In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System

Liu, Chi-Hsien; Huang, Hsiao-Yun

doi:10.1248/cpb.c12-01043

Cited by 38 publications

(21 citation statements)

References 35 publications

(43 reference statements)

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“…Recently, enhanced in vitro antibacterial activity of curcumin-loaded vesicle systems against Propionibacterium acnes in the skin was observed by Liu et al 69 . Fig.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

et al. 2016

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“…Recently, enhanced in vitro antibacterial activity of curcumin-loaded vesicle systems against Propionibacterium acnes in the skin was observed by Liu et al 69 . Fig.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

et al. 2016

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“…Shikonin, isolated from Lithospermum erythrorhizon and included in SK, has been reported to inhibit the growth of methicillin‐resistant S. aureus (MRSA) . Similarly, curcumin that is isolated from Curcuma longa and included in CK, is reported to inhibit growth of C. acnes . However, in this study, both topical medicines did not inhibit the growth of C. acnes ATCC 11828.…”

Section: Discussionmentioning

confidence: 96%

Shiunko and Chuoko, topical Kampo medicines, inhibit the expression of gehA encoding the extracellular lipase in Cutibacterium acnes

Nakase

Tashiro

Yamada

et al. 2019

The Journal of Dermatology

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Antimicrobial agents have been used for eradication of Cutibacterium (formerly Propionibacterium) acnes that is an exacerbation factor of the skin disease acne vulgaris. However, the use of antibiotics is associated with an increased risk of promoting the emergence of resistant bacteria and leading to skin dysbiosis. Traditional Japanese Kampo medicines, such as Keigairengyoto, are used to treat acne. However, there is incomplete understanding regarding their functional mechanism in treatment of acne. In this study, we examined the antimicrobial and anti‐lipase activity of the Kampo medicines used empirically for acne treatment. Three oral medicines, Keigairengyoto, Seijoboufuto and Jumihaidokuto, were found to inhibit the growth of C. acnes and decrease the lipase activity. Especially, Keigairengyoto caused remarkable decrease of bacterial lipase activity. Furthermore, topical medicines such as Shiunko and Chuoko significantly decreased the lipase activity in a dose‐dependent manner, without inhibiting C. acnes growth. The topical medicines were found to inhibit the expression of gehA, which codes for extracellular lipase. Our results indicate that Shiunko and Chuoko have potential as effective acne therapeutic agents, especially because they do not promote the emergence of antimicrobial‐resistant bacteria and skin dysbiosis.

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“…The growth of the common skin bacteria Staphylococcus epidermidis and Staphylococcus aureus is inhibited by curcumin, which also acts synergistically with several antibiotics [28,29]. When curcumin was photoactivated, it was also able to inhibit the growth of Propionibacterium acnes , though unactivated curcumin did not inhibit growth [27]. …”

Section: Edible Plants and Acnementioning

confidence: 99%

Edible Plants and Their Influence on the Gut Microbiome and Acne

Clark

Haas

Sivamani

2017

IJMS

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Acne vulgaris affects most people at some point in their lives. Due to unclear etiology, likely with multiple factors, targeted and low-risk treatments have yet to be developed. In this review, we explore the multiple causes of acne and how plant-based foods and supplements can control these. The proposed causative factors include insulin resistance, sex hormone imbalances, inflammation and microbial dysbiosis. There is an emerging body of work on the human gut microbiome and how it mediates feedback between the foods we eat and our bodies. The gut microbiome is also an important mediator of inflammation in the gut and systemically. A low-glycemic load diet, one rich in plant fibers and low in processed foods, has been linked to an improvement in acne, possibly through gut changes or attenuation of insulin levels. Though there is much interest in the human microbiome, there is much more unknown, especially along the gut-skin axis. Collectively, the evidence suggests that approaches such as plant-based foods and supplements may be a viable alternative to the current first line standard of care for moderate acne, which typically includes antibiotics. Though patient compliance with major dietary changes is likely much lower than with medications, it is a treatment avenue that warrants further study and development.

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In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System

Cited by 38 publications

References 35 publications

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

Shiunko and Chuoko, topical Kampo medicines, inhibit the expression of gehA encoding the extracellular lipase in Cutibacterium acnes

Edible Plants and Their Influence on the Gut Microbiome and Acne

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