In vitro antimicrobial activity of light-activated phthalocyanines

Ryšková, Lenka; Buchta, Vladimı́r; Karásková, Marie; Rakušan, Jan; Černý, Jiřı́; Slezák, Radovan

doi:10.2478/s11535-013-0118-0

Cited by 16 publications

(16 citation statements)

References 25 publications

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“…The mixture was incubated in an oven equipped with a shaker for 30 min in the dark at 30 o C. Then half (2 mL) of the samples containing the Pc and cells was irradiated at the Qband maximum of the photosensitizers in quartz cell, using the set-up described above at different time intervals, while the other half was kept in the dark for dark toxicity studies. After irradiation, 100 µL samples were serially diluted and plated on agar plates [31,32]. Similar procedure was used for the conjugates.…”

Section: Antimicrobial Studiesmentioning

confidence: 99%

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Mthethwa

Nyokong

2015

Photochem Photobiol Sci

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The conjugates of aluminium phthalocyanine (complex 1) with gold nanorods (complex 1–AuNRs) and bipyramids (complex 1–AuBPs) showed improved singlet oxygen quantum yields of 0.23 and 0.24, respectively, compared to that of complex 1 alone at 0.12. Complex 1 and its conjugates were used for the photoinactivation of fungi (C. albicans) and bacteria cells (E. coli). The Q band absorbances were the same for the Pc alone and when conjugated to AuNPs. The efficiency of these conjugates was evaluated by measuring the log reduction of the microorganisms (C. albicans and E. coli) after irradiation with visible light in the presence of photosensitizers. Aluminium phthalocyanine alone showed log1.78 and log2.51 reductions for C. albicans and E. coli respectively. However, the conjugates showed higher photosensitization with log2.08 and log3.34 for C. albicans and E. coli, respectively using 1–AuBPs. For complex 1–AuNRs log2.53 and log3.71 were achieved for C. albicans and E. coli respectively. The statistical analysis of the results showed that the enhanced photoinactivation observed in both microorganisms was irrespective of the shape of the nanoparticles conjugated. Photoinactivation of C. albicans was less than that of E. coli even though a higher concentration of complex 1 or its conjugates was used in C. albicans.

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Section: Antimicrobial Studiesmentioning

confidence: 99%

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Mthethwa

Nyokong

2015

Photochem Photobiol Sci

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“…As already mentioned, the effectiveness of the antimicrobial action depends strongly on the kind of phthalocyanine derivatives and the type of microbial cells (Gram-positive bacteria, Gram-negative bacteria, or yeasts) [23]. An antimicrobial agent efficient against one type, or even strain, can be useless for the others.…”

Section: Discussionmentioning

confidence: 99%

Light-Activated Zirconium(IV) Phthalocyanine Derivatives Linked to Graphite Oxide Flakes and Discussion on Their Antibacterial Activity

et al. 2019

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In search of an effective antibacterial agent that is useful in photodynamic therapy, new derivatives of zirconium(IV) phthalocyanine (ZrPc) complexes were obtained and linked to graphite oxide flakes. In the syntheses of ZrPc derivatives, two bis-axially substituted ligands with terminal amino group and different lengths of linear carbon chain (C4 in 4-aminobutyric acid or C11 in 11-aminoundecanoic acid) were used. The optical properties (absorption and photoluminescence spectra) of ZrPcs and the composites were examined. Broadband red–near-infrared lamp was tested as an external stimulus to activate ZrPcs and the composites. Optical techniques were used to show generation of singlet oxygen during irradiation. Considering the application of graphite oxide-based materials as bacteriostatic photosensitive additives for endodontic treatment of periapical tissue inflammation, the antibacterial activity was determined on one Escherichia coli strain isolated directly from an infected root canal of a human tooth and one strain with silver and antibiotic resistance. Looking at the obtained results, modified levels of activity toward different bacterial strains are discussed.

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“…Vücutta gelişen herhangi bir enfeksiyonun tedavisinde kullanılan antibiyotik ve antiseptikler vücudun tümünü etkileyen maddelerdir. Foto dinamik antimikrobiyal terapinin, bu ilaçların yerine geçebilek; lokal olarak uygulanabilen, invasiv olmayan bir tedavi yöntemi olabileceği düşünülmektedir [28].…”

Section: Bazı Ftalosiyanin Yapılarının Antimikrobiyal öZelliklerinin unclassified

Chemical structures of phthalocyanine based dyestuffs and their useage in production of functional textiles

Özdemir¹,

Özgüney²

2017

Pamukkale J Eng Sci

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GirişTeknik tekstiller performansları ve fonksiyonel özellikleri için tercih edilmekte ve her geçen gün artan ürün çeşitliliği ile günlük yaşamımızda daha fazla yer almaktadırlar. Günümüzde kullanıcılarına örtünme, süsleme ve kendini ifade etmenin yanında; başta sağlık, güvenlik ve enformasyon alanlarında olmak üzere, başka hizmetler de sunabilen çok fonksiyonlu akıllı tekstil ürünlerinin üretimi sınırlı olarak yapılmaktadır.Bu çalışmada; ftalosiyanin bileşiklerinin kimyasal yapısı, sentez yöntemleri ve farklı endüstri dallarında birçok kullanım alanı sağlayan üstün özellikleri hakkında genel bilgi verilmiştir. Bu üstün özelliklerin, çeşitli fonksiyonel özelliklere sahip teknik tekstillerin üretiminde kullanılabileceği anlatılmaya çalışılmıştır. Bu fikri desteklemek için; tekstil materyallerinin renklendirilmesinde kullanılan bazı farklı ftalosiyanin yapıları ve özellikleri hakkında detaylı bilgi verilerek, bu konuda son yıllarda yapılmış bazı çalışmalara yer verilmiştir: Klasik sübstitüentsiz bakır ftalosiyanin dışında, sentezlenen yeni farklı metalloftalosiyanin türevlerinin yapısı, tekstil materyallerinin renklendirilmesinde kullanılabilirliği, boyama ve haslık özelliklerinin incelenmesi ve materyalin bitim işlemsiz sadece renklendirme prosesi sonucu kazandığı antibakteriyel fonksiyonel özelliğinin nedenleri üzerinde durulmuştur. Ligand ve metal iyonu arasındaki uyumun derecesini, koordinasyon oyuğunun boyutları belirler [3]. Bugüne kadar 70'ten fazla farklı element kullanılarak metalli ftalosiyanin sentezlenmiştir. Neredeyse her metal ve bor, silisyum, germanyum ve arsenik gibi bazı yarı metaller ve metal olmayan fosfor, bir ftalosiyanin ligandı ile koordine olabilir [4]. Ftalosiyaninlerin kimyasal yapısı ve sentez yöntemleri

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In vitro antimicrobial activity of light-activated phthalocyanines

Cited by 16 publications

References 25 publications

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Light-Activated Zirconium(IV) Phthalocyanine Derivatives Linked to Graphite Oxide Flakes and Discussion on Their Antibacterial Activity

Chemical structures of phthalocyanine based dyestuffs and their useage in production of functional textiles

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