2008
DOI: 10.1016/j.micres.2006.08.007
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In vitro antifungal susceptibility of clinical isolates of Candida spp. obtained from patients with different predisposing factors to candidosis

Abstract: The increase in the number of infections caused by Candida species and the consequent use of antifungal agents favours an increase of resistant isolates. The aim of this study was to evaluate the antifungal susceptibility of Candida spp. isolates from patients with different systemic predisposing factors to candidosis. Seventy-nine Candida spp. isolates were assayed for in vitro susceptibility to amphotericin B, fluconazole, 5-flucytosine and itraconazole using the technique proposed by the Clinical and Labora… Show more

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Cited by 21 publications
(16 citation statements)
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“…3 The widespread use of topical and systemic antifungal agents as conventional treatment for oral candidosis has resulted in the development of resistance in C. albicans. 4,5 Because the conventional antifungal agents exert a more fungistatic than fungicidal effect, prophylaxis is often inadequate. 6 Therefore, it becomes necessary to develop alternative therapies for the treatment of oral candidosis.…”
Section: Introductionmentioning
confidence: 99%
“…3 The widespread use of topical and systemic antifungal agents as conventional treatment for oral candidosis has resulted in the development of resistance in C. albicans. 4,5 Because the conventional antifungal agents exert a more fungistatic than fungicidal effect, prophylaxis is often inadequate. 6 Therefore, it becomes necessary to develop alternative therapies for the treatment of oral candidosis.…”
Section: Introductionmentioning
confidence: 99%
“…The yeast Candida albicans is a commensal organism frequently found in the oral cavity [1] that can cause opportunistic infections when some predisposing factors are present among the immunodeficiency, endocrine disorders, age extremes, radiotherapy, antibiotic therapies, transplants, malignant diseases and the use of orthodontic appliances [2][3][4][5]. The most common treatment is the use of antifungal agents, such as azoles (fluconazole, itraconazole, miconazole and ketoconazole) and polyenes (amphotericin B or nystatin).…”
Section: Introductionmentioning
confidence: 99%
“…As a matter of fact, a significant number of fungi species (especially Candida glabrata and Candida krusei) exhibited primary resistance to amphotericin B or was less susceptible to triazoles [4]. Furthermore, as a consequence of the toxicity of the currently used polyene antifungal drugs, which leads to interrupt the therapy, and the emergence of candidal species resistant to azole-based agents, there is an urgent need for developing alternative drug therapies [5].…”
Section: Introductionmentioning
confidence: 99%