In Vitro Antifungal Activity of Dihydroxyacetone Against Causative Agents of Dermatomycosis

Stopiglia, Cheila Denise Ottonelli; Vieira, Fabiane Jamono; Mondadori, Andressa Grazziotin; Oppe, Tércio Paschke; Scroferneker, Maria Lúcia

doi:10.1007/s11046-010-9370-x

Cited by 16 publications

(6 citation statements)

References 19 publications

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“…The four main constituents of the ASO HM extraction were: i) Dihydroxyacetone (19.16%), a ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. It is used in treatment of vitiligo, as antifungal, and photoprotector (FESQ et al, 2001;FUSARO and RICE, 2005;STOPIGLIA et al, 2011);…”

Section: Resultsmentioning

confidence: 99%

Analysis of the chemical constituents of Thompson atemoya seed oil

Venceslau

Mendonça

Benedick³

et al. 2021

Rev. Bras. Frutic.

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The objective of this study was to characterize the chemical composition in extracts of atemoya (var. Thompson) seed oil by spectrometric methods. The following extraction methods were performed: chemical extraction using hexane, mechanical extraction using a press, and partitioned extraction. The composition of each of the extracts was analysed by gas chromatography-mass spectrometry (GC-MS), and more than 100 compounds were identified. The major constituents of the hexane extraction were (Z)-hexadec-9-enal (49.42%) and triolein (23.28%), and the mechanically obtained extract contained elaidic acid (66.11%) and stearic acid (8.81%). In the partitioned extraction, the hydromethanolic fraction contained dihydroxyacetone (19.16%), 3-deoxy-d-mannoic lactone (16.34%), 5-hydroxymethylfurfural (10.77%), and 3-propanediol, 2-(hydroxymethyl)-2-nitro (9.89%); the hexane fraction contained gamma-sitosterol (31.73%), erucic acid (14.64%), stigmasterol (13.30%) and triolein (10.90%); the chloroform fraction contained gamma-sitosterol (22.11%), vaccenic acid (15.49%), triolein (14.65%) and stigmasterol (10.65%); and the ethyl acetate fraction contained (Z)-icos-9-enoic acid (31.28%), beta-sitosterol (16.29%), pentadecanoic acid (11.53%) and eicosanoic acid (8.01%).

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Section: Resultsmentioning

confidence: 99%

Analysis of the chemical constituents of Thompson atemoya seed oil

Venceslau

Mendonça

Benedick³

et al. 2021

Rev. Bras. Frutic.

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“…With regard to other active substances present in E. arvense, dihydroxyacetone (Figure S2) has been reported to exhibit fungicidal activity in medical contexts [50], and 3-deoxy-d-mannoic lactone (present, for instance, in garlic) also has antimicrobial activity [51].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Assessment of Conjugate Complexes of Chitosan and Urtica dioica or Equisetum arvense Extracts for the Control of Grapevine Trunk Pathogens

et al. 2021

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In the work presented herein, we analyze the efficacy of three basic substances that comply with European Regulation (EC) No 1107/2009, namely chitosan, horsetail (Equisetum arvense L.) and nettle (Urtica dioica L.), for the control of grapevine trunk diseases (GTDs) in organic farming. The E. arvense and U. dioica aqueous extracts, prepared according to SANCO/12386/2013 and SANTE/11809/2016, have been studied by gas chromatography–mass spectrometry (GC-MS), identifying their main active constituents. The three basic substances, either alone or in combination (forming conjugate complexes), have been tested in vitro against eight Botryosphaeriaceae species, and in vivo, in grafted plants artificially inoculated with Neofusicoccum parvum and Diplodia seriata. A clear synergistic behavior between chitosan and the two plant extracts has been observed in the mycelial growth inhibition tests (resulting in EC90 values as low as 208 μg·mL−1 for some of the isolates), and statistically significant differences have been found in terms of vascular necroses lengths between treated and non-treated plants, providing further evidence of aforementioned synergism in the case of D. seriata. The reported data supports the possibility of extending the applications of these three basic substances in Viticulture beyond the treatment of mildew.

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“…Taken together, a solid body of scientific evidence provides a reasonable (bio)chemical basis to support the hypothesis that DHA may dehydratively glycate viral proteins and/or viral genomic RNA, which would in turn be expected to inactivate the virus, thus prophylactically protecting the wearer from facial transmission. Finally, independent support for DHA application is found in an isolated report that describes the antifungal activity of DHA to treat dermatomycosis [18] further highlighting potential biocidal activity.…”

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confidence: 94%

A hypothesis for examining dihydroxyacetone, the active component in sunless tanning products, as a topical prophylactic against SARS-COV-2 transmission

Perrin

2020

Medical Hypotheses

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This hypothesis raises the interesting prospect that dihydroxyacetone (DHA), the key ingredient in self-tanning creams, when applied daily to the face and hands may have prophylactic action against SARS-COV-2 transmission and infection. The scientific and mechanistic basis for this hypothesis is elaborated based on our understanding of the chemical reactivity of DHA with proteins to afford advanced glycation products. This piece ends with a proposal for doing key experiments that can be run to test this hypothesis. As more than 30 million people have been infected with this disease world-wide, a safe method for stopping spread is worthy of consideration. Publication of this hypothesis would enable the scientific community at large to test this in a clinically meaningful setting to address the potential for DHA-based prophylaxis. Given the calamity of this crisis, it is anticipated that the publication of this hypothesis, which is supported by key studies on protein and nucleoside glycation, can be disseminated to as many researchers as possible.

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In Vitro Antifungal Activity of Dihydroxyacetone Against Causative Agents of Dermatomycosis

Cited by 16 publications

References 19 publications

Analysis of the chemical constituents of Thompson atemoya seed oil

Analysis of the chemical constituents of Thompson atemoya seed oil

Assessment of Conjugate Complexes of Chitosan and Urtica dioica or Equisetum arvense Extracts for the Control of Grapevine Trunk Pathogens

A hypothesis for examining dihydroxyacetone, the active component in sunless tanning products, as a topical prophylactic against SARS-COV-2 transmission

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