In Vitro Anti-HIV Activity of Biflavonoids Isolated fromRhus succedaneaandGarcinia multiflora

Abstract

Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7"-O-beta-glucoside (13), and GB-2a (14) isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity. The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 microM. Compounds 1, 2, 7, 11, and 14 were moderately active against HIV-1 RT, with IC50 values of 119 microM, 100 microM, 116 microM, 236 microM, and 170 microM, respectively. Morelloflavone (7) also demonstrated significant antiviral activity against HIV-1 (strain LAV-1) in phytohemagglutinin-stimulated primary human peripheral blood mononuclear cells at an EC50 value of 6.9 microM and a selectivity index value of approximately 10. The other biflavonoids were either weakly active, inactive, or not selective against HIV-1 in human lymphocytes.

.ALPHA.-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)

“…The hexane and CH 2 Cl 2 -soluble fractions obtained from the acetone extract was subjected to repeated chromatography on silica gel column to afford four new depsidones, brevipsidones A-D (1-4) along with damnacanthal, 20) scopoletin 21) and a mixture of stigmasterol and b-sitosterol. 9 Hz, H-9) suggested a tetrasubstituted A-ring and a total substituted B ring. The location of the substituents on the molecule was determined by NOESY and HMBC experiments.…”

“…depsidones, 6,7) flavonoids 8) and biflavonoids 9) have been isolated from African and Southeast Asian species. Depsidones isolated from Garcinia are assumed to be cancer chemopreventive, cytotoxic and radical scavenging agents.…”

Fatty Acid, Tocopherol, Sterol Compositions and Antioxidant Activity of Three Garcinia Seed Oils

“…G. hanburyi was reported to show anti-inflammatory, analgesic, antibacterial, and antipyretic activities [7,8]. G. multiflora was also known for its antioxidant and antibacterial, especially anti-HIV activity [9,10]. Comparatively, the third species G. gaudichaudii was lack of bioactivity report.…”

Efeito hipolipidêmico do suco de camu-camu em ratos

“…Os polifenóis têm recebido muita atenção da comunidade científica por seus numerosos efeitos biológicos e funcionais, como a modulação do perfil lipídico e a sua função antiaterosclerótica, anti-inflamatória, antialérgica, antitumoral, anti--hepatóxica, antiulcerogênica, antimicrobiana, antiviral e vasodilatadora [11][12][13][14] .…”