In vitro antibacterial and antifungal activities of binuclear transition metal complexes of ONNO Schiff base and 5-methyl-2,6-pyrimidine-dione and their spectroscopic validation

Srivastva, Abhay Nanda; Singh, Netra Pal; Shriwastaw, Chandra Kiran

doi:10.1016/j.arabjc.2014.10.004

Cited by 57 publications

(29 citation statements)

References 55 publications

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“…The molar conductivities of 10 −3 M solution complexes dissolved in DMF were recorded at room temperature and the values reported in Table . The results obtained for the conductivity measurements of the compounds were found in the range of 11–20 Ω −1 mol −1 cm 2 reveals that all the metal complexes have very low conductivity values which were characteristics for their non‐electrolytic nature …”

Section: Resultsmentioning

confidence: 89%

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Devi

Yadav

Jindal

et al. 2019

Applied Organom Chemis

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A series of twenty compounds inclusive of bidentate Schiff bases derived from condensation of 4‐methyl‐3‐thiosemicarbazide with substituted derivatives of napthaldehyde/benzaldehyde/salicylaldehyde and their mononuclear Co (II), Ni (II), Cu (II) and Zn (II) complexes in molar ratio (1:1) were synthesized and characterized. The coordination behavior, modes of bonding and overall geometry of the compounds was known from the elemental analysis, spectral techniques (IR, UV–Vis, 1H NMR, 13C NMR, ESR and ESI‐mass), magnetic moment measurements, molar conductance, thermal and powder XRD studies. The studies revealed octahedral geometry for all the complexes where ligands coordinated in a neutral bidentate manner (NS) via nitrogen atom of azomethine group and sulphur atom of thione group with the metal centre. In vitro biological effects of the compounds were tested against four bacterial species and two fungal strains. The results indicated that the metal complexes showed a marked enhancement in biocidal activity in comparable with the parent Schiff bases. In vitro anticancer activity against the malignant tumor cell lines; human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and human normal lung cell line (MRC‐5) using MTT assay, exposed compound 16 as a leading member with lowest IC50 value of 10.6 ± 0.14 μM against (A549) cell line.

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Section: Resultsmentioning

confidence: 89%

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Devi

Yadav

Jindal

et al. 2019

Applied Organom Chemis

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“…Schiff bases contains azomethine (-C=N-) linkage and are usually derived by the condensation of carbonyl compounds (aldehydes/ketones) with primary aliphatic/aromatic/heteroaromatic amines. Schiff bases are known for their antitumor [1, 2, 3, 4, 5, 6, 7, 8], antifungal [9, 10, 11, 12, 13], antiviral [14], antibacterial [9, 10, 11, 12, 15, 16, 17] and anticancer [18, 19] activities. Schiff bases find many applications including acid catalyst [20, 21, 22, 23], reduction catalyst [24, 25], oxidation catalyst [26, 27, 28, 29, 30, 31], dye [32, 33] and it also exhibit special liability towards metal ions [34, 35, 36, 37].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Vhanale

Deshmukh

Shinde

2019

Heliyon

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The four Schiff bases (I - IV) were synthesized by the condensation reaction of 1(1-hydroxynaphthalen-2-yl)ethanone, 1-(4-chloro-1hydroxynaphthalen-2-yl)ethanone and 1-(4-bromo-1-hydroxynaphthalen-2-yl)ethanone with propane-1,3-diamine and pentane-1,3-diamine. The structural analysis is done by UVvis., FT-IR, 1H NMR, 13C NMR, LCMS and elemental analyses. These compounds were assayed for antibacterial (Escherichia coli and Salmonella Typhi) activity and antioxidant (2,2-Diphenyl-1-Picryl Hydrazyl(DPPH) and Hydroxyl radical scavenging method) activity. The antibacterial and antioxidant activities of synthesized Schiff bases exhibited better degrees of inhibitory effects. Among these, Schiff base 2,2'-((propane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(4-chloronaphthalen-1-ol) (II) exhibited excellent antibacterial activity with MICs of 0.12, 0.25, 0.5 and 1 mg/ml against E. coli and Salmonella Typhi. Furthermore, two Schiff bases such as, 2,2'-((propane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(naphthalen-1-ol) (I) and 2,2'-((pentane-1,3-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(4-bromonaphthalen-1-ol) (IV) exhibited promising antioxidant activity.

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“…The Cu(II) complex in comparison to all other complexes, is more toxic and effective towards the microbes-S. aureus, B. species, and K. pneumonia with inhibitory zone values of 31.3, 25.7 and 19.7 mm respectively, and to the standard (streptomycin) with respective inhibition values of 22.0, 22.0 and 24.0 mm. Result of this kind, in which test compounds have greater antibacterial efficacy than the standard-streptomycin has been reported [36][37][38].…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Biological evaluation and molecular docking of some newly synthesized 3d-series metal(II) mixed-ligand complexes of fluoro-naphthyl diketone and dithiocarbamate

2020

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A series of some 3d (Mn, Fe, Co, Ni, Cu and Zn) metal(II) complexes of mixed-ligands-N,N′-dimethyldithiocarbamate (SDTC) and 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione (TFNB) have been synthesized and presented for antioxidant, antibacterial and antifungal studies. The complexes were examined for their in-vitro antioxidant potentials by employing ferrous ion chelating and DPPH scavenging methods, while the in-vitro antimicrobial screening of the unbound ligands and their mixed metal(II) complexes against bacteria-Staphylococcus aureus, Bacillus cereus (Gram (+ve)), Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli (Gram (−ve)), and fungi-Aspergillus niger, Aspergillus flavous, Fusarium species using agar and disc diffusion methods respectively. The studies revealed that Co(II) complex had the highest antioxidant potential with the percentage scavenging inhibition of 75.04%. The antimicrobial screening of the complexes against the bacterial microbes showed that Cu(II) complex had the best activity with inhibitory zone range of 19.7-31.3 mm; while Fe(II) complex possesses highest fungicidal activities within the inhibitory zone range of 28.7-38.0 mm; compared to other complexes against the fungi strains. Molecular docking approach indicated that Cu(II) complex had higher binding affinity with π-sulphur and Van der Waals interactions.

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In vitro antibacterial and antifungal activities of binuclear transition metal complexes of ONNO Schiff base and 5-methyl-2,6-pyrimidine-dione and their spectroscopic validation

Cited by 57 publications

References 55 publications

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Synthesis, characterization, spectroscopic studies and biological evaluation of Schiff bases derived from 1–hydroxy-2-acetonapthanone

Biological evaluation and molecular docking of some newly synthesized 3d-series metal(II) mixed-ligand complexes of fluoro-naphthyl diketone and dithiocarbamate

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