In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases

Li, Yang; Xu, Chen; Zhang, Qiang; Liu, Jun-Yan; Tan, Ren Xiang

doi:10.1016/j.jep.2005.01.020

Cited by 208 publications

(116 citation statements)

References 19 publications

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“…The findings indicated that a significant number of species examined in the study (both aqueous and ethanolic extracts) have inhibitory effects on H. pylori [38].…”

Section: Discussionmentioning

confidence: 84%

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Abachi¹

2013

IOSR-JDMS

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“…The findings indicated that a significant number of species examined in the study (both aqueous and ethanolic extracts) have inhibitory effects on H. pylori [38].…”

Section: Discussionmentioning

confidence: 84%

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Abachi¹

2013

IOSR-JDMS

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“…This is in accordance with previous studies that showed physiological effects of the active ingredients in the modified Ban Xia Xie Xin decoction. In China, Ban Xia Xie Xin decoction is used for FD, and some of the active ingredients in the modified Ban Xia Xie Xin decoction have been shown to reinforce the protective function of the mucosa, regulate gastrointestinal function, and induce anti-inflammatory action against H. pylori [16][17][18][19][20]. However, herbal preparations are complex and contain a number of active ingredients that may work together.…”

Section: Discussionmentioning

confidence: 99%

“…We added related herbal medicines (Cortex Magnoliae officinalis, Medicated Leaven, Ark Shell) to that recipe to identify the formula of "modified Ban Xia Xie Xin decoction" that had a satisfactory clinical effect. Moreover, previous studies have shown that the active ingredients in the modified Ban Xia Xie Xin decoction can reinforce the protective function of the mucosa, regulate gastrointestinal function, and induce anti-inflammatory action against Helicobacter pylori [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial

Zhao¹,

Zhang²,

Wang³

et al. 2013

Deutsche Zeitschrift für Akupunktur

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“…Diverse biological activities of species from this family have been demonstrated, such as anti-ulcer (Li, 2005), giardicidal (Amaral, 2006), acetylcholinesterase inhibition , antiplasmodial (Dolabela, 2008), and trypanocidal activity (Mafezoli, 2000). Limonoids and flavonoids are among the active chemical components of Rutaceae species already reported (Nakagawa, 2006).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory and antibacterial activities of extracts from Rutaceae species

Costa¹,

Juíz²,

Pedro³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade imunomoduladora e antibacteriana de extratos de espécies da família Rutaceae." A família Rutaceae apresenta espécies vegetais muito bem distribuídas no Semi-Árido Brasileiro e comumente usadas em medicina popular. Espécies dessa família tem diversas atividades biológicas descritas na literatura. Neste trabalho, atividades imunomoduladora e bactericida são descritas para o extrato acetato de etila e clorofórmico de três espécies da família (Esenbeckia grandiflora Mart., Pilocarpus spicatus A.St.-Hil. e Galipea simplicifolia Schult.). Todas as amostras foram inicialmente avaliadas quanto à sua citotoxicidade, com objetivo de determinar a LC50. O potencial imunomodulador foi avaliado em culturas de esplenócitos murinos estimulados ou não com concanavalina A e também em reação mista linfocitária (RML),usando também esplenócitos de camundongos BALB/c (H-2 d ) imunizados com esplenócitos de camundongos C57Bl/6 (H-2 b ). Quatro amostras tiveram os mais elevados valores percentuais de inibição da proliferação de linfócitos ativados pela concanavalina A e foram avaliados em RML. A atividade antibacteriana dos extratos foi também avaliada e a concentração mínima inibitória (CMI) para duas amostras ativas foi de 1.0 e 5.0 mg/mL, respectivamente para as espécies Esenbeckia grandiflora Mart. and Galipea simplicifolia Schult. Assim, os dados aqui apresentados reforçam informações da literatura científica relacionados à atividade biológica para muitas espécies da família Rutaceae e incentivam outros estudos com estas visando descobrir substâncias ativas, potenciais candidatas a novos fármacos.Unitermos: Atividade imunomoduladora, Rutaceae, atividade antibacteriana. ABSTRACT:Rutaceae is a taxon with species very well distributed in Brazilian semi-arid area, commonly used in folk medicine. Species from this genus have diverse biological activity described in literature. In this work, immunomodulatory and bactericidal activity are described for chloroform and ethyl acetate extracts of three of them (Esenbeckia grandiflora Mart., Pilocarpus spicatus A.St.-Hil. and Galipea simplicifolia Schult.). Initially all the samples had their cytotoxicity evaluated, aiming to determine the LC50. The immunomodulatory potential was evaluated in cultures of murine splenocytes stimulated or not with concanavalin A and in a mixed lymphocyte reaction (MLR) using splenocytes from BALB/c (H-2 d ) mice immunized with splenocytes from C57Bl/6 (H-2 b ) mice. Four samples had higher values of lymphoproliferation inhibition in concanavalin A-stimulated cultures and were evaluated in MLR. The antibacterial activity of extracts was also evaluated and the minimal inhibitory concentrations (MIC) for two active samples were 1.0 and 5.0 mg/ml for extracts from Esenbeckia grandiflora Mart. and Galipea simplicifolia Schult., respectively. Thus, our results reinforce data of literature relating biological activity for many species of the Rutaceae family and encourage studies with these species aiming to discover active compounds, candidates to n...

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In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases

Cited by 208 publications

References 19 publications

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori

Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial

Immunomodulatory and antibacterial activities of extracts from Rutaceae species

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