In vitro antifilarial effects of three plant species against adult worms of subperiodic Brugia malayi

Zaridah, M.Z.; Idid, Syed Zahir Idid Syed Osman; Omar, Ainsah; Khozirah, S.

doi:10.1016/s0378-8741(01)00286-0

Cited by 73 publications

(44 citation statements)

References 7 publications

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“…Tinospora crispa Miers (family Menispermaceae) is used to treat jaundice, rheumatism, intermittent fever (Siddiqi et al, 1974;Noor and Ashcroft, 1998), malaria (Bertani et al, 2005), filariasis (Zaridah et al, 2001) and also well known for anti-inflammatory, antispasmodic properties (HMR, 2002;Singh et al, 2003). Psidium guajava L. (from family Myrtaceae) has been employed for treating various diseases such as relieving cough, pulmonary disorders, wounds, and ulcers.…”

Section: Introductionmentioning

confidence: 99%

Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa

Lee

Mahmud

Noordin

et al. 2012

Bangladesh J Pharmacol

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Section: Introductionmentioning

confidence: 99%

Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa

Lee

Mahmud

Noordin

et al. 2012

Bangladesh J Pharmacol

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“…Andrographis paniculata and Barringtonia acutangula extracts provided around 50% viable cells from extract treatments without venom preincubation and expected scorpion venom antidotes with low cytotoxicity (Uawonggul et al 2006); the extract of A. paniculata or andrographolide were found to enhance IgG antibody levels against Salmonella typhimurium, the enhancement being statistically significant in mice (Xu et al 2007); the crude extract showed potent antibacteria properties (Zaidan et al 2005); isolated six new ent-labdane diterpenoids were evaluated for their inhibitory activity against several bacterial and fungal strains (Shen et al 2006). Zaridah et al (2001) have reported that the aqueous extract from dried leaves of A. paniculata was tested in vitro against adult worms of Brugia malayi. Cocculus hirsutus is a widely growing plant found in the plains of India in dry localities and is used medicinally by the Indian tribes for a wide range of ailments, including constipation and kidney problems (Caius 1986;Usher 1984); the aerial parts aqueous extract showed significant diuretic activity and laxative effect in rats (Ganapaty et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Laboratory study on larvicidal activity of indigenous plant extracts against Anopheles subpictus and Culex tritaeniorhynchus

Elango¹,

Rahuman²,

Bagavan³

et al. 2009

Parasitol Res

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Anopheles subpictus and Culex tritaeniorhynchus have developed resistance to various synthetic insecticides, making its control increasingly difficult. Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. The leaf acetone, chloroform, ethyl acetate, hexane, and methanol extracts of Aegle marmelos (Linn.) Correa ex Roxb, Andrographis lineata Wallich ex Nees., Andrographis paniculata (Burm.f.) Wall. ex Nees., Cocculus hirsutus (L.) Diels, Eclipta prostrata L., and Tagetes erecta L. were tested against fourth-instar larvae of malaria vector, A. subpictus Grassi and Japanese encephalitis vector, C. tritaeniorhynchus Giles (Diptera: Culicidae). All plant extracts showed moderate larvicidal effects after 24 h of exposure at 1,000 ppm; however, the highest larval mortality was found in leaf ethyl acetate of A. marmelos, E. prostrata, hexane, methanol of A. paniculata and C. hirsutus against the larvae of A. subpictus (LC(50) = 167.00, 78.28, 67.24, 142.83 ppm; LC(90) = 588.31, 360.75, 371.91, and 830.01 ppm) and against the larvae of C. tritaeniorhynchus (LC(50) = 99.03, 119.89, 88.50, 105.19 ppm; LC(90) = 479.23, 564.85, 416.39, and 507.86 ppm), respectively. These results suggest that the leaf hexane extract of A. paniculata and ethyl acetate extract of E. prostrata have the potential to be used as an ideal eco-friendly approach for the control of the A. subpictus and C. tritaeniorhynchus. Therefore, this study provides first report on the mosquito larvicidal activity of plant extracts against vectors from Southern India.

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“…The movement of the worms was recorded microscopically for 6 h interval up to 24 h. The movement of the worms was assessed as whole body movement (score of 3), only part of body movement (score of 2), immobile but response to stimuli (score of 1), and no response or dead (score of 0). The movability index (MI) and relative movability (RM) were calculated according to Zaridah et al (2001).…”

Section: In Vitro Microfilaricidal Efficacy and Relative Movabilitymentioning

confidence: 99%

Diospyros perigrenabark extract induced apoptosis in filarial parasiteSetaria cervithrough generation of reactive oxygen species

Saini

Mukherjee

et al. 2015

Pharmaceutical Biology

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Context: Lymphatic filariasis is a major neglected tropical disease. Diospyros perigrena Gurke (Ebenaceae) was selected for antifilarial chemotherapy because of unavailability of proper medicine. In India, different parts of this plant were used for the treatment of diabetes, diarrhea, dysentery, cholera, mouth ulcers, and wounds.Objective: The present study was undertaken to access antifilarial potential and mechanism of action of n-butanol extract (NBE) of D. perigrena stem bark on Setaria cervi Rudolphi (Onchocercidae). Materials and methods: In vitro efficacy and apoptotic mechanism were evaluated by Hoechst, TUNEL, DNA fragmentation assay, pro-and anti-apoptotic gene expression in NBE (250, 125, 62.5, 31.25, and 15.6 mg/ml)-treated S. cervi after 24 h of incubation. Reactive oxygen species (ROS) up-regulation was also determined by GSH, GST, SOD assays, and super oxide anion level.Results: Significant in vitro antifilarial activity of NBE was found 50% inhibitory concentration (IC 50 ): adult ¼ 57.6 mg/ml, microfilariae (mf) ¼ 56.1 mg/ml, and lethal dose (LD 100 ) in mf is 187.17 mg/ml) after 24 h of treatment. NBF-induced apoptosis was proved by Hoechst, TUNEL, RT-PCR, and Western blot method. NBF (250 mg/ml) decreased the level of GSH (17.8%) and GST (65.4%), increased SOD activity (1.42-fold) and super oxide anion production (1.32-fold) in the treated parasite which culminated into ROS up-regulation. Discussion and conclusion: NBE induced apoptosis in different life cycle stages of S. cervi. In future, a detailed study of NBF will give us a novel antifilarial compound which will be used for antifilarial chemotherapy.

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In vitro antifilarial effects of three plant species against adult worms of subperiodic Brugia malayi

Cited by 73 publications

References 7 publications

Alkaloids content, cytotoxicity and anti-<i>Toxoplasma gondii</i> activity of <i>Psidium guajava</i> L. and <i>Tinospora crispa</i>

Alkaloids content, cytotoxicity and anti-<i>Toxoplasma gondii</i> activity of <i>Psidium guajava</i> L. and <i>Tinospora crispa</i>

Laboratory study on larvicidal activity of indigenous plant extracts against Anopheles subpictus and Culex tritaeniorhynchus

Diospyros perigrenabark extract induced apoptosis in filarial parasiteSetaria cervithrough generation of reactive oxygen species

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