In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham

Medeiros, Maria das Graças Freire de; Silva, Aline Caroline da; Citó, Antônia Maria das Graças Lopes; Borges, Andrezza Raposo; Lima, Sidney Gonçalo de; Lopes, José Arimateia Dantas; Figueiredo, Regina Célia Bressan Queiroz de

doi:10.1016/j.parint.2011.03.004

Cited by 122 publications

(78 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was about 250 times more toxic than thymol (LC50 480.20 μg/mL), which was used as a reference substance. In agreement with our data, a number of works indicates that thymol showed several biological activities, such as cytotoxicity (Buyukleyla & Rencuzogullari, 2009), antifungal, genotoxic (Stammati et al, 1999) and antileishmanial (De Medeiros et al, 2011) effects. Moreover, recent published data showed that thymol significantly increased the sister chromatid exchange, especially at the lower concentrations (75 and 100 µg/mL), induced both the chromosome aberration (CA) and frequency of micronucleus (MN), as well as dose-dependently decreased the nuclear division index (NDI) in human peripheral lymphocytes (Buyukleyla & Rencuzogullari, 2009).…”

Section: Resultssupporting

confidence: 93%

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Dutra¹,

Pittella²,

Dittz³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Pterodon emarginatus Vogel, Fabaceae, is a native aromatic tree distributed by central region of Brazil. Hydroalcoholic infusions of the seeds are used in folk medicine for their anti-rheumatic and anti-inflammatory properties. The objective of this work was identified the chemical components and verify the cytotoxic effect of the essential oil (EO) from P. emarginatus seeds. Thus, the EO of P. emarginatus seeds was analyzed by GC/MS analysis followed by brine shrimp lethality test and cytotoxic activity against tumor cell lines and human peripheral mononuclear blood cells (PBMC). The cancer cell lines tested were C 6 (rat glioma), MeWo (human melanoma), CT 26 .WT (mouse colon carcinoma), MDA (human breast cancer), A 549 (human lung carcinoma), B 16 -F 1 (mouse melanoma), CHO-K1 (hamster ovary cell) and BHK-21 (hamster kidney fibroblast). Eleven compounds were identified by GC and CG/MS analyses. The main compounds with concentrations higher than 5% were β-elemene (15.3%), trans-caryophyllene (35.9%), α-humulene (6.8%), germacrene-D (9.8%), bicyclo germacrene (5.5%) and spathulenol (5.9%). The EO of P. emarginatus seeds showed toxicity to Artemia salina (LC50 1.63 μg/mL) and was active against all the cell lines tested. The potent cytotoxic activity had IC50 values ranging from 24.9 to 47 μg/mL. However, EO (1-100 µg/mL) had less cytotoxicity in PBMCs isolated from a healthy subject. In summary, the present study showed the potential antiproliferative of the EO of P. emarginatus seeds.

show abstract

Section: Resultssupporting

confidence: 93%

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Dutra¹,

Pittella²,

Dittz³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…In T. cruzi, both eugenol (Santoro, Cardoso, Guimarães, Mendonça et al., 2007) and thymol (Santoro, Cardoso, Guimarães, Salgado et al., 2007) caused cytoplasmic swelling, rounding of the cell body, and altered nuclear morphology. In Leishmania major , both eugenol (Ueda‐Nakamura et al., 2006) and thymol (de Medeiros et al., 2011) affected mitochondria. In the yeast Candida albicans , both eugenol and thymol altered membrane morphology (Braga, Sasso, Culici, & Alfieri, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…In the yeast Candida albicans , both eugenol and thymol altered membrane morphology (Braga, Sasso, Culici, & Alfieri, 2007). Although neither compound affected the plasma membrane of T. cruzi (Santoro, Cardoso, Guimarães, Mendonça et al., 2007; Santoro, Cardoso, Guimarães, Salgado et al., 2007), eugenol altered the mitochondrial membrane in L. donovani (Ueda‐Nakamura et al., 2006), and thymol caused membrane wrinkling and submembrane accumulation of lipid droplets in L. amazonensis (de Medeiros et al., 2011). Given the similar chemical structures and modes of action of eugenol and thymol, we predicted that these compounds would behave additively.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of floral phytochemicals against a bumble bee parasite

Palmer‐Young¹,

Sadd

Irwin

et al. 2017

Ecology and Evolution

View full text Add to dashboard Cite

Floral landscapes comprise diverse phytochemical combinations. Individual phytochemicals in floral nectar and pollen can reduce infection in bees and directly inhibit trypanosome parasites. However, gut parasites of generalist pollinators, which consume nectar and pollen from many plant species, are exposed to phytochemical combinations. Interactions between phytochemicals could augment or decrease effects of single compounds on parasites. Using a matrix of 36 phytochemical treatment combinations, we assessed the combined effects of two floral phytochemicals, eugenol and thymol, against four strains of the bumblebee gut trypanosome Crithidia bombi. Eugenol and thymol had synergistic effects against C. bombi growth across seven independent experiments, showing that the phytochemical combination can disproportionately inhibit parasites. The strength of synergistic effects varied across strains and experiments. Thus, the antiparasitic effects of individual compounds will depend on both the presence of other phytochemicals and parasite strain identity. The presence of synergistic phytochemical combinations could augment the antiparasitic activity of individual compounds for pollinators in diverse floral landscapes.

show abstract

“…The effect of thymol, isolated from L. sidoides, has been demonstrated against the promastigote form of Leishmania amazonensis (Medeiros et al, 2011). Antiprotozoal activity also was observed against Trypanosoma cruzi (Santoro et al, 2007;Escobar et al, 2010a).…”

Section: Discussionmentioning

confidence: 97%

“…and Lippia sidoides Cham., popularly known as ''canelinha'' and ''alecrim-pimenta'', respectively. These species have shown antibacterial action and against promastigotes and amastigotes of Leishmania amazonensis (Costa et al, 2008;Medeiros et al, 2011). The volatile oils (VOs) of these plants also exhibit antimalarial activity against Plasmodium berghei in mice and Plasmodium falciparum in vitro (Mota et al, 2012).…”

mentioning

confidence: 99%

A Thiazole Derivative of Artemisinin Moderately ReducesToxoplasma gondiiCyst Burden in Infected Mice

Schultz

Hencken

Woodard

et al. 2014

Journal of Parasitology

View full text Add to dashboard Cite

In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham

Cited by 122 publications

References 23 publications

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Chemical composition and cytotoxicity activity of the essential oil of Pterodon emarginatus

Synergistic effects of floral phytochemicals against a bumble bee parasite

A Thiazole Derivative of Artemisinin Moderately ReducesToxoplasma gondiiCyst Burden in Infected Mice

Contact Info

Product

Resources

About