In vitro antibacterial and antifungal activities of Tabernaemontana heyneana Wall. leaves

Abstract

Medicinal plants are the oldest source of pharmacologically active compounds and provided virtually the only source of medicinally useful compounds for centuries. They contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments. The increased likelihood of acute infections and inflammatory conditions in early humans could have set the stage for the natural selection of the use of medicinal herbs high in antimicrobial and anti-inflammatory components. In the present study, the in vitro antibacterial and antifungal activities of different solvent leaf extracts of T. heyneana Wall. was investigated. K. pneumoniae (26±1.0 mm) and S. typhii (9.0±2.0 mm) were proved to be inhibited maximally and minimally by the leaves of T. heyneana. Similarly, the maximum and minimum antifungal effect was observed against Rhizopus mucor (25±0.0 mm) and Trichoderma viridins (6.0±1.0 mm), respectively. Among the solvents methanol was proved to be the best one in the extraction of antimicrobial compounds. Ethanol and aqueous systems were proved to be moderate and chloroform as poor solvent in extracting antimicrobial components. Overall results has proved that T. heyneana leaves possess significant antibacterial and poor antifungal activities.

Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis

“…The antioxidant activity of the raw extract from the aerial parts of T. catharinensis was lower than that observed in root ethanolic extracts of this species (IC 50 = 100  μ g/mL) [32] but higher than that identified in ethanolic extracts of T. heyneana leaves (IC 50 = 537  μ g/mL) [33]. …”

In Vitro Investigation of the Antioxidant and Cytotoxic Potential of Tabernaemontana ventricosa Hochst. ex A. DC. Leaf, Stem, and Latex Extracts

“…The highest number of flavonoids were observed for the stem hexane (946.92 ± 6.29 mg QE/g), latex (768.96 ± 5.43 mg QE/g), stem chloroform (693.24 ± 4.12 mg QE/g), and leaf hexane (662.20 ± 1.00 mg QE/g) extracts respectively whereas the lowest amount was observed for the leaf and stem methanol extracts (Table 3). The total flavonoid content of T. ventricosa extracts showed contrasting results compared to studies by Sathishkumar and Baskar [52]. In their study, the total flavonoid content in the fresh leaves of Tabernaemontana heyneana was much lower with a value of 4.4 ± 0.17 mg QE/g [52].…”

“…The total flavonoid content of T. ventricosa extracts showed contrasting results compared to studies by Sathishkumar and Baskar [52]. In their study, the total flavonoid content in the fresh leaves of Tabernaemontana heyneana was much lower with a value of 4.4 ± 0.17 mg QE/g [52]. However, it has been reported that the accumulation of flavonoids is often associated with drought-tolerant plants, such as the Arabidopsis species [53].…”

L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India)

“…The stem bark, bitter roots, flowers, and latex of fruits are used in folk medicine to treat diseases of skin and toothache and to reduce inflammation [5]. The indole alkaloids and terpenoids isolated from the roots, stem bark, fruits, and leaves possess cytotoxic, anti-implantation, and antioxidant properties [6–8]. …”