In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.

Park, Junho; Lee, Jongsung; Jung, Eunsun; Park, Yumi; Kim, Kukhyun; Park, Byunghwa; Jung, Kwangseon; Park, Eunkyung; Kim, Jieun; Park, Deokhoon

doi:10.1016/j.ejphar.2004.05.047

Cited by 228 publications

(147 citation statements)

References 18 publications

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“…The potent activity of honokiol and magnolol appears to be due to the presence of hydroxyl and allylic groups on a biphenolic moiety (10 Magnolol, a hydroxylated biphenyl compound isolated from the stem bark of Magnolia officinalis, is commonly used to treat acute pain, cough, anxiety, and gastrointestinal disorders in East Asia (11). Various pharmacological actions have been reported for magnolol, including anti-inflammatory activity, antimicrobial activity (12), antiperoxidative activity (13), anti-coagulatory activity, anti-oxidant activity (14), neuroprotective activity (15), antitumor action (16)(17)(18), alleviation of inflammatory pain (19), and protection of cortical neuronal cells from chemical hypoxia (20).…”

Section: Magnolol and Honokiolmentioning

confidence: 99%

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis

Tang

Du³

et al. 2011

DD&T

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Magnolol and honokiol, main active compounds from the bark of Magnolia officinalis, have been found to have various pharmacological actions, including anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties, without appreciable toxicity. Recently, the anti-tumor activity of magnolol and honokiol has been extensively investigated. Magnolol and honokiol were found to possess anti-tumor activity by targeting the apoptosis pathways, which have been considered as targets for cancer therapies. This review will focus on the mechanisms by which magnolol and honokiol act on apoptosis pathways in cancer that have been characterized thus far, including the death receptormediated pathway, mitochondria-mediated pathway, caspase-mediated common pathway, and regulation of apoptosis-related proteins. These breakthrough findings may have important implications for targeted cancer therapy and modern applications of traditional Chinese medicine.

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Section: Magnolol and Honokiolmentioning

confidence: 99%

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis

Tang

Du³

et al. 2011

DD&T

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“…It is known that some plant extracts and essential oil from herbs have antimicrobial activity [5][6][7]. For example, the essential oils of Rosmarinus officinalis and Cinnamomum zeylanicum have been used for their antimicrobial properties [8][9][10].…”

Section: )mentioning

confidence: 99%

Development of Antimicrobial Plant Extracts and its Application to Cosmetics

Lee¹,

Lee²,

Lee³

et al. 2012

Journal of the Society of Cosmetic Scientists of Korea

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This study is focused on finding new natural materials that have antimicrobial activity. We found that 3 plants extracts, Magnolia sieboldii K. Koch (M. sieboldii K. Koch), Rhus chinensis (R. chinensis) and Metasequioa glyptostroboides (M. glyptostroboides), have antimicrobial activities by disk diffusion method. We determined the Minimum Inhibitory Concentation (MIC) of each and found that 0.3 ∼ 0.35 % of M. glyptostroboides essential oil and 0.35 ∼ 0.4 % of M. sieboldii K. Koch extracts inhibited fungal growth and 0.45 ∼ 0.5 % of R. chinensis extracts inhibited bacterial growth. We isolated compounds from extracts and verified what have antimicrobial activity. As a result we found that caryophyllene oxide and caryophyllene isolated from M. glyptostroboides, costunolide and dehydrocostus lactone from M. sieboldii K. Koch and ethyl gallate, ethyl-3-gallate from R. chinensis have antimicrobial activities. In accordance with antimicrobial activity, O/W cosmetic emulsion containing mixture of 3 plants extracts showed preservative efficacy against both bacteria and fungi. Based on the above data we suggest that extracts from M. siebodii K. Koch, R. chinensis, and M. glyptostroboides, replace chemical synthetic preservatives and be applied as a natural preservative.

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“…Honokiol is a bioactive constituent in Magnoliae officinalis cortex and recent investigations have shown that honokiol possess a wide range of physiological activities, such as antitumor [4], antimicrobial [5], and antiinflammatory activity [6]. Antioxidant activity in vitro of Magnoliae officinalis cortex and honokiol have also been reported [7,8].…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhea and antioxidant activities of Honokiol extract from Magnoliae officinalis cortex in mice

Han¹,

Pang²,

Liu³

et al. 2014

Trop. J. Pharm Res

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Purpose: To evaluate the antidiarrhea and antioxidant properties of honokiol extracted from Magnoliae officinalis cortex (bark of Magnolia officinalis), an important medical material in traditional Chinese 16 % in comparison with -neostigmine control group-(59.0 % vs. 70 .1%). Compared with control (no honokiol), the activities of catalase (CAT), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) in the plasma (CAT, 7.31 vs. 13.21 U/mL; 439.6 vs. 608.9 U/m; 82.2 vs. 109.8 U/mL) and liver (CAT, 7.73 vs. 14.39 U/mg; 167.6 vs. 202.7 U/mg; 44.3 vs. 53.9 U/mg) were significantly enhanced by honokiol (p < 0.01). CAT and GSH-Px gene expressions were also significantly enhanced by honokiol (p < 0.05), compared with control (no honokiol) (CAT, 0.32 vs. 0.39; 4.49 vs. 5.80

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In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.

Cited by 228 publications

References 18 publications

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i>

Development of Antimicrobial Plant Extracts and its Application to Cosmetics

Antidiarrhea and antioxidant activities of Honokiol extract from <i>Magnoliae officinalis cortex</i> in mice

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