In Vitro Anti-Urolithiasis Potentials of Argemone mexicana L. Leaves

Chilivery, Ravi Kiran; Alagar, S.; Darsini, Teepica P.

doi:10.2174/1574884711666161010143649

Cited by 7 publications

(3 citation statements)

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“…In traditional medicine, it is useful in treating dropsy, jaundice, ophthalmia, scabies, and urinary stones [ 35 ]. An in vitro study showed that the methanolic extract of A. mexicana L. leaves promoted a significant inhibition of nucleation (72.3%) and aggregation (77.2%) compared to the cystone and drug (62.9 and 69.33%, respectively) [ 36 ]. In another study in an animal model of UL induced by ethylene glycol (EG), the oral administration of an extract from A. mexicana L. (400 and 750 mg/kg) for 13 days promoted regulation of the concentration of serum urea, nitrogen, and creatinine.…”

Section: Plants Used In Mexican Traditional Medicine Against Urolithi...mentioning

confidence: 99%

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as Argemone mexicana L., Berberis trifoliata Hartw. ex Lindl., Costus mexicanus Liebm, Chenopodium album L., Ammi visnaga (L.) Lam., Eysenhardtia polystachya (Ortega) Sarg., Selaginella lepidophylla (Hook. & Grev.) Spring, and Taraxacum officinale L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.

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Section: Plants Used In Mexican Traditional Medicine Against Urolithi...mentioning

confidence: 99%

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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“…Several medicinal plant species have been investigated for their effect in treating urolithiasis both in in vitro and in vivo (Chilivery et al, 2016;Abu Zarin et al, 2020;Mosquera et al, 2020). The plant selected for this study is widely used for the treatment of renal calculi or to prevent their formation (Badshah and Hussain, 2011;Mikaili et al, 2012;Muhammad et al, 2015;Varshochi and Asadollahi, 2015).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the potential anti-urolithiatic activity of Alhagi maurorum (Boiss.) grown wild in Al-Ahsa (Eastern Province), Saudi Arabia

et al. 2024

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The potential of Alhagi maurorum (Boiss.) aqueous extract (AME), used in traditional medicine for treatment or prevention of urolithiasis, to dissolve calcium oxalate stones in vitro was evaluated. In order to determine the litholytic potential of the extract, Calcium oxalate urinary stones were incubated during 12 weeks under continuous shaking in the presence of AME, Rowanix or NaCl 9 g/mL solution were used as controls. After the incubation period, the residual weight of the treated calculi was determined and the rate of dissolution was calculated. The medium pH variation was measured and changes in the calcium oxalate crystals at the stone surface were assessed using a scanning electron microscope (SEM). The results showed a significant dissolution effect for the extract on the kidney calculi during the experimentation period. At the end of the experiment, the percentages of calculi weight decrease were 41.23, 4.97 and 55.67% for the extract, NaCl solution and Rowanix, respectively. Gas Chromatography analysis revealed mainly the presence of the following phyto-compounds: Cyclopropenone, 2,3-diphenyl; 1-Nonadecanol; methyl-alpha-D-mannopyranoside; cis-9-Hexadecenal. These compounds unarguably play crucial roles in the health care system especially in cancer treatment and many other diseases including urolithiasis. The urinary stone dissolution, independent of medium pH, could be attributed to formation of complexes between the phytochemical compounds in the extract and the calculi.

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“…Phytochemicals from various parts possess bioactivities including anti-drug abuse agent (Capasso et al 1997), anticancer activity against human nasopharyngeal carcinoma (HONE-1) cancer, human gastric cancer, human colon cancer cells (Chang et al 2003b;Gali et al 2011;Singh et al 2016;More and Kharat 2016;Hussain et al 2018), anti-stress and anti-allergic (Bhalke and Gosavi 2009), antioxidant (Perumal et al 2010;Bhardwaj et al 2011;Apu et al 2012;Asuntha et al 2015;Kushtwar and Anurag 2016), anti-gastric ulcer (Das et al 2011), hepatoprotective (Das et al 2009;Adam et al 2011;Sourabie et al 2012;Bhat et al 2014), analgesic and sedative (Anarthe and Chaudhari 2011), anxiolytic (Anarthe and Chaudhari 2011;Arcos-Martínez et al 2016), wound-healing (Patil et al 2001;Dash and Murthy 2011;Saravanan et al 2017), clot lysis/thrombolytic (Apu et al 2012), anti-diabetic (Nayak et al 2011), aldose reductase (Gupta et al 2014), hypoglycaemic (Rout et al 2011), antimalarial (Simoes-Pires et al 2014, anti-status epilepticus and anti-oxidative stress (Asuntha et al 2015), antiurolithiatic (Chilivery et al 2016), larvicidal (Rothe et al 2016), biopesticide (Das and Sukul 1988;Singh et al 1993;von Weizsäckerl 1995;Chitra et al 1997;Saxena and Tabassum 2000;Shaukat et al 2002)…”

Section: Bioactivitiesmentioning

confidence: 99%