In China, there exists a number of government supported groups responsible for quality and safety of traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

In vitro pharmacological effects of manufactured herbal concoctions used in KwaZulu-Natal South Africa

Ndhlala

Stafford

Finnie

et al. 2009

Journal of Ethnopharmacology

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“…They have been used for the relief and prophylactic treatment of asthmatic symptoms for many years. While research on β 2 -AR agonists has extensively focused on chemosynthetic drugs, TCM agents are also effective in asthma treatments, and research focused on identifying the responsible agents is warranted [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects

et al. 2009

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Aim:To investigate the anti-asthmatic mechanisms of the traditional Chinese medicine Pericarpium citri reticulatae (PCR). Methods: The alkaloid section (AS) of PCR was extracted using an ion exchange resin, separated, and purified into different fractions by semi-preparative HPLC. These fractions were screened for beta2-adrenergic receptor (β 2 AR) agonistic activity using rat β 2 AR-transfected CHO-CRE-EGFP cells. AS and its isolated components were characterized by ultra-performance liquid chromatography/quadrupole time-of-flight MS (UPLC/Q-Tof MS) and were evaluated for their spasmolytic and antitussive activities both in vitro and in vivo in a guinea pig model. Results: We demonstrated that the AS component responsible for activating β 2 AR signaling was synephrine. Both AS and synephrine showed significant spasmolytic effects on acetylcholine chloride (ACh)-induced contractions in isolated guinea pig trachea, and they protected against histamine-induced experimental asthma by prolonging the latent period. We further identified stachydrine as the antitussive component that could significantly reduce citric acid-induced coughing. The combination of these two bioactive compounds had a more potent spasmolytic activity in comparison with the single use of synephrine or stachydrine. Conclusion: We conclude that synephrine and stachydrine are the key components of AS that mediate asthma relief due to their synergism when used in combination.

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In vitro anti-allergic activities of a newly concocted traditional Chinese medicine—The wheeze-relief formula

Cited by 14 publications

References 25 publications

The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration

The inhibitory effect of Houttuynia cordata extract on stem cell factor-induced HMC-1 cell migration

In vitro pharmacological effects of manufactured herbal concoctions used in KwaZulu-Natal South Africa

Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects

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