In vitro Anticancer Activity of Quinoa and Safflower Seeds and Their Preventive Effects on Non-alcoholic Fatty Liver

Mohamed, Doha A.; Fouda, Karem; Mohamed, Rasha S.

doi:10.3923/pjbs.2019.383.392

Cited by 34 publications

(28 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Almond content of unsaturated fatty acid, phytosterol, fiber, and other bioactive components ( Berryman et al., 2011 ) may be contributed to the beneficial effect of the prepared beverage on kidney and liver functions. Mohamed et al. (2019) confirmed that quinoa seeds suppressed the elevation in kidney and liver functions which mediated by feeding rats on diet rich in fructose and contained saturated fat.…”

Section: Resultsmentioning

confidence: 60%

“…The superiority of the beverage II in radical scavenging activity may be attributed to the antioxidant activity and phenolic compounds content of carrot and quinoa seeds as confirmed by Sharma et al. (2012) and Mohamed et al. (2019) , respectively.…”

Section: Resultsmentioning

confidence: 85%

“…Non-significant ( p > 0.05) differences in the body weight gain were observed in the metabolic syndrome control rats in comparison to normal control rats. Mohamed et al. (2019) also found that feeding rats on diet rich in fructose and contained saturated fat did not produce a significant change in the body weight gain.…”

Section: Resultsmentioning

confidence: 88%

“…Significant differences ( p ≤ 0.05) were found in all measured parameters of the prepared beverage, except pH and acidity. From this table, it could be seen that the beverage II contained the highest protein, fat, and carbohydrate content being 5.22 %, 0.5% and 12.56%, respectively may be due to the presence of quinoa seeds powder which is considered a rich source of protein and carbohydrate ( Mohamed et al., 2019 ). Regarding the physicochemical parameters, also the beverage II showed the highest total solids percent and viscosity which also can be attributed to the presence of quinoa seeds powder.…”

Section: Resultsmentioning

confidence: 99%

“…Also, the ratio of T-Ch to HDL-Ch and TGs to HDL-Ch reduced significantly in rats given oral administration of the prepared beverages in comparison to metabolic syndrome control rats but still significantly different than normal control. The hypolipidemic and anti-atherosclerotic effects of the prepared beverage may be attributed to their content of not only the polyunsaturated fatty acids in almond ( Keser et al., 2014 ) and quinoa seeds ( Mohamed et al., 2019 ) but also to the bioactive therapeutic peptides ( Siddiqui et al., 2020 ) and the phenolic compounds which possess lipid-lowering effect in the liver and can regulate genes expression that involved in lipogenesis and fatty acid oxidation ( Pisonero-Vaquero et al., 2015 ). Reduction of cholesterol and lipid absorption, adjusting postprandial insulin response, promoting cholesterol conversion to bile acids, and improving gut microbiota can be mediated by the dietary fiber ( De Carvalho et al., 2014 ).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Fortified vegetarian milk for prevention of metabolic syndrome in rats: impact on hepatic and vascular complications

Hussein

Fouda

Mehaya

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is characterized as a gathering of various metabolic disorders, for example, hyperglycemia, dyslipidemia, and obesity. The present research was conducted to prepare fortified almond milk as functional beverages and evaluate their protective effect against MetS and associated hepatic and vascular complications. Three beverages (I, II, and III) were prepared by fortification almond milk with carrot juice or powder of quinoa seeds and carrot juice or oat powder and banana juice. The sensory attributes, physicochemical properties, bioactive compounds (total phenolic, beta-carotene, tocopherols) and B-complex vitamins were determined in the beverages. In-vitro antioxidant activity of the beverages was assessed. MetS was induced in rats via feeding on high-fat high-fructose diet (HFHF). The biochemical (lipid profile, oxidative stress, liver, and kidney functions), nutritional and histopathological parameters were assessed in rats. The beverage I recorded the highest sensory attributes' scores. The physicochemical properties of the beverages revealed that acidity and viscosity of all beverages ranged from 4.55 to 4.88 and from 40 to 59, respectively. The beverage I showed the highest content of alpha-tocopherol (14.994 μg/g) and beta-carotene (104.541 μg/g), while the beverage II showed the highest content of gamma-tocopherol (0.557 μg/g), folic acid (0.806 μg/g), and total phenols (147.43 μg GAE/g). The results of animals revealed that the beverage II was the most promising in attenuation levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and tumor necrosis factor-alpha. Also, the beverage II was the superior in the protection of the liver and heart tissues as reflected by the histopathological examination findings. So, it can be concluded that the newly prepared almond milk with quinoa seeds and carrot juice could be used as an effective functional beverage for the prevention of MetS and its complications.

show abstract

Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Fortified vegetarian milk for prevention of metabolic syndrome in rats: impact on hepatic and vascular complications

Hussein

Fouda

Mehaya

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

show abstract

Pseudocereals

Sánchez‐Velázquez

Manzanilla‐Valdez

Mondor

et al. 2022

Molecular Mechanisms of Functional Food

View full text Add to dashboard Cite

The functional ingredients of quinoa (Chenopodium quinoa) and physiological effects of consuming quinoa: A review

Wang

2021

Food Frontiers

View full text Add to dashboard Cite

The seed of quinoa (Chenopodium quinoa) is a pseudocereal well known for its high nutritive value. The purpose of this review is to evaluate the potential for it to be used as a functional food. The nutritional composition, phytochemicals, and experimental evidence on its bioactivities are introduced to evaluate the physiological effects of consuming quinoa, including its antioxidant, hypolipidemic, immunomodulatory, weight‐regulating, hypoglycemic, hypotensive, probiotic, antitumor, and hormone‐regulating effects. The antinutrients, allergenicity, and toxicity of quinoa are then discussed. Overall, many studies and evidences have suggested the functional properties of quinoa, with most of them focusing on the antioxidant and hypolipidemic ability. Compared with the potential benefits, the risk of consuming quinoa is relatively low and easy to be managed. Therefore, quinoa can be considered to have great potential to be promoted as a healthy/functional food. More investigations are needed to confirm the effective intake of quinoa for achieving certain health effects.

show abstract

In vitro Anticancer Activity of Quinoa and Safflower Seeds and Their Preventive Effects on Non-alcoholic Fatty Liver

Cited by 34 publications

References 50 publications

Fortified vegetarian milk for prevention of metabolic syndrome in rats: impact on hepatic and vascular complications

Fortified vegetarian milk for prevention of metabolic syndrome in rats: impact on hepatic and vascular complications

Pseudocereals

The functional ingredients of quinoa (Chenopodium quinoa) and physiological effects of consuming quinoa: A review

Contact Info

Product

Resources

About