In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells

Jang, Suk Ju; Yang, In Jun; Tettey, Clement Okraku; Kim, Ki Mo; Shin, Heung Mook

doi:10.1016/j.msec.2016.03.101

Cited by 116 publications

(42 citation statements)

References 31 publications

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“…Currently, a large number of methods like biological ones can be used to synthesize different types of nanoparticles [134]. In order to avoid adverse effects during synthesis and application of nanoparticles, there is a growing need to develop eco-friendly and sustainable methods for synthesizing nanomaterials that do not use toxic chemicals during the process [135].…”

Section: Metallic Nanoparticles Methodsmentioning

confidence: 99%

“…In order to avoid adverse effects during synthesis and application of nanoparticles, there is a growing need to develop eco-friendly and sustainable methods for synthesizing nanomaterials that do not use toxic chemicals during the process [135]. Nowadays, green synthesis of metallic nanoparticles is a growing area of research because of their potential applications in different domains [134].…”

Section: Metallic Nanoparticles Methodsmentioning

confidence: 99%

“…Among the these nanoparticles, AgNPs may have considerable potential for development as cytoxic agent because of their unique properties to enhance potential therapeutic efficacy [134].…”

Section: Antitumor Activitymentioning

confidence: 99%

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Recent advances in the identification and the study of composition and activities of medicinal plants

2016

J Coast Life Med

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Section: Metallic Nanoparticles Methodsmentioning

confidence: 99%

Section: Metallic Nanoparticles Methodsmentioning

confidence: 99%

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Recent advances in the identification and the study of composition and activities of medicinal plants

2016

J Coast Life Med

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“…A key point in anticancer therapy is to have drugs or molecules that are highly selective to kill cancer cells. In the literature there are green silver nanoparticles with anticancer activity but their cytotoxic effects have not been evaluated in normal cells [21,30,33,37,39,42], others show that there is little selectivity for cancer cells [14,34] and other studies show encouraging anticancer activity due to a better degree of selectivity [32,35,36,40,41,43,45]. An advantage of the use of medicinal plant extracts is the opportunity to be able to functionalize silver nanoparticles to enhance their anticancer effect and improve their specificity of action on cancer cells without affecting nontumor cells; this represents a challenge for scientists.…”

Section: Anticancer Activitymentioning

confidence: 99%

Green Silver Nanoparticles: Novel Therapeutic Potential for Cancer and Microbial Infections

Ortiz¹

2017

JNMR

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The nanomedicine is opening borders by designing and testing both novel devices for clinical diagnosis and new therapies based on chemical nanostructures that exert their direct biological action or acting as pharmacological carriers. The development of new eco-friendly chemical synthesis methods opened a field of opportunity for nanomedicine and in the last years a great number of metallic nanoparticles have been synthesized through green chemical synthesis using natural plant extracts (leaf, stem, peel, bark, fruits). This review it shows an overview of the current status with silver nanoparticles synthesized by green chemical methods regarding their therapeutic potential for use in the treatment of microbial infections and cancer. The analysis carried out in recent publications shows that green silver nanoparticles have high antimicrobial activity (antibacterial, antifungal and antiviral) which can be enhanced with the addition of functional groups contained in the natural extracts used during the synthesis. In addition, there are many studies in different types of cancer that show the anticancer activity of green silver nanoparticles. This study shows that green synthesis has improved the selectivity of biological action and the biocompatibility of silver nanoparticles, these results are encouraging for treatment of cancer and microbial infections in humans.

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“…Zhang et al [21] combined silver nanoparticles with hydrogel to promote bone regeneration in infected bone defects. Basic research in oncology demonstrated that AgNPs had apoptotic effects on MCF-7 human breast cancer cells and could block the growth of prostate cancer (PC-3) cells [22,23]. Therefore, AgNPs have recently become an indispensable component for biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Xanthan-Based Film Incorporated with Silver Nanoparticles for Potential Application in the Nonhealing Infectious Wound

Huang

Ren

Chen

et al. 2017

Journal of Nanomaterials

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Xanthan gum is a high molecular weight polysaccharide biocompatible to biological systems, so its products promise high potential in medicine. In this study, we crosslinked xanthan gum with citric acid to develop a transparent film for protecting the wound. Silver nanoparticles (AgNPs) are incorporated into the film to enhance the antimicrobial property of our biomaterial. This paper discussed the characteristics and manufacturing of this nanocomposite dressing. The safety of the dressing was studied using fibroblasts (L929) by the method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and staining of ethidium homodimer (PI) and calcein AM. The bacterial inhibition test and application of the dressing to nonhealing wounds infected with methicillin-resistant S. aureus (MRSA) were performed to evaluate the antibacterial effects in vitro and in vivo, respectively. The results indicated that the dressing could restrict the formation of biofilms, reduce inflammatory reactions, and promote the angiogenesis of granulation tissues in infectious wounds. Therefore, this dressing has a great advantage over traditional clinical products especially when administered under the condition of infections or for the purpose of infection prevention.

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In-vitro anticancer activity of green synthesized silver nanoparticles on MCF-7 human breast cancer cells

Cited by 116 publications

References 31 publications

Recent advances in the identification and the study of composition and activities of medicinal plants

Recent advances in the identification and the study of composition and activities of medicinal plants

Green Silver Nanoparticles: Novel Therapeutic Potential for Cancer and Microbial Infections

Evaluation of the Xanthan-Based Film Incorporated with Silver Nanoparticles for Potential Application in the Nonhealing Infectious Wound

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